[PDF] Top 20 A Computational and Experimental Model of the Epithelial Mesenchymal Transition.

... the model is now a reversible bistable switch with respect to TGF- β due to the presence of the threshold, ...from epithelial to mesenchymal with the addition of TGF-β, but now, if the concentration ... See full document

... Matrigel-based epithelial plug is embedded in additional collagen, with or without ...fibroblasts. Epithelial cells then invade in a star-burst manner into surrounding ... See full document

... immunohistochemical staining and staining intensity was scored in a standard manner as described previously. 18 Higher protein expression of MTF2 in HCC tissues than in normal tissues was further con- fi rmed by ... See full document

... This article does not contain any studies with human partici- pants performed by any of the authors. All animal experi- ments in this study were con fi rmed that ethical and legal approval was obtained prior to the ... See full document

... the transition from the epithelial to mesenchymal phenotype, and the reverse ...normal-like epithelial cells undergoing ...the mesenchymal phenotype in primary tumors and metastases may ... See full document

... The miR-200 family includes miR-200a, miR- 200b, miR-200c, miR-141, and miR-429, all of which are significantly downregulated in PCa. Each of these miRNAs has been reported to suppress PCa metastasis via EMT inhibition. ... See full document

... 2 experimental variants: a direct incubation of nuclear extracts with the FTS-1 oligonucleotide; and an indirect approach using the flow-through from an initial incu- bation with the mutant tetramer for a ... See full document

... mouse model of gas- tric cancer, it could be shown that EMT cooperates with MMP activity to gain access to lymph vessels and to spread distant metastases ... See full document

... of Epithelial-to-Mesenchymal Transition (EMT) and its ...hybrid epithelial/mesenchymal (E/M) phenotype that has maximum cellular plasticity and allows migration of Circulating Tumor ... See full document

... to experimental or approved therapeutic agents including rapamycin, as well a rapalogs everolimus and temsirolimus ...as epithelial or mesenchymal based on their transcriptional profiles using genes ... See full document

... The epithelial cobble- stone growth pattern is held together by cell adhesion molecules (claudins and ...anchors epithelial cells, through hemidesmosomes, to the ECM and provide their apical-basal ...from ... See full document

... While immortalised cell lines can shed light on diseases, particularly if there is a specific triggering element or condition which can be applied to the cells, in cases such as COPD where the exact mechanisms and causes ... See full document

... Epithelial cells of nasal polyps showed an abnormal expression α-SMA and when they were cultivated in hypoxia condition, EMT was induced via a SMAD3-dependent mechanism suggesting the crucial role for EMT in the ... See full document

... hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition ...combine epithelial and mesenchymal features and tend to migrate collectively ... See full document

... interactions between tumor-associated macrophages and CD44-expressing malignant cells promote tumorigenicity in colorectal cancer. 73 Crosstalk between stromal fi bro- blasts and colorectal cancer cells also promotes EMT ... See full document

... to epithelial cells the ability to undergo transdifferentiation into fibroblasts and consecutive activation through the process of epithelial – mesenchymal transition ...during ... See full document

... the mesenchymal phenotype due to external signals from the microenvironment and conserve the newly acquired invasive proper- ties in the absence of an extracellular cue suggests that the switch from the ... See full document

... There are both similarities and differ- ences between the TM4SF5-induced EMT of SNU449 cells reported in this issue by Lee et al. (15) and the EMT models of mam- mary gland or hepatic origin (Table 1). In all EMT models,  ... See full document

... of epithelial specific gene E-cadherin, and induces the expression of the mesenchymal specific gene ...of epithelial phenotype to repress E-cadherin expression, and NF-B has been found to induce the ... See full document

... HCV is a member of the Flaviviridae family of viruses in the hepacivirus genus, HCV infection is a major cause of chronic liver diseases, cirrhosis and HCC. End-stage liver disease caused by chronic HCV infection is the ... See full document