[PDF] Top 20 Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection
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Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection
... Figure 1 shows sequence comparisons for two participants, illustrating three features of env gene evolution that were observed among all participants (for complete data sets, see reference ...the changes in ... See full document
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Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection
... Enzyme-linked immunospot (ELISPOT) assays. Ex vivo measurement of T cells for gamma interferon (IFN-␥) production was undertaken as previously reported (16, 32). As previously described, specific responses of ⱖ100 spot- ... See full document
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MT 2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection
... Interestingly, 9 of the 20 patients 45% whose virus changed from an MT-2-negative to an MT-2-positive phenotype had a transient but significant increase in CD4+ lymphocyte counts between[r] ... See full document
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Laboratory tests for detection of human immunodeficiency virus type 1 infection.
... Human immunodeficiency virus type 1 (HIV-1) is a lympho- tropic retrovirus that primarily infects and destroys CD4 1 lym- phocytes ...the virus causes irreversible ... See full document
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The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid
... lentiviral infection is reliant on the cellular roles of NUP153 during nuclear transport or on other collateral pleiotropic ef- fects caused by the depletion of this multifunctional ...cellular progression ... See full document
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A Balanced Type 1/Type 2 Response Is Associated with Long-Term Nonprogressive Human Immunodeficiency Virus Type 1 Infection
... Our findings raise two important questions. First, are the anti-p24 responses seen in immunologically discordant pro- gressors protective? It is possible that the p24-specific re- sponses are of primary importance and ... See full document
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Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection
... of viral variants with increased growth ca- pacity ...increasing viral burden, and consistently detected in adults (41–43) and in infants (11, 44) who showed a rapid clinical ...a viral isolate with ... See full document
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Mononuclear Phagocyte Differentiation, Activation, and Viral Infection Regulate Matrix Metalloproteinase Expression: Implications for Human Immunodeficiency Virus Type 1-Associated Dementia
... a consistent down-regulation in MMP-9, as determined by multiple assays, including RT-PCR, ELISA, and gelatin ...HIV-1 infection is nonetheless ...the infection of host cells by HIV-1 ... See full document
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Virus Population Homogenization following Acute Human Immunodeficiency Virus Type 1 Infection
... the virus donor (24), and is followed by further ho- mogenizing selection for certain virus ...the viral genome, these homog- enizing forces appeared to act against env or closely linked sequences, ... See full document
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Genotypic Changes in Human Immunodeficiency Virus Type 1 Associated with Loss of Suppression of Plasma Viral RNA Levels in Subjects Treated with Ritonavir (Norvir) Monotherapy
... scribed above, with continued ritonavir therapy following the viral load rebound, additional mutations accumulate. Indeed, our hybridization data reveals the presence of a triple (I54V- L63P-V82A) MUT population ... See full document
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Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs
... Cell-associated viral load. A major objective of therapy initi- ation during acute HIV-1 infection is to reduce the establishment of a latently infected pool of cells, or ... See full document
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Latency in Human Immunodeficiency Virus Type 1 Infection: No Easy Answers
... additional viral replication may follow the activation of individual latently infected ...more consistent with release from a stable reservoir than with continuous low-level replication in the presence of ... See full document
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Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core
... the viral core. Mutational stud- ies of HIV-1 IN have demonstrated the pleiotropic effects of IN on different stages of the viral life cycle (10, 14, 17, 28, 44, 62, 64, 69), but to our knowledge, a ... See full document
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Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding
... that virus entry, uncoating, and early reverse tran- scription can all occur with relatively high ...HIV-1 infection that closely follow virus binding; in particular, the conversion of ... See full document
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Co infection by human immunodeficiency virus type 1 (HIV 1) and human T cell leukemia virus type 1 (HTLV 1): does immune activation lead to a faster progression to AIDS?
... clinical progression to AIDS in an African setting. We evaluated herein HTLV-1 and HIV co-infected HAART naïve adult patients, in terms of T cell phenotype, further correlating the expression of activation ... See full document
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Cellular Restriction Targeting Viral Capsids Perturbs Human Immunodeficiency Virus Type 1 Infection of Nondividing Cells
... affects viral infectivity both in dividing and in nondividing ...affect viral infectivity distin- guishably between dividing and nondividing cell types (30, 45, ...also consistent FIG. 7. The ... See full document
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Cellular and Viral Specificities of Human Immunodeficiency Virus Type 1 Vif Protein
... released virus prior to the onset of ...cytopathic changes or produce cytokines, in- terferons, or stress responses that could secondarily perturb synthesis or processing of virion components ... See full document
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Characterization of the Behavior of Functional Viral Genomes during the Early Steps of Human Immunodeficiency Virus Type 1 Infection
... the viral entry pathway, the cellular expression levels of CypA, or an indirect effect on target cell ...MAC infection is not affected by incubation with ...exception, infection of both PBLs and ... See full document
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Intrapatient Diversity and Its Correlation with Viral Setpoint in Human Immunodeficiency Virus Type 1 CRF02_A/G-IbNG Infection
... high viral setpoint ...high viral loads possessed a greater number of nonsynonymous nucleotide ...be consistent with initial strong immune pressures on the virus population until rapidly ... See full document
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Pediatric Viral Human Immunodeficiency Virus Type 1 RNA Levels, Timing of Infection, and Disease Progression in African HIV-1-Infected Children
... of infection was large (including 7 chil- dren who were infected between day 45 and month 3, 5 children who were infected between months 3 and 6, and 5 children who were infected between months 6 and ... See full document
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