[PDF] Top 20 Current status of haploidentical stem cell transplantation for leukemia

Current status of haploidentical stem cell transplantation for leukemia

... effector cell and its beneficial use oth- erwise acute GVHD have yet to be ...of cell therapy, including NK/Tregs[59] and MSC[60] infusion, have recently been used in human clinical ... See full document

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Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

... lymphoblastic leukemia; allo-SCT: Allogenic hematopoietic stem cell transplantation; ATG: Anti-thymocyte globulin; BM: Bone marrow; Bu: Busulfan; c: Chronic; CAR: Chimeric antigen receptor; ... See full document

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Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors

... Based on a study by Esteves et al., transplant-associated fatalities due to bacterial sepsis, pulmonary aspergillosis, viral infections, toxoplasmosis, and severe GVHD can negatively inﬂuence a patient’s prognosis with ... See full document

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Promise of Autologous Bone Marrow Stem Cell Transplantation to Patients with Spinal Cord Injury-Current Status

... for stem cell therapy in SCI patients has more ...BMC transplantation for hematological ...made cell therapy using BMCs widely applicable and investigated clinically in various neurologic ... See full document

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Second Allogeneic Hematopoietic Stem Cell Transplantation for Relapse after Initial Allogeneic Transplant in Childhood Leukemia - A Single Center Experience

... Hsct, stem cell source for the second Hsct, disease status at the second Hsct, conditioning regimen for the second Hsct or GVHd after the second Hsct, complete remission or chronic phase at the ... See full document

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Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMT

... the current strategy for manage- ment of AML in CR1 should incorporate auto-HSCT in patients with good- and intermediate-risk cytogenetics, especially for those lacking a fully HLA-matched ...MRD status and ... See full document

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Favorable outcome of haploidentical hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia: a multicenter study in Southwest China

... lymphoblastic leukemia (ALL) express the onco- genic BCR-ABL protein, which results from a 9;22 chromosomal translocation known as the Philadelphia (Ph) chromosome ...hematopoietic stem cell ... See full document

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<p>Decitabine-Containing Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Intermediate- and High-Risk Myelodysplastic Syndrome/Acute Myeloid Leukemia: Potential Decrease in the Incidence of Acute Graft versus Host Disease</p>

... Decitabine, a hypomethylation agent, can incorporate into deoxyribonucleic acid (DNA) and subsequently bind to DNA methyltransferase (DNMT) covalently. At high con- centrations, the predominant effect appears to be ... See full document

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Limbal stem cell transplantation: current perspectives

... of stem cells located in the ...limbal stem cell deficiency ...membrane transplantation, could be sufficient to restore a healthy ...LSCD, stem cell transplantation is ... See full document

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<p>Role of Stem-Cell Transplantation in Leukemia Treatment</p>

... Abstract: Stem cells (SCs) play a major role in advanced fields of regenerative medicine and other research ...this, stem- cell transplantation is a cellular therapeutic approach to restore ... See full document

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Haploidentical hematopoietic stem cell transplantation without total body irradiation for pediatric acute leukemia: a single-center experience

... blood cell separator (COBE Spectra LRS, Ceridian BCT, ...the stem cells by density gradient sedimentation with Hespan according to the manufacturer’s instructions ... See full document

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Haploidentical stem cell transplantation in two children with mucopolysaccharidosis VI: clinical and biochemical outcome

... The current patients are expected to develop disease specific symptoms later in childhood or adolescence considering the predicted mild to intermediate pheno- ... See full document

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Pharmacokinetic targeting of intravenous busulfan reduces conditioning regimen related toxicity following allogeneic hematopoietic cell transplantation for acute myelogenous leukemia

... oral busulfan without PK targeting and cyclophosphamide (Bu/Cy). The t-IV Bu/Flu conditioning regimen incorporated fludarabine, 40 mg/m 2 infused over 30 minutes on days -6 to -3, then intravenous busulfan, 130-145 ... See full document

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A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia

... The EBMT is a non-profit, scientific society representing more than 600 transplant centers mainly in Europe. The EBMT promotes all activity aiming to improve stem cell transplantation or cellular ... See full document

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Pediatric unmanipulated haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and reduced intensity, TBI-free conditioning regimens in salvage transplantations

... of haploidentical donor was justi- fied by the unavailability of a matched donor at the time of planned ...previous transplantation in the range of ...lymphoblastic leukemia relapsing after SCT (UPN ... See full document

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Case Report Related HLA-haploidentical T-cell replete peripheral stem cell transplantation with a reduced-intensity conditioning regimen to treat ANKL: a case report and literature review

... fibrosis. Leukemia immunophenotyping showed that the lymphocytes accounted for about ...acute leukemia. Before the patient received the hematopoietic stem cell transplantation, chol- ... See full document

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DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation

... DNA methylation is a reversible process of attaching methyl residues to cytosines adjacent to guanines (CpGs) [5]. CpGs are distributed throughout the whole genome, including repetitive sequences, enhancers, promoters, ... See full document

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Early myeloid-derived suppressor cells (HLA-DR−/lowCD33+CD16−) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT

... from MSDs. The indications for allo-HSCT were as fol- lows: AML (n = 39), ALL (n = 29), MDS (n = 8), SAA (n = 14), and lymphoma (n = 10). Ninety-nine (99%) patients reached full donor chimerism before day 30 after trans- ... See full document

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Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

... the leukemia micro- environment might drive T cell differentiation in ...T cell distribution in AMLy truly represents T cell senescence remains an open ques- tion [8]; however, T cells in AMLo ... See full document

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Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report

... hairy cell leukemia from 2012 or earlier, as seen in the bone marrow biop- ...hairy cell leukemia ...hairy cell leukemia ...allogeneic stem cell transplant ... See full document

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