[PDF] Top 20 Biophysical regulation of stem cell behavior within the niche

... spatial regulation of cues at the nano- scale, microscale features in the niche can play key ...NSC niche, raising the hypothesis that cells may respond to ECM surface ... See full document

... the regulation and function of stem cell-niche adhesion remain to be ...given stem cell type to interact with its ...purifying stem cells and for identifying surface ... See full document

... governing stem cell behavior is now commonly accepted, with cells contributing to the niche of tissues, like blood, gut, skin, and brain, increasingly being ...between stem cell ... See full document

... efficiently deletes spry1 and increases a downstream transcriptional target of FGF signalling, erm in vivo (Supplementary Fig. 7). After a short-term deletion of spry1, the number of Pax7 + cells (Fig. 4b) and percentage ... See full document

... self-renewing stem cell and proceeding through transit-amplifying cell stages before transitioning into the terminal differentiated state – was uncovered in the embryonic and hematopoietic ... See full document

... common stem cell marker in diverse ...of stem cells within the niche, maintenance of stem cell stemness, regulation of stem cell differentiation, ... See full document

... progenitor cell pools are controlled and maintained in developing and adult ...nutrient-based regulation of stem and progenitor cell fate and how nutrient availability relates to metabolic ... See full document

... monoclonal antibody against glial fibrillary acidic protein (mGFAP, arrow, D), and thus are astrocytic. FoxJ1 protein expression in a subset of astrocytes was confirmed with the FoxJ1-mAb simultaneously stained with a ... See full document

... c cell surface markers allowed the isolation, purifi cation, and func tional characterization of HSCs in vitro and in vivo, leading to the recent identifi cation of a population of highly quiescent, ... See full document

... testis stem cell niche, we used a Cre recombinase-loxP conditional knockout strategy to disrupt Rbpj function in Sertoli cells before ...germ cell numbers – although accompanied by an ... See full document

... the regulation of SSC survival and self-renewal (Kubota et ...the regulation of testosterone production, and in spermatogenesis (Froment et ...Leydig cell-derived IGF-I mediates the maintenance of ... See full document

... extrinsic regulation by the surrounding HSC niche (Nakamura-Ishizu and Suda, ...by niche cells, such as the inflammatory cytokine CC- chemokine ligand 5 (CCL5), might contribute to the age-associated ... See full document

... asymmetric cell division provides a mechanism for the crucial regulation of stem cell numbers, and Weimin Zhong (Yale University, New Haven, CT, USA) asked whether stem cells use ... See full document

... designing stem cell culture environments in micro-bioreactor formats) ...of cell and culture materials ...on cell survival, growth, and dif- ferentiated phenotype ...and biophysical ... See full document

... Tissue-specific stem cells and their niches are organized into functional units that respond to external cues in order to maintain organ ...of niche-stem cell units during organogenesis has ... See full document

... The niche plays a vital role in maintaining stem cell function throughout the lifespan of an ...the niche concept at the structural and molecular level, with Dpp being the primary ... See full document

... mesenchymal stem cell line derived from C3H mice were ...this cell line has been shown to be responsive to fluid flow stimuli (Arnsdorf et ...mesenchymal stem cells, it has also been shown to ... See full document

... Stem cell proliferation and maintenance are typically regulated by niches: signalling microenvironments within tissues that allow resident stem cells to fulfil their functions (Scadden, ... See full document

... non-cell-autonomous regulation of stem cells by nutrients and hormones has also been found in the stem cell niche of the fly central nervous system (Sousa-Nunes et ...in ... See full document

... the cell body and either expressed the neuronal marker MAP2 or co-expressed MAP2 and an additional neuronal marker, double- ...from stem/progenitor cells that express GFAP by only counting cells that were ... See full document