[PDF] Top 20 Computational Methods in Linear B cell Epitope Prediction
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Computational Methods in Linear B cell Epitope Prediction
... called B-cell epitope or antigenic determinant. B-cell epitopes can be linear or ...experimental methods of identifying epitopes are costly and time consuming, ... See full document
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Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach
... potential B-cell linear epitope regions, B-cell discontinuous epitopes as well as interferon-γ-inducing ...host cell line ... See full document
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B-Pred, a structure based B-cell epitopes prediction server
... a B-cell ...named B-Pred, is accessible on the Internet at ...the prediction of potential linear epitopes, as opposed to discontinuous ...a linear epitope to a peptidic ... See full document
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IN-SILICO T-CELL EPITOPE PREDICTION TOOL OF HEPATITIS C VIRUS (HCV)
... The SVMs classify and break off a given set of binary labeled trained data with a hyper-plane that is maximally distant from them and this simply means “the maximal margin hyper-plane”. However, if there is no ... See full document
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Prediction of linear B-cell epitopes of hepatitis C virus for vaccine development
... identifying linear B-cell epi- topes that can stimulate B-cell response, is one of the major tasks to design peptide-based vaccine; there are only few researches to analyze the ... See full document
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Computational Approach Used For Designing Of Potential B Cell Epitope Based Vaccine Construct Against Plasmodium Falciparum
... of B cell epitopes that can induce humoral immune ...several B cell epitopes were identified from different antigens of pre-erythrocytic stage, asexual pre-erythrocytic and sexual erythrocytic ... See full document
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In silico-based vaccine design against Ebola virus glycoprotein
... an epitope-based peptide vaccine against EBOV, using a combination of B-cell and T-cell epitope predictions, followed by molecular docking and molecular dynamics simulation ...silico ... See full document
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ANALYSIS OF HYDROPHOBICITY AND ANTIGENICITY OF HEAT SHOCK PROTEIN 70 FROM GWD
... Dracunculusmedinensis (a little dragon from Medina) is responsible for Dracunculiasis, popularly known as “guinea worm disease”. The Cyclops is the intermediate host that ingests the larvae of parasite (D.medinensis), ... See full document
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An Integrated In-Silico Approach to Develop Epitope-Based Peptide Vaccine against SARS-CoV-2
... of epitope- based vaccine designing approach. Both B-cell and T-cell epitopes are predicted using integrated computational ...for prediction of protective antigenicity of the ... See full document
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Computer aided prediction of antigen presenting cell modulators for designing peptide based vaccine adjuvants
... many methods have been developed which have shown that adding the motif information increases the accuracy of model [56, ...A-cell epitope from non-A cell epitope more accurately in ... See full document
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Immunoinformatics Approach Identified Two Highly Conserved B and T Cell Epitopes, LEASKRWAF and DSPLEASKRWAFRTG, for Effective Vaccine Design against Ebola and Marburg Viruses
... Nowadays, epitope based vaccine design against lethal viruses through bioinformatics has become popular because of its short study time, increased strength to predict effective epitopes and the availability of ... See full document
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Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination
... if epitope spreading of anti-citrulline autoantibody responses is also associated with the development and/or clinical progression of ...as epitope specificity (Robinson laboratory, unpublished ... See full document
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Multiple linear epitopes (B cell, CTL and Th) of JEV expressed in recombinant MVA as multiple epitope vaccine induces a protective immune response
... using epitope-based vaccine strat- egies is capable of inducing remarkable humoral and cellular immune responses and provided complete pro- tection against lethal JEV challenge in mice ... See full document
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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
... In CAFA3 (2016–2017), we continued with all types of evaluations from the first 2 challenges and addition- ally performed experimental screens to identify genes associated with specific functions. This allowed us to ... See full document
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Computational Approaches in Drug Discovery: An Overview
... Docking provides a various tools for drug design and analysis. Various application of docking includes Virtual Screening, Lead Optimization, Prediction of biological activity, Blind docking, Protein-Protein ... See full document
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Multiple linear B cell epitopes of classical swine fever virus glycoprotein E2 expressed in E coli as multiple epitope vaccine induces a protective immune response
... of B-cell epitopes rE2-a, rE2-b and rE2-ba were about 41%, 40%, and 38% of total expressed proteins in ...these epitope proteins were purified by Ni 2+ -NTA resin under denaturing con- ditions ... See full document
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The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity
... the epitope of MAb 87-y-13 might lie, as described ...against cell-cell fusion by gB and gH– gL, interfering with their interaction ...consensus epitope, called the YK epitope (43) ... See full document
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Neural network for prediction of cysteine disulphide bridge connectivity in proteins
... Protein structure prediction is an important issue in the domain of medicine (e.g., design of drug) and in Biotechnology (e.g., designs of novel enzymes) which it comes to meaning when protein structure determines ... See full document
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Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs
... Notes: Animals were vaccinated using liposome entrapped, ten influenza conserved peptide cocktail vaccine intranasally and challenged with a virulent SwIAV H1N1-OH7. (A) Graph showing the average rectal temperature ... See full document
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Analysis of antibody induction upon immunization with distinct NTS DBL1α domains of PfEMP1 from rosetting Plasmodium falciparum parasites
... When comparing predicted and recognized epitopes substantial differences were found (Additional file 3). The prediction method used for this analysis identified mainly epitopes localized in the loop region of the ... See full document
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