[PDF] Top 20 B7 dependent T cell costimulation in mice lacking CD28 and CTLA4
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B7 dependent T cell costimulation in mice lacking CD28 and CTLA4
... growing B7 and CD28 families of costimu- latory molecules ...to CD28, was shown to bind the B7h molecule (also called B7RP-1), which is homologous to B7-1 and B7-2 (23), and stimulate ... See full document
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Chronic cardiac rejection in the LEW to F344 rat model Blockade of CD28 B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis
... mononuclear cell infiltra- tion, and significantly reduced gene transcript and product lev- els for key T cell and macrophage activation markers in the LEW to F344 rat model of chronic ...both ... See full document
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Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses
... a CTLA4-dependent immunomodulation through an increase in Treg infiltration into the graft ...control-treated mice, the principal effect of FR104 is likely to be the suppression of effector T ... See full document
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A viral protein that selectively downregulates ICAM 1 and B7 2 and modulates T cell costimulation
... strong T cell ...or lacking K5 genes) to stimulate Jurkat T cells in the presence of ...by T cell-APC engagement, including NFAT and ...to CTLA4-Ig, NFAT and AP-1 ... See full document
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CD28 costimulation independence of target organ versus circulating memory antigen specific CD4+ T cells
... (MBP-reactive) T cells in the blood were found to be less dependent on CD28 costimulation for T cell proliferation as compared with MBP-specific T cells from healthy ... See full document
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CD28/B7 Mediated Co stimulation Is Critical for Early Control of Murine Cytomegalovirus Infection
... Much like APC = T-cell interactions, APC = NK interactions have also been shown to be critical in development of NK- cell responses to MCMV. Early during MCMV infection, APCs produce IFN- a=b and ... See full document
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B7 Costimulation Molecules Expressed from the Herpes Simplex Virus 2 Genome Rescue Immune Induction in B7-Deficient Mice
... between B7 costimulation molecules on antigen-presenting cells and CD28 on antigen- responsive T cells is essential for T-cell activation and maturation of immune responses to ... See full document
11
B7-Mediated Costimulation of CD4 T Cells Constrains Cytomegalovirus Persistence
... CD4 T cell responses and viral load in ...CD8 T cell pool after primary infection (12, 33, 36), al- though NK control and CD8 T cell restriction of replication in the salivary ... See full document
7
Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1
... in mice with antibody blocked CD28 and CTLA4 (CD152)-B7 (CD80/86) interactions (Gause et ...1996). CD28 knockout mice resist challenge e ff ectively, as do also CD80/86 knockouts ... See full document
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Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model
... blocking CD28 sig- naling with CTLA4-Ig has been shown to produce prolonged T cell unresponsiveness termed anergy ...linking T cell activation through CD28 ... See full document
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Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL 4 dependent mechanism
... NOD mice provides the costimulation re- quired for the expansion of and cytokine production by regula- tory IL-4–producing Th2-like ...splenic T cells obtained at 8 wk and 25 wk, and islet- ... See full document
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Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice
... murine B7-1 or B7-2 to determine whether expression of B7 costimulation molecules could aug- ment vaccine-induced immune responses to HSV-2 itself ...B7KO mice, immunization with ... See full document
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Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation
... T-cell costimulation molecules B7-1 and B7-2 play an important role in activation of T cells to cytolytic effector function and production of ...with B7 also causes ... See full document
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A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions
... monoclonal T-cell-specific ...to T-cell activation and response ...their B7- ligands in the context of a potentially dynamic synaptic microenvironment ... See full document
17
CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
... besides CD28 costimulation will be required by T cells to allow them to pass through the physiological sequence of activation, proliferation, and survival check points to which T cells are ... See full document
6
Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic HIV-1 Infection
... non-HIV-specific T cells dur- ing chronic HIV infection, we would like to introduce sev- eral possible sources of antigenic stimulation which have been discussed previously in the context of HIV-1 pathogenesis (4, ... See full document
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Contribution of CD4+, CD8+CD28+, and CD8+CD28 T cells to CD3+ lymphocyte homeostasis during the natural course of HIV 1 infection
... mature T lymphocytes, which express the CD4 and the CD8 cell surface markers, re- spectively, can be divided further according to biological prop- erties, expression of surface markers, and ability to ... See full document
9
A short CD3/CD28 costimulation combined with IL 21 enhance the generation of human memory stem T cells for adoptive immunotherapy
... of T cell [32]. Similarly, T cells expanded in the presence of IL-21 (the unique common γ-chain cytokines to sustain STAT3 activation) prevent the loss of CD45RA, CD62L, CD27, and IL-7Rα, increasing ... See full document
10
Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation
... ⫹ T cells were treated for 24 h with disul- firam, DDTC, or anti-CD3 plus anti-CD28 antibodies or were left ...⫹ T cells treated with medium alone, disulfiram, or DDTC or costimu- lated for 48 h was ... See full document
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Prognostic value of programmed cell death-ligand 1 expression in patients with non-small-cell lung cancer: evidence from an updated meta-analysis
... Regardless of these limitations, the results of the pres- ent study suggest that, in clinical trials, when anti-PD-L1 antibodies are used for cancer immunotherapy, patients with NSCLC should be carefully selected. ... See full document
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