[PDF] Top 20 Role of the ATP-Binding Domain of the Human Papillomavirus Type 11 E1 Helicase in E2-Dependent Binding to the Origin
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Role of the ATP-Binding Domain of the Human Papillomavirus Type 11 E1 Helicase in E2-Dependent Binding to the Origin
... of E1 to E2 was also affected by substitutions that changed lysine 484 of the E1 P ...to E2 binding, with the exception of arginine, which most closely resembles ...affect E2 ... See full document
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Association of the Human Papillomavirus Type 11 E1 Protein with Histone H1
... The E1 and E2 proteins are the only virus-encoded factors required for human papillomavirus (HPV) DNA ...The E1 protein is a DNA helicase responsible for initiation of DNA ... See full document
8
A C-Terminal Helicase Domain of the Human Papillomavirus E1 Protein Binds E2 and the DNA Polymerase α-Primase p68 Subunit
... highly dependent on the host cell for repli- cation and expression of their ...vine papillomavirus type 1 (BPV-1), whose DNA can be prop- agated in cell lines as an episome, showed that the viral ... See full document
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Cellular Topoisomerase I Modulates Origin Binding by Bovine Papillomavirus Type 1 E1
... that E1 recruits Topo I to the PV replication fork through the interaction between the E1 C terminus and Topo I ...the role of Topo I in PV DNA repli- cation ...replication, E2 and Topo I can ... See full document
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Characterization of the Minimal DNA Binding Domain of the Human Papillomavirus E1 Helicase: Fluorescence Anisotropy Studies and Characterization of a Dimerization-Defective Mutant Protein
... the E1 DBD of HPV11, HPV18 and BPV using a novel quantitative DNA-binding as- say based on fluorescence ...sequence-specific binding. This and other experiments suggested that only binding ... See full document
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Isolation of an amino-terminal region of bovine papillomavirus type 1 E1 protein that retains origin binding and E2 interaction capacity.
... bovine papillomavirus type 1 (BPV-1) E1 protein is an essential viral DNA replication factor that is both an origin recognition protein (5, 6, 13, 17, 18, 20) and an ATP-depen- dent ... See full document
5
Requirement for the E1 Helicase C-Terminal Domain in Papillomavirus DNA Replication In Vivo
... second E1 protein, that of HPV11. Second, it evaluates the function of the E1 CTD in vivo in a cell-based viral DNA replication ...the E1 CTD to helix 9 to assess its role in DNA replication ... See full document
14
Human TATA Binding Protein Inhibits Human Papillomavirus Type 11 DNA Replication by Antagonizing E1-E2 Protein Complex Formation on the Viral Origin of Replication
... that E2’s inhibition of TBP binding is independent of cofactors and transcriptional corepressors ...that E2 inhibits multiple steps of the transcriptional preinitiation assembly complex and that ... See full document
10
Identification of Domains of the Human Papillomavirus Type 11 E1 Helicase Involved in Oligomerization and Binding to the Viral Origin
... DNA binding could be stimulated to bind to the origin by E2 ...of E2 on the binding of the various region A mutant E1 proteins to the HPV ...649) E1 mu- tant proteins as ... See full document
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Inhibition of Human Papillomavirus DNA Replication by an E1-Derived p80/UAF1-Binding Peptide
... the E1-p80 interaction is not strictly essential for tran- sient DNA replication, it greatly enhances the overall efficiency of the ...in E1 that abrogate p80 binding or overexpression of the N40 ... See full document
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Differential Requirements for Conserved E2 Binding Sites in the Life Cycle of Oncogenic Human Papillomavirus Type 31
... -18 origin con- structs to the same extent as mutation of BS3 (8, ...of E1 and E2 was from the intact HPV31 ...of origin plasmids (8, 23, ...of E2-mediated P97 repression resulting in ... See full document
7
Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements.
... These results clearly demonstrate that interference with the function of the putative Spl site by the E2 proteins bound to E2-RS 3 is responsible for the E6 promoter repression mediated [r] ... See full document
13
Identification and Analysis of Papillomavirus E2 Protein Binding Sites in the Human Genome
... represent binding sites in vivo. In our study, E2 was able to bind to only one of the high-affinity E2BSs with A/T-rich spacers in vivo and to at least one of the two E2BSs within the HMGB2 intron that have ... See full document
10
Two Patches of Amino Acids on the E2 DNA Binding Domain Define the Surface for Interaction with E1
... between E1 and ...the E2 DBD and E1 are not contiguous residues in the protein se- quence but map to two distinct ...the E2 DBD. Both patches are on a surface that would face E1 bound ... See full document
7
Evolutionary variation of papillomavirus E2 protein and E2 binding sites
... PV E2 proteins have evolved different affinities and different preferences for E2BSs, including spacer nucleotides, which control E2BS ...the E2 protein function has been performed on domains from a ... See full document
12
Werner Helicase Control of Human Papillomavirus 16 E1 E2 DNA Replication Is Regulated by SIRT1 Deacetylation
... and E1 during E1-E2-mediated DNA ...alter E1-E2 DNA replication properties, although removal of SIRT1 does boost this replication ...the E2 protein that enhances replication ... See full document
21
Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins.
... Cotransfection of the full-length El expression vector together with either the ElM^E2C or the CM4 vector failed to support transient replication of p7072-99 in CHO, 293, or C-33A cells [r] ... See full document
8
Human herpesvirus 6B origin-binding protein: DNA-binding domain and consensus binding sequence.
... the human herpesvirus 6B (HHV-6B) replication origin has a structure similar to those of alphaherpesviruses, although the HHV-6B and herpes simplex virus type 1 (HSV-1) origin-binding ... See full document
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Low-affinity E2-binding site mediates downmodulation of E2 transactivation of the human papillomavirus type 8 late promoter.
... 6959-6966 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology Low-Affinity E2-Binding Site Mediates Downmodulation of E2 Transactivation of the Human Papillomavirus[r] ... See full document
8
The Interaction between Human Papillomavirus Type 16 and FADD Is Mediated by a Novel E6 Binding Domain
... FIG. 4. Two combinations of three amino acid mutations in FADD DED inhibit E6-mediated FADD degradation, while leaving other tested biological functions of FADD intact. (A) E6 cannot bind to SLT3 or SLT4 and thus does ... See full document
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