[PDF] Top 20 Cold induced changes in gene expression in brown adipose tissue, white adipose tissue and liver

... directing liver gene expression ...HNF4a expression was detected ...by cold stress including constitutive androstane receptor (CAR; Nr1i3,80 fold)and pregnane6 receptor (PXR; NR1i2; 28 ... See full document

... target gene expression was assessed in 3T3-L1 adipocytes and HepG2 hepatic cells in ...the expression levels of LXR-related genes were ...The expression levels of LXR target genes were ... See full document

... in white fat pads ex ...reduces tissue triglyceride stores compared with pair-fed controls, already suggesting a role for leptin be- yond its appetite-reducing properties (25, ...creased expression ... See full document

... SV40T-immortalized brown adipocytes from the C57BL/6J strain of mice were provided by ...are induced in BAT of wild-type C57BL/6J mice after expo- sure to cold for 4 ...and liver obtained from ... See full document

... to cold environment stimulates the action of BAT and initiates the browning of ...[8,48]. Cold condition acts as a stimulus to produce beige ...to cold environments ...the cold-induced ... See full document

... in adipose tissue from lean and obese animal models (8), or following treatment of obese animals with members of the thiazo- lidinedione class of antidiabetic agents (9), have pointed to striking regulation ... See full document

... by cold exposure in brown and beige adipocytes to support mitochondrial biogenesis [15, ...study, cold exposure altered the expression of genes involved in thermogenesis, mitochondrial ... See full document

... tween white and brown adipocyte. In mice and rats, ex- posure to cold or β-adrenergic agonists induces the appearance of brown adipocyte in traditional white fat pats, which originate ... See full document

... in liver is inhibited, which subsequently suppresses fat accumulation ...in adipose tissue inhibits PPARγ and adipogenesis, thereby reducing fat accumula- tion ...protein expression of the ... See full document

... and gene expression, changes to adipokine secretion, alterations in the lipidome of scWAT and an increased beiging of scWAT in ...that adipose tissue plays an important role as a major ... See full document

... UCP1 expression following chronic JWH-015 treatment is in agreement with a previous study showing no change in UCP1 expression in CB2 -/- mice fed a high fat diet despite a significant increase in overall ... See full document

... subcutaneous adipose tissue samples (from the abdominal wall at the edge of the surgical incision), and omental adipose tissue samples were all ...The adipose tissues were flash frozen ... See full document

... the changes described ...stage adipose tissue distribution tends to be more per- ipheral (femoral and gluteous) than ...in adipose tissue distribution, it was observed that subcutaneous ... See full document

... through-life expression of GLO-1 siRNA and mild Glo-1 defi- ciency, compared to wild-type controls [15], and decreased weight gain in Glo-1 overexpressing transgenic mice [16], sug- gesting a functional role of ... See full document

... Our previous research indicated that high-fat diet (HFD) might increase the apoptosis of brown adipo- cytes by up-regulated apoptosis-inducing factor 1 (AIF1). Besides, HFD also activated fatty acid β-oxidation ... See full document

... These results seem to suggest that 11β-HSD1 inhibition is a potential therapeutic target for treating metabolic syn- dromes. In this study, we explore whether PF915275 (PF; 4′-cyano-biphenyl-4-sulfonic acid ... See full document

... be induced at an even earlier time point than mRNA expres- ...protein expression of Lp- PLA2 likely reflects the exogenous Lp-PLA2 available, while the mRNA expression represents the newly ... See full document

... are induced to differentiate into adipocytes, UCP1 will be exclusively expressed in Rb -/- ...higher expression level of ...are induced to differentiate into adipocytes, UCP1 is elevated only in Rb ... See full document

... The nutritional intervention consisted of a spread with increased levels of medium chain triglycerides, short-chain polyunsaturated fatty acids (PUFA: C18:2 and C18:3) and conjugated linoleic acid (CLA: C18:2) (further ... See full document

... We demonstrate in a large animal that brown adipose tissue mitochondrial uncoupling protein is highly abundant in sternal adipose tissue and could contribute to the thermogenic response [r] ... See full document