[PDF] Top 20 Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion
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Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion
... the fusion loop membrane ...the fusion loop becomes exposed on the viral ...E protein, and the fusion loop inserts into the outer lipid leaflet of the host cell endo- somal ... See full document
7
Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein
... TBE virus, this loop is four residues shorter and forms a tight  -turn ...the structure of DEN-2 sE in the postfusion conformation (36), none of the neutralization-escape mutations in domain ... See full document
9
Subdomain Folding and Biological Activity of the Core Structure from Human Immunodeficiency Virus Type 1 gp41: Implications for Viral Membrane Fusion
... The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of two subunits, gp120 and ...the fusion-active conformation of the ...the ... See full document
6
The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane
... their envelope with the host membrane to deliver their genomes into target cells, making this es- sential step subject to interference by antibodies and ...Viral fusion is mediated by a viral surface ... See full document
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The Membrane-Proximal “Stem” Region Increases the Stability of the Flavivirus E Protein Postfusion Trimer and Modulates Its Structure
... FIG 1 Schematic representations of the flavivirus E ...for protein E: domain I (DI), red; domain II (DII), yellow; domain III (DIII), blue; fusion peptide (FP), orange; stem helices 1 (H1), 2 ... See full document
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Fusion-Deficient Insertion Mutants of Herpes Simplex Virus Type 1 Glycoprotein B Adopt the Trimeric Postfusion Conformation
... the fusion of viral and cell membranes during entry of ...for membrane fusion; the gH/gL heterodimer is also ...The crystal structure of the herpes simplex virus type ... See full document
12
The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane
... their envelope with the host membrane to deliver their genomes into target cells, making this es- sential step subject to interference by antibodies and ...Viral fusion is mediated by a viral surface ... See full document
18
Structure of a Dengue Virus Envelope Protein Late-Stage Fusion Intermediate
... he membrane-spanning envelope glycoprotein protein (E) of flaviviruses is both the principal determinant of icosahe- dral virion assembly and the fusion catalyst for merging viral and target ... See full document
7
Structure of the St. Louis Encephalitis Virus Postfusion Envelope Trimer
... encephalitis virus (SLEV) is a mosquito-borne flavivirus responsible for several human encephalitis outbreaks over the last 80 ...dimeric envelope (E) proteins that mediate attachment and fusion with ... See full document
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Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation
... GP2 structure [17]), and a short C-terminal ␣-helix (residues 399 to 408) ...“stutter” structure, which is common throughout class I viral fusion proteins ...I fusion glyco- protein. ... See full document
6
Membrane Topology and Function of Dengue Virus NS2A Protein
... E protein expression using an IFA assay ...day 1 to 4 ...in virus assembly/release. In agree- ment with the IFA result, mutant virus P85A displayed plaque morphology similar to that of the WT ... See full document
14
Crystal Structure of the West Nile Virus Envelope Glycoprotein
... lipid membrane with quasi-icosahedral symmetry (22, ...influenza virus, human immunodeficiency virus, and alphaviruses), as it lacks spikes or ...the structure of M remains unknown, structures ... See full document
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Epitope Determinants of a Chimpanzee Fab Antibody That Efficiently Cross-Neutralizes Dengue Type 1 and Type 2 Viruses Map to Inside and in Close Proximity to Fusion Loop of the Dengue Type 2 Virus Envelope Glycoprotein
... influenza virus neuraminidase ...flavivirus fusion loop directly participates in the low-pH-induced membrane fusion believed to take place following viral ...triggered membrane ... See full document
10
Studies of the conformation-dependent neutralizing epitopes of simian immunodeficiency virus envelope protein.
... We now present data showing that on the basis of fractionation of infected macaque sera, protease digestion of the envelope, and binding properties of two neutralizing monoclonal antibod[r] ... See full document
8
SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
... for 1 h at room temperature with anti-HIV-1 Env monoclonal antibodies (MAbs) recognizing the coreceptor binding site (17b), CD4-binding site gp120 epitopes (VRC03, F105, and b12), gp120 V3 glycans (19b, GE2 ... See full document
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Demonstration of binding of dengue virus envelope protein to target cells.
... lope protein and human IgG contain consensus sites for N- linked ...weight, protein A-purified env-IgG was digested with the endoglycosidases PNGaseF (cleaves all classes of N-linked carbohydrate chains at ... See full document
8
In Vitro Reconstitution Reveals Key Intermediate States of Trimer Formation by the Dengue Virus Membrane Fusion Protein
... E protein. At the top is a linear diagram of the full-length DV2 E protein, with DI indicated in red, DII in yellow, the fusion loop in green, the DI-DIII linker in cyan, DIII in dark blue, and the ... See full document
11
Regulation of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion by a Membrane-Interactive Domain in the gp41 Cytoplasmic Tail
... distal, membrane-interactive element in the HIV-1 CT can reduce Env fusogenicity is highly reminis- cent of the case for other retrovirus Envs, including those of murine leukemia viruses, Mason-Pfizer ... See full document
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Identification of a membrane fusion domain and an oligomerization domain in the baculovirus GP64 envelope fusion protein.
... GP64 envelope fusion protein (GP64 EFP) is the major envelope glycoprotein of the budded virion and has been shown to mediate acid-triggered membrane fusion both in virions and ... See full document
13
A herpesvirus vector for expression of glycosylated membrane antigens: fusion proteins of pseudorabies virus gIII and human immunodeficiency virus type 1 envelope glycoproteins.
... In particular, we present the construction and analysis of three infectious PRV mutants expressing chimeric viral membrane proteins composed of portions of the PRV envelope glycoprotein [r] ... See full document
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