[PDF] Top 20 Cytoplasmic Forms of Human T-Cell Leukemia Virus Type 1 Tax Induce NF-κB Activation
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Cytoplasmic Forms of Human T-Cell Leukemia Virus Type 1 Tax Induce NF-κB Activation
... HTLV- 1-transformed T-cell lines, such as HUT102, MT2, and C91/ PL, express high levels of Tax protein, stable cell lines constitutively expressing wild-type Tax have been ... See full document
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Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.
... eukaryotic NF- k B/Rel transcription factors by various cytokines and mitogens is a transient event, reflecting the fact that these inducers trigger the degradation and resynthesis of the dynamic NF- k ... See full document
6
Evidence for NF-κB- and CBP-Independent Repression of p53's Transcriptional Activity by Human T-Cell Leukemia Virus Type 1 Tax in Mouse Embryo and Primary Human Fibroblasts
... for Tax (WT; ...of Tax repressed activation by approximately 70% ...by Tax in a dose-dependent manner ...three Tax mutants (to be used in later transfections) by Western blotting and by ... See full document
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The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein
... and Tax-1 colocalize. It has also been reported that Tax localization and its ability to activate NF-B are regulated by posttranslational ...these, Tax-1 phosphorylation, a ... See full document
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Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
... a Tax expression plasmid or in JPX-9 cells either induced or left uninduced, revealed that Tax was inducing VCAM-1 expres- sion in a k B-dependent ...consensus NF- k B elements, is ... See full document
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Phosphorylation of the Human T-Cell Leukemia Virus Type 1 Transactivator Tax on Adjacent Serine Residues Is Critical for Tax Activation
... the Tax mutant ...allow Tax-in- duced activation of gene expression, we replaced leucine 300 and alanine 301 in mutant F2 by charged amino acids that can function as phosphoserine mimetics (1, ... See full document
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An Alternative Splice Product of IκB Kinase (IKKγ), IKKγ-Δ, Differentially Mediates Cytokine and Human T-Cell Leukemia Virus Type 1 Tax-Induced NF-κB Activation
... a cell-type specific fashion where different abundances of IKK ␣ /  are found ...the Tax- transformed 5R cells, we compared their activities in the well- studied HepG2 cells that exhibit highly ... See full document
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The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins.
... of NF-kB proteins to the nucleus (9, 32, 36, 41, 71) followed by the formation of discrete structures in the nucleus, where Tax and NF-kB proteins ...that NF-kB p50 is normally associated with ... See full document
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Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein
... (A) Activation of the PCNA promoter by Tax ...mutant Tax protein or the pCMV-1 negative control plasmid, and 1 mg of ...Fold activation was determined by dividing the CAT ... See full document
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The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... HTLV-induced T-cell transformation re- mains unknown. Patients with HTLV-1 infection who develop adult T-cell leukemia do so after a 25- to 30-year latent ...and Tax ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Protein Abrogates Interleukin-2 Dependence in a Mouse T-Cell Line
... the cell cycle (5, ...by Tax is mediated by activation of NF-kB in the following man- ner ...3). Tax and Tax703, which are activators of NF-kB, inhibit apoptosis of CTLL-2 ... See full document
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Role of Tax protein in human T cell leukemia virus type I leukemogenicity
... manner Tax connects these activated kinases to IKKγ/NEMO and recruits their kinase activity to phosphorylate IKK and IKKβ [25,102,120- 122] which, in turn, phoshphorylate IκBα and IκBβ (see ...to Tax ... See full document
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Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
... by Tax occurs through interactions of Tax with CREB and the CREB response elements (CREs) found in three 21-nucleotide repeats in the LTR (2, 11, 55, 61, ...of Tax with C-G-rich motifs that flank the ... See full document
5
Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax Protein
... Human T-cell leukemia virus type 1 (HTLV-1) is the etio- logical agent of adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated ... See full document
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Tax 1-Independent Induction of Vascular Endothelial Growth Factor in Adult T-Cell Leukemia Caused by Human T-Cell Leukemia Virus Type 1
... Human T-cell leukemia virus type 1 (HTLV-1) is the etio- logical agent of adult T-cell leukemia (ATL) and a neurode- generative disease termed ... See full document
7
Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.
... active NF-kB dimers which can stimulate transcription (3). Tax interacts directly with the ankyrin motifs of IkB, resulting in the release and nuclear translocation of NF-kB dimers which are ... See full document
7
Mutational analysis of human T-cell leukemia virus type 2 Tax.
... (Fig. 1). Although Tax-2 binding of zinc has not been demon- strated, these results strongly suggest that Tax-2 forms a zinc finger utilizing the same amino ...LTR. Tax-2 mu- tants ... See full document
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Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.
... for Tax regulation of the PCNA promoter can be envisioned. Tax could physically bind to the protein(s) in this complex, bringing it into the proximity of the PCNA promoter where it could influence ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Dysregulates β-Catenin Signaling
... that Tax can activate this sig- naling pathway by inducing Akt phosphorylation ...that Tax-induced Akt signaling activa- tion plays an important role in the transformation of HTLV- 1-infected ...and ... See full document
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Human T Cell Leukemia Virus Type 2 Tax-Mediated NF-κB Activation Involves a Mechanism Independent of Tax Conjugation to Ubiquitin and SUMO
... C: Tax ubiquitination (Ub column) and SUMOylation (SUMO2/3 column) status is indicated by a plus ( ⬎ 100% relative intensity compared to Tax1) or minus ( ⬍ 10% relative intensity compared to Tax1) ...the ... See full document
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