[PDF] Top 20 Decoding the usefulness of non coding RNAs as breast cancer markers

... miR-155 and miR-195), prognosis (e.g. miR-29b and miR- 30 family) and prediction of response to therapy (e.g. miR- 30c and miR-221). It should be emphasized that miRNAs are easily accessible, affordable, ... See full document

... For the secondary search, we focused on RNA seq data. Statistical analysis All available lncRNAs were sorted by alteration frequency at the cBioPortal. Those lncRNAs with significant log-rank p values were entered the ... See full document

... Long non-coding RNA (lncRNA) genes are an important population of non-coding RNAs with GH¿QHG key roles in normal development as well as tumorigenesis ...of cancer stem cells. ... See full document

... these non-captured and the cor- responding captured libraries were used to evaluate the RNA CaptureSeq ...and non-captured ...and non-captured ... See full document

... 1.4. Breast cancer 1.4.1. Breast cancer epidemiology Breast cancer (BC) represents the most common non-skin malignancy in women, and it is the second cause of ... See full document

... Early menarche, late menopause and nulliparity have been linked to an increased risk of developing OC (Hamajima et al. 2012). ese factors increase the number of ovulatory cycles, implicating the role of hormones in the ... See full document

... In addition, qRT-PCR was employed to validate the microarray analysis findings, and results were consistent with the data from the microarrays. These results revealed that there were unique lncRNAs expression signatures ... See full document

... interfering RNAs, such as chemical modi fi cation and issues related to the delivery of ...cal markers can maintain their function continually, in other words, whether the effect is persistent, affects the ... See full document

... (ATM), breast cancer 1 (BRCA1), cyclin dependent kinase inhibitor 2B (CDKN2B), RB transcriptional corepressor like 1(RBL1), RB transcriptional corepressor like 2 (RBL2) and tumour protein P53 ...in ... See full document

... 29. Lin MF, Jungreis I, Kellis M. PhyloCSF: a comparative genomics method to distinguish protein coding and non- coding regions. Bioinformatics. 2011; 27:i275–i282. 30. Harrow J, Frankish A, Gonzalez ... See full document

... relatively non- invasive and easy to ...identify markers that are not only suitable for diagnosis but also can guide treatment and ...These markers correlated significantly with clinical ... See full document

... interfering RNAs Another class of small ncRNAs involved in post- transcriptional RNA silencing are so-called small inter- fering RNAs ...in cancer therapy by several ...colon cancer cells, ... See full document

... Second, we provided a new molecular classification of breast cancer using lncRNA expression. Indeed, according to this classification, we found that samples related to lncRNA clusters I and II highly ... See full document

... Abstract: Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms of biogenesis, biological function as well as length and ...promoting cancer development and ... See full document

... Aberrant expression of lncRNAs is associated with various cancers. Through regulation of gene expression and signaling transduction, lncRNAs function as oncogenes or tumor suppressors, extensively involved in the ... See full document

... in breast cancer - of the sponge mechanism involving PTENP1 - together with the previously reported growth- suppressive role of PTENP1 [22,25] - corroborates the importance of miRNA-mediated PTENP1 ... See full document

... In this study, we firstly screened considerable up- regulated and down-regulated lncRNAs using Phalanx human OneArray microarray. These lncRNAs may represent potential prognostic markers for predicting the ... See full document

... humans. A large amount of reports show that tRNAs can be cleaved into small molecule fragments under certain stress condition, called tRFs. At present, the biological function of tRFs still keeps unclear, and limited ... See full document

... the non-coding RNAs expression data can be used for a classification of the normal tissues and of the several cancers using system biology ...of non-coding RNA, as Transcribed ... See full document

... in breast cancer cell lines, through its regulatory function on PTEN and GSK3β, that are two major components of the PTEN/AKT/GSK3β signalling pathway providing feedback to TP53 ... See full document