[PDF] Top 20 Three day dendritic cells for vaccine development: Antigen uptake, processing and presentation
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Three day dendritic cells for vaccine development: Antigen uptake, processing and presentation
... Uptake of long MART-1/Melan-A peptide by 3d mDC and 7d mDC The ability of 3d and 7d mDC to take up, process and present antigen was also tested. For this purpose, a long MART-1/Melan-A peptide, consisting ... See full document
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Vaccine delivery by penetratin: mechanism of antigen presentation by dendritic cells
... the uptake, processing and presentation of AntpOVA in bone marrow-derived DC (BMDC) utilizing a number of biochemical inhibitors of the various ...T cells from OT-I and OT-II mice as readouts ... See full document
22
Preventing autoimmune arthritis using antigen specific immature dendritic cells: a novel tolerogenic vaccine
... 15-0195-treated dendritic cells inhibit clinical development of collagen-induced arthritis Type II collagen-pulsed LF 15-0195-treated dendritic cells inhibit clinical development ... See full document
11
Herpes Simplex Virus γ34 5 Interferes with Autophagosome Maturation and Antigen Presentation in Dendritic Cells
... other cells, ␥ ...affecting presentation of intracellular ...on vaccine development and antitumor therapies using HSV as an oncolytic ... See full document
9
Exploiting dendritic cells to improve vaccine efficacy
... outlined three areas of DC biology that might be exploited to improve vaccine ...enhancing antigen uptake and processing; these could be targeted to improve the presentation of ... See full document
9
Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells
... triggering processing and ...the uptake and trafficking of exogenous antigens toward the MHC class I pathway (18, ...viral antigen uptake and ... See full document
14
Cationic liposomes promote antigen cross-presentation in dendritic cells by alkalizing the lysosomal pH and limiting the degradation of antigens
... CL-based antigen delivery systems is their cytotoxicity at high ...intracellular processing of antigens and cross-presentation – parameters that need to be taken into account for the design and ... See full document
14
Targeting antigens to dendritic cell receptors for vaccine development
... B cells, activated macrophages, eosinophils, platelets, and follicular ...the cells; however, endocytosis anti-MHC class II antibody leads to recycling of HLA-DR-CD23 complex to the cell surface, consistent ... See full document
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Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes
... We developed a new 2-day protocol for the generation of dendritic cells (DCs) from human monocytes in vitro. First, we demonstrated that 24 hours of culture with GM-CSF and IL-4 are sufficient to ... See full document
7
Distinct Uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells
... improves antigen presen- tation in vitro and T lymphocyte priming in ...peptide antigen and a defined adjuvant in one single ...and processing of two TLR-L conjugates in dendritic cells ... See full document
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Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen
... the development of DC-targeting NP vaccine reagents derived from clinically relevant tumor antigens holds great ...heighten antigen uptake and subsequent CD8 + T-cell stimu- lation by DCs, ... See full document
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An investigation into IgE facilitated allergen recognition and presentation by human dendritic cells
... 1 uptake and processing by peripheral blood myeloid DCs and in the Th2 polarisation of T ...the development of Th2 responses and suggests a novel target for ... See full document
12
Ethanol Inhibits Antigen Presentation by Dendritic Cells
... endogenous antigen presentation by DCs to allogeneic T cells and exogenous OVA peptide pre- sentation to DO11 and primary CD4 ⫹ T cells are impaired during chronic ethanol consumption in ...in ... See full document
10
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
... of antigen-specific anti- body responses by particulate vaccine adjuvants, including alum and Freund’s complete and incomplete adjuvants, did not require signaling through TLRs (10, ...of antigen- ... See full document
6
Antigen processing and T cell priming by mouse dendritic cells
... BALB/c dendritic cells ...control cells of one mouse strain but not in the other; representing strain-specific genes expressed independently of ... See full document
216
SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells
... exogenous antigen presen- tation. In the absence of Vpx, antigen levels are low, and although CTL stimulation can occur through exogenous presentation of antigens, this process is less efficient than ... See full document
13
Uptake and Intracellular Trafficking of Superantigens in Dendritic Cells
... SEG Co-localizes with EEA-1, LAMP-2 and RAB-7 in the Lysosomal Compartment Laser scanning confocal microscopy was also used to investigate the location of SEG after DC uptake. For this purpose, we used markers of ... See full document
14
High-Level Antigen Expression and Sustained Antigen Presentation in Dendritic Cells Nucleofected with Wild-Type Viral mRNA but Not DNA
... 2008 Dendritic cells (DC) are potent antigen-presenting cells that hold promise as cell-based therapeutic vaccines for infectious diseases and ...the presentation of relevant antigens ... See full document
8
Antigen Processing and Presentation; Direct and Cross
... the active proteolytic subunits. Proteins are introduced into core of the proteasome for degradation then released. Three subunits of the proteasome called LMP2, LMP7 and MECL-1 are induced by interferons ... See full document
25
Vaccinia Virus Infection Attenuates Innate Immune Responses and Antigen Presentation by Epidermal Dendritic Cells
... epithelial cells and/or taking up viral antigens produced in neighboring ...sequent presentation of endogenous viral antigens to T cells in secondary lymphoid organs or else impede the skin immune ... See full document
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