[PDF] Top 20 CYP2C9 ) and response ( VKORC1 ) have an
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CYP2C9 ) and response ( VKORC1 ) have an
... mutations have been linked to warfarin resistance (8, ...to CYP2C9 and VKORC1 polymorphisms, several studies have reported that a functional SNP in CYP4F2 ...warfarin response. Indeed, reduced ... See full document
315
Original Article Genotype-based anticoagulant therapy with warfarin for atrial fibrillation
... studies have demonstrated that genet- ic and environmental factors, as well as drug interactions affect the efficacy of warfarin on anticoagulation, including the genetic mutation in CYP2C9 and VKORC1 [7, ... See full document
7
Identification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy
... of CYP2C9 and VKORC1 polymorphisms on warfarin dosage in 115 Iranian patients were ...individual response to warfarin, same dosage of warfarin is not suitable and curable treatment for all patients who are ... See full document
8
Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population
... The warfarin maintenance doses of VKORC1 1173CT, 1542GC, 2255CT and 3730CT carriers and in obese patients were significantly higher than in the others. Our results indicate that the ethnic origin of the warfarin-treated ... See full document
5
Pharmacogenomics in cardiovascular disorders: Steps in approaching personalized medicine in cardiovascular medicine
... medications have been well ...in response to these medications among patients, which may be due to genetic ...with CYP2C9 and VKORC1 gene variations have a different response to ... See full document
9
Vol 8, No 4 (2016)
... warfarin response variability is associated with CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) and VKORC1 (Vitamin K epoxide reductase complex1) genetic ...of CYP2C9*2 and ... See full document
12
<p>Polymorphisms of <em>CYP2C9*2</em>, <em>CYP2C9*3</em> and <em>VKORC1</em> genes related to time in therapeutic range in patients with atrial fibrillation using warfarin</p>
... quate response based on their pharmacogenetic pro fi ...for CYP2C9*3 and VKORC1 -1639 G>A ...genes CYP2C9*2, CYP2C9*3 and VKORC with TTR ... See full document
9
<p>Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease</p>
... studies have evaluated the asso- ciation between CYP2C9 p-VNTR polymorphism and the response to warfarin using the INR outcome ...the response to warfarin during the initiation and maintenance ... See full document
8
<p>The Effect of CYP2C9 Genotype Variants in Type 2 Diabetes on the Pharmacological Effectiveness of Sulfonylureas, Diabetic Retinopathy, and Nephropathy</p>
... cell response increases in both stimulants of glucose and non-glucose ...usually have serious side effects including hypoglycemia which is more common in the long-acting version of such ... See full document
8
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... between CYP2C9 and CYP2C8 polymorphisms and response to ibuprofen therapy (ductus closure) in extremely preterm neonates diagnosed with haemodynamically significant ...the response to ibuprofen were ... See full document
8
CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment
... Additionally, response variability depends on differences in metabolism, usually caused by genetic polymorphisms. Genetic polymorphisms occurring as a result of single- nucleotide exchange in the DNA sequence are ... See full document
8
An assessment study on extraction of glucosamine from potential source and effect of glucosamine activity on administration of conventional drugs
... receptors- Cyp2C9 and Cyp3A4 with ...and Cyp2C9 receptor was increased by 20% and with Cyp3A4 receptor it was increased by 34% which indicates the decrease in affinity between ... See full document
6
Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with <em>CYP2C8*3</em> and <em>CYP2C9</em>
... and CYP2C9*1/*3 genotype) and one volunteer (CYP2C8*3 mt and CYP2C9*1/*3 genotype) reported ...or CYP2C9 was not correlated with any variation in the anti-inflammatory effects of ... See full document
9
INHIBITORY ACTIVITY ON THE HUMAN CYTOCHROME P450 AND IN VITRO CYTOTOXIC EFFECTS ON HUMAN HEPATOCYTES OF NEFAZODONE, TRIAZOLEDIONE, M-CHLOROPHENYLPIPE.......
... The antidepressant nefazodone (NFZ) determined several cases of acute hepatotoxicity/liver failure. Since the mechanism of hepatotoxicity still remains unknown, NFZ and two of its main metabolites, triazoledione (TZL) ... See full document
11
Creating and validating a warfarin pharmacogenetic dosing algorithm for Colombian patients
... Genomic DNA was obtained from patients’ blood samples using the conventional salting-out procedure. Genomic regions encompassing CYP2C9*2 (c.430C > T), CYP2C9*3 (c.1075A > C), CYP4F2 (c.1297G > A), ... See full document
10
Effect of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and meta-analysis
... Subgroup analyses will be used to explore possible sources of heterogeneity, based on the following: (1) patient char- acteristic (age, predominant ethnicity, indication for war- farin); (2) target INR (median target ... See full document
6
Original Article Effects of zedoary turmeric oil on P450 activities in rats with liver cirrhosis induced by thioacetamide
... (CYP1A2, CYP2C9, CYP2C19, CYP2B6, CYP2D6 and CYP3A4) in rats with liver cirrhosis induced by thioacetamide ...isoforms CYP2C9 and CYP2D6 in vivo in cirrhotic rats induced by TAA, while ZTO with the dose of ... See full document
9
<p>Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors</p>
... Bleeding risk of warfarin is normally evaluated using international normalized ratio (INR) as an indicator. It has been reported that the concomitant warfarin administration with tyrosine kinase inhibitors such as ge fi ... See full document
8
Genetic polymorphisms of patients on stable warfarin maintenance therapy in a Ghanaian population
... for CYP2C9, CYP4F2 and VKORC1 variants genotyped are summarized in Table ...equilibrium. CYP2C9*2, and CYP2C9*3 variant alleles were not detected in any of the patients genotyped in this study ... See full document
7
CYP2C9 Polymorphism and Unstable Anticoagulation with Warfarin in Patients Within the First 3 Months Following Heart Valve Replacement
... of CYP2C9 variants was demonstrated in a less stable anticoagulation reflected by shorter TTR and a longer period where the INR was above the thera- peutic ...with CYP2C9*2 or *3 variants are ... See full document
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