[PDF] Top 20 Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
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Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
... CAR T cells targeting diasialoganglioside (GD2) antigen and L1-cell adhesion molecule (L1CAM) were generated for treatment of neuroblastoma ...CAR-modified T cells resulted in a durable ... See full document
7
Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells
... NKG2D.CAR-NK-92 cells, we established a subcutane- ous xenograft model in NSG mice with CD73 + human lung carcinoma A549 ...A549 cells were subcutaneously injected (sc) into the right flank of the mice (day ... See full document
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T cell receptor-engineered T cells for leukemia immunotherapy
... Currently, T cell immunotherapy has focused on chi- meric antigen receptor (CAR)- and T cell receptor (TCR)- engineered T cells in which T ... See full document
7
Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor
... LNCaP cells compared to DU-145 cells. The use of mock-transfected cells revealed no difference between positive and negative ...when engineered T cells faced the target ... See full document
8
Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
... enormous progress was witnessed in the aspect of CAR-T therapy for ...tive T cell immunotherapy, has become more and more important in the treatment of ...CLL cells in R/R patients, ... See full document
12
Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... CAR-T cells can occasionally pose serious or even fatal threats ...genetically engineered T cells retargeting carbonic anhydrase IX (CAIX) in the treatment of metastatic renal cell ... See full document
10
Abstract: Despite advances in the understanding of its molecular pathophysiology, prostate cancer
... prostate cancer remains largely incurable, highlighting the need for novel ...a chimeric antigen receptor (CAR) specific for prostate specific membrane antigen (PSMA), a glycoprotein ... See full document
14
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
... meso-CAR T cells to lyse mesothelin-positive tumor ...CAR T cell therapy is that OAds recognize and infect tumor cells using different antigens from the ones that CAR T cells ... See full document
18
CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy
... Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malig- nancies ranging from hematological to solid ...of cancer immunotherapy is transfer of ... See full document
17
Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
... CAR-T cells to the tumor sites is often inefficient owing to the reasons mentioned ...CAR-T cells against hematological malignancies is at least partially attributed to the fact that tumor and ... See full document
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T cells expressing chimeric antigen receptor promote immune tolerance
... of T cells to direct their activation to specific targets in vivo has become a success- ful strategy for cancer immunotherapy, but relatively less is known about how adoptive transfer of ... See full document
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Chimeric antigen receptor T cells: a novel therapy for solid tumors
... ferentiation antigen, which derived from the 69-KDa precursor protein encoded by Mesothelin gene [81, ...the receptor of CA125/MUC16, and the interaction be- tween mesothelin-CA125 mediates cell adhesion ... See full document
13
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
... of cancer: melanomas and pancreatic ...and cancer immunotherapy: 1) low number of tumor antigen-specific T cells due to clonal deletion; 2) poor activation of innate immune ... See full document
9
Targeting FLT3 in acute myeloid leukemia using ligand-based chimeric antigen receptor-engineered T cells
... novel immunotherapy strat- egy CAR-T cells have revolutionized leukemia treatment, especially CD19 ...CAR-T. Chimeric antigen receptor (CAR) is an artificial structure ... See full document
12
Car Drivers and Fuel Sources: How Distinct Signaling Domains in Chimeric Antigen Receptors Reprogram T Cells
... for cancer involves surgical resection, chemotherapy or radiation either alone or in ...surrounding cells and may have little influence on metastasized tumor masses, thereby yielding unsatisfactory ...of ... See full document
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Rejection of Experimental Hodgkins Lymphoma by T Cells Engineered with a CD19 Chimeric Antigen Receptor
... T cells engineered to express chimeric antigen receptors (CARs) combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) signaling domain for ... See full document
9
Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects
... CAR-based T cell therapies, and improve their properties for a variety of ...CAR-T cells with powerful cytokine production (for example: CD3ζ- CD28-OX40 or CD3ζ-CD28-41BB) ...CAR-T ... See full document
13
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
... human T lymphocytes and facilitate the maintenance of natural phenotype and antigen specifi- city ...transduced cells apoptosis in vitro and in vivo with a 10 nM dose of AP1903 ...untransduced ... See full document
11
Cancer biomarkers for targeted therapy
... or cancer biomarkers are major targets for cancer ...targeting cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bispecific T cell engagers (BiTEs), and ... See full document
7
Universal CARs, universal T cells, and universal CAR T cells
... approved T cell products with chimeric antigen receptors (CAR) are from autologous T ...CAR T cells approved for clinical use must be generated on a custom-made ...autologous ... See full document
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