[PDF] Top 20 Cellular protein modulates effects of human immunodeficiency virus type 1 Rev.
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Cellular protein modulates effects of human immunodeficiency virus type 1 Rev.
... Since YL2 is most likely the murine homolog of p32 35, an acidic protein that copurifies with alternative splicing factors SF2/ASF 17, 35, our finding supports a role for Rev in the earl[r] ... See full document
7
Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localization
... that cellular phenotype may alter the requirement for Vpr during the course of productive viral replication ...that cellular phenotype and hence specific interactions with selected cellular pro- ... See full document
16
The Carboxy-Terminal Region of the Human Immunodeficiency Virus Type 1 Protein Rev Has Multiple Roles in Mediating CRM1-Related Rev Functions
... of Rev for ...the Rev protein affects its affinity for hCRM1 because this region is located just after the leucine- rich activation domain (NES), which is directly bound by ...Since Rev binds ... See full document
11
Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange.
... Plasmid pIW15 represents a Rev trans-activator protein which exerts Rev activity via an activation domain originating from HTLV-I Rex, while the Rex derivative pIW17 acts on the HTLV-I R[r] ... See full document
5
Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
... The hybrid protein bearing the basic domain of the visna virus Rev protein and the leucine domain of HIV-1 Rev, termed L/Rev, proved fully able to trans activate visna virus structural p[r] ... See full document
5
Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.
... Since the mRNAs using the competing SA4a, SA4b, SA4c, and SA5 splice sites are multicistronic, potentially coding several proteins from each mRNA 15, 48, 49, we examined the effect of al[r] ... See full document
14
Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.
... The phenomenon by which one protein facilitates the inter- nalization of another protein has also been observed in anthrax toxins. The protective antigen of anthrax toxin can form ion- conductive channels ... See full document
5
Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein.
... We have measured the levels of mRNAs produced by the HIV-1 provirus as distinct groups and have verified that all of the small, multiply spliced species are decreased by Rev to a similar[r] ... See full document
8
Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity
... The experiments presented here render the original hypoth- esis unlikely and show that target cell CypA interaction with HIV-1 CA is important for viral infectivity. We were, in fact, unable to detect any ... See full document
9
Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines.
... In this study, we have analyzed the effects of Tat on the expression of TNFa and TNFI, IL-la and IL-1p, and IL-6 during acute HIV-1 infection in T cells chronically infected with a pol-d[r] ... See full document
9
Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism.
... The human CD44 molecules (previously known as Pgp-1, HCAM, Hermes antigen, and the lymphocyte homing recep- tor) are a family of related glycoproteins formed by alternative RNA splicing (17, 26, 34, 36, 48, ... See full document
6
trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes.
... We conclude that the dominant negative phenotype of C-terminal Rev mutants reflects their ability to form nonfunctional complexes with the wild-type protein and perhaps with unidentified[r] ... See full document
7
Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.
... Tat protein in cell extracts from HeLa cells is dependent on functional Tat and on the TAR element (14, 16) and is due to the increased processivity of complexes initiating at the HIV-1 promoter ...(wild ... See full document
5
The Rev protein of human immunodeficiency virus type 1 counteracts the effect of an AU-rich negative element in the human papillomavirus type 1 late 3' untranslated region.
... of human papillomaviruses (HPVs), which cause a vari- ety of proliferative epithelial lesions ...that virus production is linked to the differ- entiation stage of the epidermal ...certain cellular ... See full document
14
Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vif Protein
... proteins Rev and Tat (17, ...wild type to mutated ...of virus produced in the presence of the wild-type protein alone (data not ... See full document
7
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
... The human immunodeficiency virus type 1 initially assembles and buds as an immature particle that is organized by the viral Gag ...capsid protein CA, which forms the central ... See full document
12
Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.
... The rex genes encoded by the mutant clones pLHRexM2, pLHRexM7, and pLHRexM8 were able to inhibit wild-type function of the HIV-1 Rev protein Fig.. The expression of Rev was Mnonitored by[r] ... See full document
8
Human Immunodeficiency Virus Type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains
... viral protein, respectively, revealed that Nef activi- ties in receptor transport are largely independent of its raft association ...the cellular Pak2 kinase strictly occurs within membrane microdomains, ... See full document
12
RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo.
... were Rev responsive, the reporter plasmids were cotransfected with a Rev expression plasmid (pRSV-Rev [20]) and CAT activities were assessed ...a Rev-responsive reporter plasmid (pDM128 or ... See full document
9
Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Its Own Translation
... different protein and RNA prepara- ...Gag protein in the reactions. The full-length protein and near-full-length C-terminally truncated species are characteristic of ... See full document
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