[PDF] Top 20 Bench to bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
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Bench to bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
... (12.0 ± 1.6 versus 7.1 ± 1.2; P = 0.026). An increase in circu- lating ECs can therefore be identified during sepsis and septic shock. That study was among the first to support the hypothesis that ... See full document
9
Clinical manifestations of disordered microcirculatory perfusion in severe sepsis
... Microcirculatory dysfunction plays a pivotal role in the development of the clinical manifestations of severe ...This review explores: (1) the clinical manifestations of severe ... See full document
7
Bench to bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis
... cardiovascular dysfunction and septic shock. Sepsis is especially devastating in the neonatal population, as it is one of the leading causes of death for hospitalized ...to severe organ ... See full document
9
Bench to bedside: A role for erythropoietin in sepsis
... of sepsis and infl ...of sepsis-induced acute lung injury, including circulating proinfl ammatory cytokines, polymorphonuclear cell accu mulation and lipid peroxidation, with better mainte- nance of ... See full document
8
Bench to bedside review: Targeting antioxidants to mitochondria in sepsis
... prevented cell death induced by hydrophobic bile acids, via eff ects on nitric oxide synthesis, in an in vitro study of hepatocytes ...heart dysfunction, cell death, and mitochondrial damage upon ... See full document
9
Bench to bedside review: Understanding genetic predisposition to sepsis
... of sepsis, the response to current medical treatment, and the genetic predisposition to infection in each individual ...of sepsis and organ dysfunction during severe ...this ... See full document
10
Bench to bedside review: Sepsis, severe sepsis and septic shock – does the nature of the infecting organism matter?
... the cell walls of Gram-negative and Gram-positive bacteria, ...Indeed, cell wall extracts from Gram-positive and Gram-negative organisms contain components that can activate both receptors ... See full document
6
Bench to bedside review: β Adrenergic modulation in sepsis
... of sepsis and contributes to the development of organ dysfunction and shock ...following severe infection, however, remain poorly ...of organ function and cardiovascular ... See full document
8
Bench to bedside review: Microvascular dysfunction in sepsis –hemodynamics, oxygen transport, and nitric oxide
... in endothelial cells by the constitutively expressed NOS enzyme in response to receptor mediated and shear stress vasodilatory stimuli ...from endothelial cell to smooth muscle cell, where it ... See full document
15
Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction
... major endothelial cell surface proteoglycans are syndecans, which are heparan sulfate ...the endothelial surface layer, and circulating syndecan-1 is a marker of endothelial glyco- calyx ... See full document
9
Organ dysfunction as a new standard for defining sepsis
... Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increases concurrent with the aging ...of sepsis was originally based on the ... See full document
6
A Nonerythropoietic Peptide that Mimics the 3D Structure of Erythropoietin Reduces Organ Injury/Dysfunction and Inflammation in Experimental Hemorrhagic Shock
... At the end of the experiment, lung samples were excised and fixed in 10% (w/v) formalin, buffered with phosphate buffered saline (PBS, 0.01 M, pH 7.4) for 1 wk. Samples then were dehydrated using graded ethanol, embedded ... See full document
10
Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients
... the cell cytoskeleton during migration of phagocytes [17-19] The extracellular effects include pro- inflammatory, antimicrobial, oxidant scavenging and apoptosis-inducing ...neutrophil cell death, along ... See full document
7
Year in review 2010: Critical Care multiple organ dysfunction and sepsis
... acquired sepsis to 17 ICUs that represented 41% of all Portuguese ICU ...for sepsis severity, Simplifi ed Acute Physiology Score II (SAPS II), and number of comorbidities – the two actions signifi cantly ... See full document
6
Levosimendan for the prevention of acute organ dysfunction in sepsis
... This trial has several limitations. We inves- tigated levosimendan as added to standard care rather than a comparison of levosimendan with an alternative inotrope, such as dobutamine. Less than 10% of the patients in the ... See full document
12
Endocan (endothelial cell specific molecule 1) as a pertinent biomarker of endothelial dysfunction in sepsis
... Phage display technology is a technique to express a protein fused to a coat protein of a fi lamentous phage. The most widely used coat protein is pIII encoded in the phage genome by gIII. This gene contains a signal ... See full document
23
Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis
... of sepsis (12) and a small single-center study using older criteria for sepsis and septic shock ...the Sepsis-3 definition, which highlights organ dysfunction rather than the systemic ... See full document
10
Bench to bedside review: Association of genetic variation with sepsis
... An alternative to genotyping tag SNPs across the genome, as in GWAS, is to directly test association of large numbers of nonsynonymous SNPs (nsSNPs), or amino acid changing SNPs, to disease. There are now almost 60,000 ... See full document
10
Clinical utility of biomarkers of endothelial activation in sepsis a systematic review
... and sepsis or clinical outcomes was limited by a lack of standardization in individual bio- marker assays, an absence of identified or validated thresh- olds or cut-points in individual biomarker levels, and a ... See full document
20
An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan dysfunction in Sepsis (LeoPARDS ) : protocol for a randomized controlled trial
... dialysis-dependent); severe chronic hepatic impairment (Child-Pugh class C); a history of Torsades de Pointes; known significant mechanical ob- structions affecting ventricular filling or outflow or both; ... See full document
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