[PDF] Top 20 Role of the TRAF Binding Site and NF-κB Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression
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Role of the TRAF Binding Site and NF-κB Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression
... cellular gene expression by the Epstein-Barr Virus (EBV) latent membrane protein 1 ...the expression of ICAM-1, LFA-3, CD40, and EBI3 in ... See full document
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Latent Membrane Protein 1 Regulates STAT1 through NF-κB-Dependent Interferon Secretion in Epstein-Barr Virus-Immortalized B Cells
... Constitutive activation of signal transducer and activator of transcription 1 (STAT1) is a distinctive feature of Epstein-Barr virus (EBV)-immortalized B cells (lymphoblastoid ... See full document
8
Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene.
... of membrane receptors lacks intrinsic kinase activity but may transmit signals through interactions with various mem- bers of the TRAF family (62, 63, ...the membrane of infected cells similar to ... See full document
7
The Oncogenic Protein Kinase Tpl-2/Cot Contributes to Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1-Induced NF-κB Signaling Downstream of TRAF2
... LMP1 expression in fibroblasts and cell lines of epithelial and B-cell origins promotes filopodia formation (14, 56, 57) via a Cdc42-dependent pathway ...and cell po- larity. Previous work ... See full document
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Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-κB Signaling Pathways
... and NF- B activation, which modulates Glut-1 ...family protein kinase for regulating cell growth and proliferation via distinct pathways, including regulation of protein ... See full document
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Silencing of the Epstein-Barr Virus Latent Membrane Protein 1 Gene by the Max-Mad1-mSin3A Modulator of Chromatin Structure
... LMP1 gene regulatory sequence (LRS) is composed of both positive and negative transcriptional cis elements, and the gene is inactive in the absence of the ...cellular protein kinase A (20) and ... See full document
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Induction of Epidermal Growth Factor Receptor Expression by Epstein-Barr Virus Latent Membrane Protein 1 C-Terminal-Activating Region 1 Is Mediated by NF-κB p50 Homodimer/Bcl-3 Complexes
... The Epstein-Barr virus (EBV) is associated with the development of numerous malignancies, including the epithelial malignancy nasopharyngeal carcinoma ...oncoprotein latent membrane ... See full document
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Matrix Metalloproteinase 9 Expression Is Induced by Epstein-Barr Virus Latent Membrane Protein 1 C-Terminal Activation Regions 1 and 2
... of gene transcription, (ii) activation of the latent form of the enzyme to its active form by eliminating an N-terminal peptide, and (iii) regulation by endogenous proteins known as tissue inhibitors ... See full document
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Epstein-Barr Virus Nuclear Antigen 3C Activates the Latent Membrane Protein 1 Promoter in the Presence of Epstein-Barr Virus Nuclear Antigen 2 through Sequences Encompassing an Spi-1/Spi-B Binding Site
... well-defined role as a repressor of EBNA-2-mediated activation of transcription (via interac- tion with J), can also activate gene ...in gene fusion assays ...activate gene ... See full document
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Activation of sterol regulatory element binding protein 1 (SREBP1) mediated lipogenesis by the Epstein Barr virus encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma
... of expression of FASN and LMP1 (Figure 4A), a high level of FASN expression in NPC primary tumors was common, and correlated significantly with LMP1 expression (Figure ...FASN expression was ... See full document
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Epstein-Barr Virus Latent Membrane Protein 1 Modulates Distinctive NF-κB Pathways through C-Terminus-Activating Region 1 To Regulate Epidermal Growth Factor Receptor Expression
... vates NF- B transcriptional ...distinct NF- B-activating domains in the carboxy termi- nus, CTAR1 and CTAR2, and determined that CTAR2 had greater activity in NF- B reporter assays (18, ...of ... See full document
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The Epstein-Barr virus latent membrane protein 1 regulates gene expression by engaging multiple signaling pathways
... EGFR expression (36). Expression of CTAR1 in MEF cells defective for different TRAFs revealed that TRAF2 and TRAF3, but not TRAF6, are required for CTAR1-mediated EGFR induction (Figure ...CTAR1 ... See full document
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Canonical NF-κB Activation Is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation
... Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) transforms rodent fibroblasts and is ex- pressed in most EBV-associated ...effector site 2 ... See full document
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Analysis of Epstein-Barr Virus-Regulated Host Gene Expression Changes through Primary B-Cell Outgrowth Reveals Delayed Kinetics of Latent Membrane Protein 1-Mediated NF-κB Activation
... lated gene expression changes identified the induction of E2F fam- ily members and the phosphorylation of pocket proteins enabling E2F-mediated transcription and S-phase induction within the first few days ... See full document
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TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40
... in cell lines lacking detectable TRAF1 indicates that TRAF1 is not critical for these ...exogenous expression of TRAF1 or TRAF1⌬ does not influence CD40 and LMP1 CTAR2-mediated JNK signal- ...the ... See full document
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Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus.
... in 1 3 sodium dodecyl sulfate (SDS) sample buffer ...recombinant, protein fusion of b -galactosidase and the last 199 amino-acid residues of LMP, as described previously ...a 1:1,000 dilution of ... See full document
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Epstein-Barr Virus Latent Membrane Protein 2A Contributes to Anoikis Resistance through ERK Activation
...  1-integrin and epidermal growth factor receptor (EGFR) coor- dinately regulates Bim expression for the prevention of anoikis in epithelial cells via ERK activation ...causes cell detachment, ... See full document
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Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation
... and latent EBV infection (2, ...a latent reservoir and continual propa- gation of cells that efficiently retain segregated episomal EBV genomes are likely preneoplastic conditional events preceding the ... See full document
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Overexpression of Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) in oral squamous cell carcinoma
... 10 min in 10 mM citrate buffer pH 6.0. They were then washed in phosphate buffered saline (PBS), covered by 5% bovine serum albumin (Sigma-Aldrich) for 30 min. Sections were treated with primary antibody for 2 h in a ... See full document
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Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1
... important role in Tap-2 promoter activity, because results from reporter assays were in agreement with the levels of endogenous Tap-2 RNA (see ...IRF-7 expression plasmids and IRF-7 antibody have been ... See full document
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