[PDF] Top 20 Cell Type Specific Effects of RNase L on Viral Induction of Beta Interferon
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Cell Type Specific Effects of RNase L on Viral Induction of Beta Interferon
... FACS with fluorescein isothiocyanate (FITC)-conjugated rat anti-mouse CD11b IgG2b (BD Pharmingen; catalog no. 557396, clone M1/70) and allophycocyanin-conjugated rat anti-mouse F4/80 IgG2b (Bio-Rad/Abd Serotec; product ... See full document
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Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
... by viral infection, but IFN- may specifically induce one or more genes that are required for full antiviral ...IFN-␣ induction is impaired in IFN- ⫺/⫺ ... See full document
6
An ITAM in a Nonenveloped Virus Regulates Activation of NF-κB, Induction of Beta Interferon, and Viral Spread
... certain cell types (38). Fur- thermore, viral ITAMs display cell type-specific kinase associa- ...B cell line (44, ...between cell types and influences the capacity of the ... See full document
12
Promotion of Alpha/Beta Interferon Induction during In Vivo Viral Infection through Alpha/Beta Interferon Receptor/STAT1 System-Dependent and -Independent Pathways
... primers specific for IFN-␣4, IFN-␣non4, IFN-, and IRF-7. Gene-specific primers were identified from publications (9, 14) and synthesized by Operon (Alameda, ... See full document
6
Reovirus Induction of and Sensitivity to Beta Interferon in Cardiac Myocyte Cultures Correlate with Induction of Myocarditis and Are Determined by Viral Core Proteins
... the effects of IFN-a/b, the infections were not harvested until 5 days postinfection to allow multiple rounds of infection through the ...decreased viral yield and, as expected, did so to a greater extent ... See full document
10
RNase L Triggers Autophagy in Response to Viral Infections
... the specific EMCV strain, the cell type, and details of how the experiments were performed, including MOI and time postin- fection when viral yields are ...different cell lines from the ... See full document
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Type 1 Interferon Induction of Natural Killer Cell Gamma Interferon Production for Defense during Lymphocytic Choriomeningitis Virus Infection
... of type 1 IFN in NK cell IFN- ␥ ...of type 1 IFN receptor-deficient compared to WT NK cells following in vitro exposure to vaccinia virus and dendritic cells ...␥ induction has been reported ... See full document
10
RNase L Mediates the Antiviral Effect of Interferon through a Selective Reduction in Viral RNA during Encephalomyocarditis Virus Infection
... of cell-free systems have suggested that 2-5A pathway-mediated antiviral activity occurs through the direct action of RNase L on viral RNA (2, 37); however, the effect of RNase L ... See full document
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Viral Interferon Regulatory Factors Decrease the Induction of Type I and Type II Interferon during Rhesus Macaque Rhadinovirus Infection
... during viral infection, type I IFNs (IFN-␣/) also have effects on NK cells (5, 50), T cells (25, 46, 65), and DCs (27, 44, 48), directly impacting the adaptive immune ...of type I IFNs by ... See full document
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Sindbis Virus Translation Is Inhibited by a PKR/RNase L-Independent Effector Induced by Alpha/Beta Interferon Priming of Dendritic Cells
... of viral RNA replication or any possible modulating effects of expressed viral proteins, we con- structed an SB-based translation reporter construct encoding a truncated nsP1/fLUC fusion protein, ... See full document
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“Self” and “Nonself” Manipulation of Interferon Defense during Persistent Infection: Bovine Viral Diarrhea Virus Resists Alpha/Beta Interferon without Blocking Antiviral Activity against Unrelated Viruses Replicating in Its Host Cells
... via cell division rather than via the extracellular space and that BVDV is largely resistant to IFN over several generations of persistently infected ...virus type 3 replication was not affected ...Mx ... See full document
10
Ross River Virus Envelope Glycans Contribute to Type I Interferon Production in Myeloid Dendritic Cells
... that viral complex/hybrid N- linked glycans promote IFN- ␣ /  responses in mDCs, which implicates a couple of potential mechanisms underlying this ...CD11c-positive cell populations in the mDC cultures ... See full document
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A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection
... host cell requirements for replication, and how virus-host interactions impact pathology, remain to be fully ...antiflaviviral effects, and this inhibitory activity extended to other viruses, including ZIKV, ... See full document
15
Identification of RNase L Dependent, 3′ End Modified, Viral Small RNAs in Sindbis Virus Infected Mammalian Cells
... of viral small RNAs by knocking down Drosha, Dicer, and ...another RNase. We discovered that the RNase L endonuclease is implicated in SvsRNA ...Sindbis viral small RNAs detected by ... See full document
10
Cell-Type-Specific Activation of the Oligoadenylate Synthetase–RNase L Pathway by a Murine Coronavirus
... . Olfactory bulb neu- rons may be specialized to control viruses, as they are most ex- posed to environmental factors. In addition, they continue to rep- licate in vivo in adult mice (56) and thus may tolerate higher ... See full document
11
Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... cytokine beta interferon (IFN-  ) is critical for protection against viral myocarditis in ...antiviral effects of IFN-  than myocarditic reoviruses in primary cardiac myocyte ...cultures. ... See full document
6
Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
... of RNase L itself. In RNase L ⫺/⫺ MEFs, WNV yields were increased 5- to 10-fold compared with those of WT MEFs ...negative RNase (99) or siRNA knockdown of RNase L ...of ... See full document
10
RNase L is a negative regulator of cell migration
... RNase L is a regulated endoribonuclease that functions in the interferon antiviral ...of RNase L by 2’, 5’-oligoadenylates has been linked to apoptosis, autophagy and ...the ... See full document
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Studies on the role of the 2'-5'-oligoadenylate synthetase-RNase L pathway in beta interferon-mediated inhibition of encephalomyocarditis virus replication.
... This included the observation that 2-5A accumulates in IFN-treated EMCV-infected cells 14, that RNase L is activated in such cells 37, that the inhibition can be partially reversed by an[r] ... See full document
7
Type I Interferon Response Limits Astrovirus Replication and Protects against Increased Barrier Permeability In Vitro and In Vivo
...  induction occurs late in infection and is independent of replication ...the viral life cycle inhibited by IFN-  . Viral entry was not inhibited, since positive-strand HAstV-1 RNA levels were not ... See full document
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