[PDF] Top 20 Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer
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Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer
... any HIV vaccine with a protein component (for ei- ther priming or boosting) requires production of a recombinant form to mimic the trimeric, functional HIV-1 envelope spike in quantities ... See full document
15
CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity
... by soluble CD4 allows the capture of the full continuum of conformational changes, including events that follow coreceptor ...in HIV-1 ... See full document
27
Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens
... the HIV-1 envelope glycoprotein (Env) trimer include conformational and structural ...Stabilized soluble trimers such as BG505 ...for trimer populations with improved ... See full document
16
Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer
... SOSIP.664 trimer and the gp120 ...glycosylation states of the gp41 subunits of the BG505 ...native-like trimer has an elevated population of oligomannose glycans at N625 and N637, indicating steric ... See full document
16
Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer
... the trimer rather than the only possible ...the trimer. Our V1V2 mobility simulations were performed using a SOSIP trimer in order to show how fluctuations around that predominant state explain the ... See full document
17
Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
... SOSIP trimer as it is soluble, does not aggregate, and is easier to express and ...SOSIP trimer is ideally suited for further structural investigation of bNAb com- ...the HIV-1 Env ... See full document
8
Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
... any soluble gp140 trimer necessarily involves modification of the native trimer present on virions, because the soluble versions lack the transmembrane and cytoplasmic ...with soluble ... See full document
13
Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers
... of uncleaved gp140 proteins, in this case, those proteins including a Foldon sequence, yields only nonnative structures as assessed by multiple tech- niques (3, 7, 16, 19, 26, 30, ...-Fd-His trimer fraction ... See full document
22
Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors
... detailed HIV-1 Env trimer structures currently available are those of the soluble gp140 ...state 1 gp41 to explain the observed phenotypes of our gp41 HR1 ...M HIV-1 ... See full document
20
Conformational Differences between Functional Human Immunodeficiency Virus Envelope Glycoprotein Trimers and Stabilized Soluble Trimers
... well-characterized HIV-1 Env trimers (sgp140 ...the trimer axis (34–38, 43), in contrast to the more compact architecture of sgp140 ...the trimer axis (28–32, ...significant ... See full document
27
High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers
... B41 trimer but also to identify variants with improved ...and conformational integrity of Env ...intact trimer (5, 20, ...the trimer apex ...BG505 soluble SOSIP.664 trimer bound ... See full document
18
Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers
... the HIV-1 AD8 Env to inhibition by antibodies or a CD4-mimetic com- ...the trimer axis. Uncleaved Env, cross-linked and purified in parallel, exhibited a hy- drodynamic radius similar to that ... See full document
26
Efficiency of Bridging-Sheet Recruitment Explains HIV-1 R5 Envelope Glycoprotein Sensitivity to Soluble CD4 and Macrophage Tropism
... confer HIV-1 R5 macrophage tropism are focused on the Env’s interaction with CD4 and the immediate ensuing conformational changes and do not reflect major changes in envelope ...gp41 ... See full document
12
Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes
... the conformational mobility of the apex in a way that better accommodates the CDR3 loops of PGT145 and other bNAbs that recognize this region of the trimer, which can be highly flexible ...the trimer ... See full document
23
Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody
... less trimer than the ligand-free trimer at an equal ...the trimer may account for the lower anti- trimer responses observed in the PGT145-trimer complex group than in the BG505 ... See full document
16
Structural Constraints at the Trimer Apex Stabilize the HIV 1 Envelope in a Closed, Antibody Protected Conformation
... entire HIV-1 Env trimer, as shown by their profound impact on distant antigenic sites, argues against a direct role of epitope alteration as a major mechanism for the disrupted neutralization profile ... See full document
15
A stabilized HIV 1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
... The concentrated supernatant containing SOSIP.R6-IZ-CD40L fusion protein, but not SOSIP.R6-IZ and mock supernatant, also induced SEAP activity, indicating that the CD40L component was ca[r] ... See full document
15
Structure and Dynamics of HIV-1 Env Trimer
... on HIV-1 Env contains are epitopes for broadly neutralizing antibodies (bNAbs), those regions are usually conserved regions among all HIV-1 viral strain, and neutralizing antibodies targeting ... See full document
145
Conformational HIV 1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies
... the HIV-host cell interplay and HIV life ...of conformational HIV-1 Envelope proteins presented on Virus-like Particles for appropriate assessment of this molecular interaction, ... See full document
10
A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.
... virus binding to cells at virus input concentrations appropri- ate for infectivity assays, we cannot demonstrate directly that 6H10 acts by blocking HIV binding to cell surface CD4 and t[r] ... See full document
10
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