[PDF] Top 20 Bone loss: Factors that regulate osteoclast differentiation an update
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Bone loss: Factors that regulate osteoclast differentiation an update
... osteotropic factors and hormones such as PTH, 1,25(OH) 2 D 3 , IL-11, IL-1 β , TNF- α or prostaglandin E 2 upregulate RANKL expression in osteoblast/stromal cells ...hormonal factors that are involved in ... See full document
6
MMP 13 stimulates osteoclast differentiation and activation in tumour breast bone metastases
... dissolving bone matrix, an osteolytic activ- ity complementing MMP-9 and other enzymes ...of factors, including hormones and cytokines, pre- sent in the bone microenvironment, such as PTH and PTHrP ... See full document
15
Hypoxic regulation of osteoclast differentiation and bone resorption activity
... Abstract: Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce ...of osteoclast ... See full document
10
RIP140 in monocytes/macrophages regulates osteoclast differentiation and bone homeostasis
... induce osteoclast differentiation ...can regulate gene expression by interacting with tran- scription regulators, we explored whether RIP140 could also act as a transcription coregulator of upstream ... See full document
14
Role of key players in paradigm shifts of prostate cancer bone metastasis
... of bone remod- eling through ...conditions, bone remodeling process consists of a series of highly coordinated and closely regulated ...preosteoclasts’ differentiation, migration, and fusion to form ... See full document
8
Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss
... postmenopausal bone loss, acti- vated T cells and APCs were shown to regulate the bone re- sorption process ...soluble factors secreted from the activated ...altered bone ... See full document
7
The Effects of Adiponectin on Bone Metabolism
... new bone from osteoblasts ...of bone remodeling, Oc adhere to bone to remove the exterior rigid structure by acidification and proteolytic ...new bone formation along with the secretion of ... See full document
11
Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation
... silent bone disease that can result in low-energy impact fractures with significant morbidity and associated mortality rates ...offset bone loss through medications that inhibit catabolism ... See full document
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Total saponin from Anemone flaccida Fr Schmidt abrogates osteoclast differentiation and bone resorption via the inhibition of RANKL induced NF κB, JNK and p38 MAPKs activation
... transcription factors, such as c-Fos, NFATc1 and ...induces osteoclast differentiation from BMMs even in the absence of RANKL ...to regulate osteoclast diffe- rentiation after RANKL ... See full document
12
Bone marrow derived extracellular vesicles activate osteoclast differentiation in traumatic brain injury induced bone loss
... the bone marrow cavity communicate via the release of extracellular vesicles (EVs), which are ~100 nm diameter packaged vesicles containing specific proteins, lipids, factors, and/or genetic ...that ... See full document
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Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide induced bone loss in vivo
... of osteoclast differentiation from hema- topoietic stem cell of the monocyte/macrophage lineage is dependent on stimulation by two important cytokines: macrophage colony-stimulating factor (M-CSF), which is ... See full document
9
<p>15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review</p>
... maintain bone shape, size, and structural integrity, and bone regulates mineral home- ostasis in the ...1 Bone formation and bone resorption are mediated by osteoblasts and osteoclasts, ... See full document
10
Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
... which regulate tran- scription factors involved in osteoclast differentiation ...terminal differentiation of osteoclasts ...in osteoclast-poor osteope- trosis, and ... See full document
9
Colony stimulating factors regulate the development of multinucleated osteoclasts from recently replicated cells in vitro
... can regulate the development of osteoclasts from recently replicated precursor cells in cultured fetal mouse long ...influence osteoclast formation are difficult to determine from these studies because ... See full document
6
Bisphosphonates: mechanisms of action
... on osteoclast recruitment may be direct and/or ...osteoclastic bone resorption in ...of osteoclast recruitment or survival, with a molecular weight be- tween 1 and 10 kD, released by the osteoblasts ... See full document
6
A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis
... After radiological examination, the hind paws were removed, fixed by incubation in 10% buffered formaldehyde for 48 hours and decalcified by incubation in 4.1% EDTA, 0.2% Parafor- maldehyde (PFA) in PBS at 4°C, with the ... See full document
10
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling
... abnormal osteoclast activation in RXR-KO mice, we cultured bone marrow cells in the presence of the cytokines macrophage colony-stimulating factor (M-CSF) and RANKL ...RXR-KO bone marrow were ... See full document
16
Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption
... of osteoclast precursors, RANKL induces the recruitment of adaptor molecules such as tumor necrosis factor receptor- associated factor 6, which activates multiple downstream signaling molecules including ... See full document
9
Building bone to reverse osteoporosis and repair fractures
... increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7 are FDA approved to promote spinal fusion and fracture healing, respectively, and the first FDA-approved anabolic drug ... See full document
9
DNA methylation of noncoding RNAs: new insights into osteogenesis and common bone diseases
... Noncoding RNAs (ncRNAs) are RNA molecules tran- scribed from the genome without open reading frame and protein-coding ability, but they can perform their crucial biological functions at the RNA level [15]. According to ... See full document
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