[PDF] Top 20 Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1
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Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1
... utilize CCR5 is retained despite the apparent lack of the CCR5 coreceptor on FDA/H9 cells suggest that the structural requirements for specific coreceptor binding are relatively min- ...of ... See full document
6
Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
... primate immunodeficiency viruses into target cells is mediated by the viral envelope glycoproteins, gp120 and gp41, which are organized into trimeric complexes on the virion surface (2, ...the virus to host ... See full document
7
Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity
... primary T lymphocytes, some also infect cells of the mac- rophage lineage (31, ...the CCR5 chemokine receptor, whose natural ligands include the chemokines RANTES, MIP-1a, and MIP-1b (1, 6, ... See full document
5
T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use
... at 1 to 20 mg/ml, although the ability of this MAb to block infection by T-tropic isolates of HIV-1 is highly dependent on the viral isolate and the target cell (32); MAb 12G5 is even ... See full document
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Exclusive and Persistent Use of the Entry Coreceptor CXCR4 by Human Immunodeficiency Virus Type 1 from a Subject Homozygous for CCR5 Δ32
... used CCR5, BOB, and ...plasma isolate in a HOS.CD4.coreceptor assay using p24 an- tigen readout, in which CXCR4, CCR1, CCR2B, CCR3, CCR4, and CCR5 were tested (data not ...plasma ... See full document
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Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor.
... other cell surface coreceptors are required for mediating HIV entry (3, 9, 13, 17, 23, ...in cell tropism suggests that multiple cell type- specific cofactors may be ...stromal ... See full document
5
Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry
... the human immu- nodeficiency virus type 1 (HIV-1) envelope glycoproteins to initiate viral entry into target cells (1, 11, 15, 17, 20, ...their coreceptor specificity; ... See full document
7
Heterosexual Transmission of Human Immunodeficiency Virus Type 1 Subtype C: Macrophage Tropism, Alternative Coreceptor Use, and the Molecular Anatomy of CCR5 Utilization
... tropic/NSI, T-cell-line-tropic/SI, and dual-tropic ...on CCR5 in transmission apart from macrophages (with the incidental exclusion of CXCR4-using variants that generally infect macrophages ... See full document
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No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) isolates can display differences in biological properties, such as replication rate, syncytium-inducing (SI) capacity, and cytotropism ... See full document
6
Differential CD4/CCR5 Utilization, gp120 Conformation, and Neutralization Sensitivity between Envelopes from a Microglia-Adapted Human Immunodeficiency Virus Type 1 and Its Parental Isolate
... and CCR5 on the ...of CCR5, and they infected cells expressing CD4 with a chimeric coreceptor containing the third extracellular loop of CCR2b in the context of CCR5 or a CCR5 ⌬ 4 ... See full document
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Induction of Neutralizing Antibodies to T-Cell Line-Adapted and Primary Human Immunodeficiency Virus Type 1 Isolates with a Prime-Boost Vaccine Regimen in Chimpanzees
... a coreceptor for infection and infect MT2 cells; SF33 and 92HT593 can also use CCR5 as a coreceptor (data not shown) and thus are dualtropic ...within 1 month of the low-dose ...with ... See full document
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Antibody Binding and Neutralization of Primary and T-Cell Line-Adapted Isolates of Human Immunodeficiency Virus Type 1
... TCLA virus in the absence of in vivo pressure from antibody may permit the Env to divest itself of unnecessary shielding mechanisms and thereby become more sensitive to ...that continued pas- sage of PI ... See full document
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Determinants of Entry Cofactor Utilization and Tropism in a Dualtropic Human Immunodeficiency Virus Type 1 Primary Isolate
... for human immunodeficiency virus type 1 (HIV-1) tropism has been clarified recently with the discovery that chemokine receptors, members of the large seven-trans- membrane family ... See full document
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Novel Reporter T Cell Line Highly Susceptible to Both CCR5 and CXCR4 Using Human Immunodeficiency Virus Type 1 and Its Application to Drug Susceptibility Tests
... prepare cell lysates for measurement of enzyme activities, since SEAP is released into the culture su- ...phosphatase derived from fetal bovine serum in the culture ...after virus infection the cells ... See full document
7
Sensitive Cell Based Assay for Determination of Human Immunodeficiency Virus Type 1 Coreceptor Tropism
... in human immunodeficiency virus (HIV)-infected ...HIV-1 coreceptor tropism (VERITROP) based on a sensitive cell-to-cell fusion ...a cell-to-cell fusion assay ... See full document
11
Analysis of the Critical Domain in the V3 Loop of Human Immunodeficiency Virus Type 1 gp120 Involved in CCR5 Utilization
... that CCR5 utilization is influenced by the amino acid at position ...for CCR5 tropism, Val, another hydro- phobic residue, may be functionally ...via CCR5. They did not observe any effect in ... See full document
11
Heterogeneous Spectrum of Coreceptor Usage among Variants within a Dualtropic Human Immunodeficiency Virus Type 1 Primary-Isolate Quasispecies
... to coreceptor use, in order to begin to address the molecular regulation of individual coreceptor usage among related vari- ants of a dualtropic swarm, we generated two pairs of recip- rocal ...for 1 ... See full document
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The Crown and Stem of the V3 Loop Play Distinct Roles in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Interactions with the CCR5 Coreceptor
... Many studies have previously demonstrated that the gp120 V3 loop is a major determinant of HIV-1 tropism and core- ceptor usage (for a review see reference 15). The V3 loop is composed of approximately 35 residues ... See full document
5
Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures.
... Using molecular chimeras of a macrophage-tropic primary virus JR-FL and a T-cell line-adapted virus NL4-3, we have previously shown that sCD4 resistance and macrophage tropism can both s[r] ... See full document
6
Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... a different interaction of their soluble monomeric gp120 proteins with CD4 or 17b. Equilibrium binding analyses showed no difference between Bori and Bori-15 gp120s. However, kinetic analysis of surface plasmon ... See full document
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