[PDF] Top 20 Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
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Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
... and function of regulatory T cells ...functional Foxp3 are afflicted with uncontrolled systemic ...the Foxp3 protein is regulated post-translationally is ...demonstrate ... See full document
86
Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration
... protein kinase C (PKC)-dependent phosphorylation in PC12 cells follow- ing neuronal growth factor (NGF) stimulation however, if PKC directly phosphorylates LMTK2 is not known [17, ...LMTK2 kinase ... See full document
9
Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... in cell-based and cell-free assays. This function is independent of the interaction of Ciz1 with p21 as both p21 Cip1 null cells as well as wild type cells showed this stimulation in the presence of ... See full document
131
The control of CD4+CD25+Foxp3+regulatory T cell survival
... dramatic T reg cell death (75–90%) in the absence of IL-2 and increasing doses of IL-2 rescued them in a concentration dependent manner ...panel). T con cells survived well ... See full document
12
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2
... or function, SOCS2 is highly expressed in iTregs and required for the stable expression of Foxp3 in iTregs in vitro and in ...+ T cells upregulated Foxp3 following in vitro TGF-b stimulation, ... See full document
11
Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation
... + cell proliferation observed in the adult SVZ may result from a shift in balance be- tween cell proliferation and differentiation and/or cell ...in cell death in the absence of Cdk2 at P8 or ... See full document
9
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells
... Treg function was related to cell death, we examined via- bility and Annexin V ...into cell cycle as measured by cell trace ...tor cell proliferation were observed in the high-salt ... See full document
12
Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... cdk2 kinase activity by p27 in primary cultures of ...muscle cell accumulation after angioplasty in the rat carotid artery (20, 23), and cdk2 ex- pression correlates with VSMC proliferation after ... See full document
9
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... that Cyclin E1 (CCNE1) was overexpressed in 30% of established ovarian cancer cell ...cancer cell lines and also did not correlate with pathological grades of ovary tumor ...reduced cell ... See full document
12
IL 2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ specific autoimmunity: implications in pathophysiology and translation to human disease
... progressive T cell-dependent destruction of the b islet cells occurs around 12 weeks of age (checkpoint 2) ...to 2 transition, a switch between regulatory and pro- inflammatory ... See full document
12
Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.
... lanes 2 and 3 with lanes 8 and 9, respectively), the mutant T278A (lanes 4 and 5) and the DM (lanes 6 and 7) failed to show detectable levels of replication ...large T Ag lacking sequences between bp 962 ... See full document
7
CXCL11 dependent induction of FOXP3 negative regulatory T cells suppresses autoimmune encephalomyelitis
... suppressor function of CXCL11 is likely the expansion of IL-10–producing Tregs, which in turn suppresses the expansion and effector functions of Th1 and Th17 (as recently demonstrated by Chaudhry et ...by T ... See full document
15
Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... as cyclin-dependent kinase 4 (CDK4), CDK6, BCL2, MET, Notch, c-MYC, AXL and FOXP1 [48, 49, ...the function of miRNAs. Anti-miRs with a 2′-O-methox- yethyl modification (2′-OM) ... See full document
13
Effect of glutamine or glucose deprivation on the expression of cyclin and cyclin-dependent kinase genes in glioma cell line U87 and its subline with suppressed activity of signaling enzyme of endoplasmic reticulum–nuclei-1
... that cyclin-dependent ki- nase-2 associates with and is regulated by the regu- latory subunits of the complex, including cyclin A or E, but activity of cyclin-dependent ... See full document
12
Genetic Evidence for a Morphogenetic Function of the Saccharomyces cerevisiae Pho85 Cyclin-Dependent Kinase
... in cell-cycle regulation. The observa- through different phases of the cell cycle, suggesting tion that deletion of PCL1 and PCL2 is lethal in a strain that cyclin binding might also confer some ... See full document
13
Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells
... of cyclin D2 in vivo has been demonstrated in knockout animal models. Cyclin D2-deficient females were sterile owing to the inability of ovarian granulosa cells to proliferate normally in response to ... See full document
11
Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Calreticulin expression is regulated by a pathway that includes CDKN2B, retinoblastoma, and E2F4. To investigate the molecular link between CDKN2B and CALR, we next examined the CALR promoter for putative transcription ... See full document
16
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3
... all T cells was reported ...conventional T cell development in their CD4-Cre Hdac3 condi- tionally deleted mice, though the mice failed to generate invariant NKT (iNKT) ...other cell types ... See full document
14
Forkhead Transcription Factors Foxp1 and Foxp4 Regulate T Cell Development and Function
... Figure 2.8. Toxoplasma gondii infection does not lead to wasting or lymphopenia in Foxp4 cKO mice. Eight-week-old Foxp4 FLOX/FLOX Cre NEG , cHET and cKO mice were infected with T. gondii by intraperitoneal ... See full document
197
Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... mutated kinase; CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal growth ... See full document
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