[PDF] Top 20 Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus Type 1 Capsid

... of PDZD8 is necessary and sufficient for binding to HIV-1 CA-NC ...(w.t.) PDZD8 or the indi- cated PDZD8 variants were mixed with in vitro-assembled HIV-1 CA-NC complexes for 2 h at ... See full document

... of human immunodeficiency virus (HIV) (Pr55 Gag ) contains sufficient information to direct particle assembly events when expressed within tissue culture ...the type C avian and mammalian ... See full document

... A series of deletions was introduced into the CA domain of the human immunodeficiency virus type 1 Gag polyprotein to examine its role in virus particle and core formation.. The mutation[r] ... See full document

... The human immunodeficiency virus type 1 initially assembles and buds as an immature particle that is organized by the viral Gag ...smaller capsid protein CA, which forms the ... See full document

... The observation that assembly and disassembly of purified HIV type 1 CA protein can be induced in vitro suggests an approach for identifying possible control mechanisms involved in HIV v[r] ... See full document

... 10016, 1 and Department of Biochemistry, University of Utah, Salt Lake City, Utah 84132 2 Received 14 November 2003/Accepted 24 January 2004 Retroviral tropism is determined in part by cellular restriction factors ... See full document

... neurotropic virus, human immunodeficiency virus type 1 (HIV-1) invades the brain and causes severe neuronal, astrocyte, and myelin damage in AIDS ...primary human ... See full document

... Human immunodeficiency virus type 1 (HIV-1) infection leads to depletion of T helper cells and immune dysfunction, resulting in immunodeficiency and thus vulnerability to ... See full document

... two capsid variants, A92E and G94D ...A92E capsid appears to be inherently less stable than the wild-type ...G94D capsid com- plexes also exhibit decreased intrinsic stability compared to ... See full document

... As a control for the ability of the HIV-1 envelope proteins to induce syncytia in the absence of a spreading infection, as is the case with most of the Cys mutants, we used a mutant rend[r] ... See full document

... The effect of vpu on the release of human immunodeficiency type 1 capsid proteins was examined in the presence or absence of virus-encoded envelope glycoproteins as well as in cells whic[r] ... See full document

... HIV-infected human sera, to address cross-reactivity of anti-p24 antibodies to different subtypes, and to identify new biomarkers that distinguish acute from chronic HIV infection for more accurate incidence ... See full document

... DISCUSSION In this report, we describe results indicating that while CyP A binds both Gag and mature CA protein, the two binding interactions are actually different. In GST pulldown experi- ments, WT CyP A bound both Gag ... See full document

... by human immu- nodeficiency virus type 1 ...leukemia virus (MLV) was ...matrix, capsid, or integrase became less sensitive when the latter two elements were ...Two capsid ... See full document

... viral capsid protein (CA) as a key determinant of cell-cycle-independent infection by human immunodeficiency virus type 1 ... See full document

... of capsid-like particles into small, non-scattering subunits (like CA ...the capsid-like parti- cles through a medium-sized intermediate that would con- tribute roughly half the total light ... See full document

... in human and simian cells, replication-competent gag chimeric viruses between HIV-1 and SIV MAC are important ...chimeric virus that carries the HIV-1 gag CA region in an SIV MAC background ... See full document

... at 1:2 and 1:4 ratios, very little restriction was observed in both ...the virus population with sCA would infect both TRIM5 ␣ cells and control cells equally well, whereas the virus ... See full document

... of human immunodeficiency virus type 1 has evolved a structure that is minimally immunogenic while retaining its natural function of receptor-mediated virus-cell ... See full document

... pooled human anti-HIV-1 serum, only supernatant from cells trans- fected with MHGag contained detectable amounts of particu- late antigen that was reactive with the ... See full document