[PDF] Top 20 Design, synthesis, and cytotoxicity evaluation of new 2,4-disubstituted quinazolines as potential anticancer agents
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Design, synthesis, and cytotoxicity evaluation of new 2,4-disubstituted quinazolines as potential anticancer agents
... medicinal chemists to bring molecular modifications to this nucleus to synthesize new potential medicinal agents (Ghorab et al., 2016). It is evident from the literature that the quinazoline ... See full document
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5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
... and 4, which represent all the binding energies of this compound, it is clear that the total binding energy of compound 20b equals - ...forming 4 pi-hydrogen interactions with binding energy - ...NH ... See full document
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Synthesis and evaluation of new 2,3- and 2,4-disubstituted quinazoline derivatives as potential antibacterial and antifungal agents
... aminoquinazoline 2 with aromatic aldehydes such as 2,4- dichlorobenzaldehyde, 4-hydroxybenzaldehyde in boiling ethanol yielded 2-methyl-3-(2,4- dichloro and/or ... See full document
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Design, synthesis and biological evaluation of some novel Schiff base derivatives as potential anticancer agents
... Cytotoxicity of the novel pyrrolizines (18-20) was evaluated against HEPG2 and MCF7 cancer cell lines using Sulforhodamine-B (SRB) assay method as previously reported by Skehan et al.[29]. Antitumor activity ... See full document
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Design, Synthesis and Biological Evaluation of Novel 2-Thiouracil-5-Sulfonamide Isosteres as Anticancer Agents
... vitro cytotoxicity of all the synthesized compounds against two cell lines of human cancer, namely Breast(MCF7) and Live (HEPG2) cancer obtained from pharmacology screening unit of the National Cancer Institute ... See full document
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Design, synthesis and evaluation of new 2,6-dihydroimidazo[1,2-c]pyrimido[5,4-e]-pyrimidine-5(3H)-thiones as possible antihistaminic/antiasthmatic agents?
... compounds 4a‑g designed in this study. Statistical relations (graphs) for marketed drugs and non‑drug like chemicals were created using information from the Osiris Property Explorer website. The horizontal lines in the ... See full document
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Synthesis and biological evaluation of new 2-(4-fluorophenyl) imidazol-5-ones as anticancer agents
... the design and synthesis of novel derivatives to be evaluated as anticancer agents, and exploring the plausible mechanisms by which they could exert such ...to design the new ... See full document
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Synthesis and biological evaluation of new pyrrolobenzodiazepines, tetrazoles and quinazolinone derivatives as potential anticancer agents
... a potential target area for the development of chemotherapeutic ...These agents can be categorized into functional sub groups, alkylating agents, antimetabolites, antibiotics, and ...the ... See full document
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DESIGN, SYNTHESIS, AND CYTOTOXICITY EVALUATION OF NOVEL OPEN CHAIN ANALOGUES OF ANTIMYCIN A 3 AS POTENTIAL ANTI COLORECTAL CANCER AGENTS
... Scheme 2 outlines the synthesis of analogue 1 and 2. Starting from esterification of Boc-L-threonine (8) with allyl bromide under basic condition, which was conducted according to the procedure ... See full document
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Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
... drug design and chemical organic synthesis are driven from ...of new molecules, designed in silico from the fragments belonging to (+)-calanolide A and α-APA molecules (Figure ...compounds 2 ... See full document
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Synthesis and biological screening of new 4 substit uted 2 (3,4,5 trimethoxyphenyl)quinazolines as potential anticanc er agents
... In this piece of work, we succeeded in synthesizing a new hybrid 4-substitutedaminoquinazolino-3,4,5- trimethoxyphenyl motif. The newly designed and synthesized series of compounds beard both active ... See full document
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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW PYRROLO[2,1-C][1,4]BENZODIAZEPINES AS ANTIMITOTIC AND ANTICANCER AGENTS
... Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of potent naturally occurring low molecular weight antitumour antibiotics originally isolated from various Streptomyces species. A number of naturally occurring and ... See full document
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NEWER BENZOFURAN DERIVATIVES AS POTENTIAL ANTICANCER AND ANTHELMINTIC AGENTS
... as potential therapeutic agents by anticancer ...First, 2-ethoxy carbomethoxy (1) was prepared from 2-hydroxy acetophenone and ethylchloroacetate, which gave ... See full document
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DESIGN AND SYNTHESIS OF NOVEL 2, 3 DISUBSTITUTED QUINAZOLINES: EVALUATION OF IN VITRO ANTICANCER ACTIVITY AND IN SILICO STUDIES
... Table 2. The results, the compounds 4a, 4b, 4c, 4d, 4e, 4g, and 4 h, have shown higher cytotoxic activity against all the tested cell ...Table 2: Cytotoxic activity of novel 2,3-disubstituted ... See full document
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Synthesis, characterization and in vivo biological evaluation of novel benzimidazoles as potential anticancer agents
... We investigated the anti-proliferative effect of newly synthesized benzimidazoles on HeLa cells using MTT assay. Among them, 8d proved to be very potent compound with the inhibitory concentration 50% (IC 50 ) of 25.3 μM ... See full document
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Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole 3,4 dicarboxylates
... Pyrazole and its derivatives, occupy an important posi- tion in medicinal chemistry with a wide range of bioac- tivities. They possess anti-obesity [1], receptor antago- nists [2], HIV reverse transcriptase ... See full document
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Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
... Multi-component reactions (MCR) are one-pot pro- cesses with at least three components to form a sin- gle product, which incorporates most or even all of the starting materials [1–6]. The huge interest for such ... See full document
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CHEMO-ENZYMATIC SYNTHESIS OF NOVEL PHENOLIC LIPIDS AND THEIR EVALUATION FOR ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES
... Castor oil is also known as medicinal oil since ancient times, and was primarily used as purgative to counter constipation. The activity of castor oil is due to the presence of 88-90% of a unique fatty acid, ... See full document
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Design, Synthesis, and Anti-Inflammatory Activity of Novel Quinazolines
... cyclooxygenase 2 enzyme. Compounds 4, 8, 9, 10, and 13 showed interesting anti-inflammatory activity and a good binding with the COX-2 ...anti-inflammatory agents with high binding affinity ... See full document
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Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity
... spectra of compounds were recorded on Bruker 300 MHz NMR spectrophotometer using CDCl 3 as a solvent and TMS (tetramethylsilane) as an internal standard. Mass spectra of compounds were recorded on Waters micromass Q-Tof ... See full document
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