[PDF] Top 20 Basic Residues in Hypervariable Region 1 of Hepatitis C Virus Envelope Glycoprotein E2 Contribute to Virus Entry
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Basic Residues in Hypervariable Region 1 of Hepatitis C Virus Envelope Glycoprotein E2 Contribute to Virus Entry
... HCV envelope glycoprotein E2 and heparin, it has been postulated that highly sulfated heparan sulfate may serve as the initial docking site for HCV attachment ...of E2 and heparin, E2 ... See full document
11
Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies
... HCV entry is currently ...HCV envelope with cell membranes ...truncated E2 (sE2) via HVR1 (53). However, sE2 may not fully mimic E2 structures on the HCV virion (11, 28) and an interaction ... See full document
14
Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization
... adaptive envelope mutations is made difficult by the absence of an X-ray or nuclear magnetic resonance structure of the E1/E2 het- ...or E2 shown to be im- portant for E1/E2 heterodimerization ... See full document
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An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry
... The hepatitis C virus (HCV) envelope glycoprotein E2 is the major target of broadly neutralizing antibodies in vivo and is the focus of efforts in the rational design of a ... See full document
18
Disulfide Bonds in Hepatitis C Virus Glycoprotein E1 Control the Assembly and Entry Functions of E2 Glycoprotein
... viral envelope glycoproteins change at different steps of the viral life cycle, disulfide bonds within these proteins are particularly important to keep them ...cysteine residues strongly impairs the ... See full document
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Mutations of Glu560 within HIV 1 Envelope Glycoprotein N terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
... and C‑terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV‑1 infection in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 to form a six‑helix ... See full document
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Binding of the Hepatitis C Virus E2 Glycoprotein to CD81 Is Strain Specific and Is Modulated by a Complex Interplay between Hypervariable Regions 1 and 2
... N-glycosylated envelope glyco- proteins, E1 (⬃31 kDa) and E2 (⬃70 ...and E2 are believed to be type 1 transmembrane proteins, with N- terminal ectodomains and C-terminal hydrophobic ... See full document
12
Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly
... N-terminal region of the E1 ectodomain corresponds to the disordered loop between  4 and  5 that was not seen in the electron density of the crystallographic ...mutated residues in the context of an ... See full document
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Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region
... binding residues and is adjacent to the front layer, where ad- ditional surface-exposed CD81 contact residues are found ...This region of E2 was termed the neutralizing face, as many of the ... See full document
17
Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (gp70) hypervariable region 1 in viremic hepatitis C virus-infected patients.
... ciency virus (9, ...influenza virus, infection and in togavirus, paramyxovirus, and enterovirus (5), has recently been suggested to be active also for human im- munodeficiency virus infection ...the ... See full document
6
Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus
... Hypervariable region 1 (HVR1) (amino acids [aa] 384 to 410) on the E2 glycoprotein of hepatitis C virus contributes to persistent infection by evolving escape ... See full document
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Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine
... the virus is capable of escaping neutralization through the selection of mutants within its quasispecies ...including hypervariable region 1 (HVR1), HVR2, and HVR3 (the latter is also known as ... See full document
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Transmembrane Domains of Hepatitis C Virus Envelope Glycoproteins: Residues Involved in E1E2 Heterodimerization and Involvement of These Domains in Virus Entry
... the residues located immediately downstream of positions 354, 358, and 370 (V355, I359, and V371, respectively) also had some effect on E1E2 heterodimerization, suggesting that they might also par- ticipate in the ... See full document
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Characterization of Hepatitis C Virus Recombinants with Chimeric E1/E2 Envelope Proteins and Identification of Single Amino Acids in the E2 Stem Region Important for Entry
... and E2 is a requirement to obtain infectious HCVpp (26, 52, ...without E2 stem region ...the E2 glycoprotein, including the importance of the stem region for HCV entry ... See full document
15
A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1
... JFH-1 E2 is important for the interaction with SR-B1, either directly or through interactions medi- ated by lipoproteins, while this interaction is more strongly mediated by HVR1 for the J6 ...J6 ... See full document
15
Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope Glycoprotein
... HCV envelope glycoproteins can partially protect against homologous challenge (29, ...of E2 to CD81 have been described (1, 9, 33, 34, 36, ...immunodeficiency virus type 1 have shown ... See full document
10
Identification and Characterization of Broadly Neutralizing Human Monoclonal Antibodies Directed against the E2 Envelope Glycoprotein of Hepatitis C Virus
... and E2. Additionally, any changes found in the NIH HCV database for E2 amino acids 413, 418, and 420, critical residues according to alanine scan- ning mutagenesis, were also engineered into the ... See full document
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Identification of Conserved Residues in Hepatitis C Virus Envelope Glycoprotein E2 That Modulate Virus Dependence on CD81 and SRB1 Entry Factors
... of E2 protein ...on virus assembly also suggests that these res- idues are not involved in interactions with HCV glycoprotein E1, and the lack of effect on virus entry and interaction ... See full document
14
Role of Hypervariable Region 1 for the Interplay of Hepatitis C Virus with Entry Factors and Lipoproteins
... Hepatitis C virus (HCV) particles associate with lipoproteins and infect cells by using at least four cell entry ...claudin 1 (CLDN1), and occludin ...cell entry and viral ... See full document
12
Conservation of the Conformation and Positive Charges of Hepatitis C Virus E2 Envelope Glycoprotein Hypervariable Region 1 Points to a Role in Cell Attachment
... (1 month after the end of the first IFN-␣ course), M9 (beginning of the second IFN-␣ course), M15 (end of the second IFN-␣ course), and M21 (6 months after the end of the second IFN-␣ course). The fre- quency of ... See full document
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