[PDF] Top 20 Development of a foot and mouth disease virus replicon system for the study of RNA replication
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Development of a foot and mouth disease virus replicon system for the study of RNA replication
... microscope. Replicon plasmid DNAs were linearised with AscI, RNA synthesised using T7 RNA polymerase and 1 μg of transcript RNA transfected into BHK-21 ...pRbz replicon displayed ... See full document
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Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication
... the replication of positive-strand RNA viruses is key to the development of novel therapeutic strat- ...intense study, relatively little is known about the molecular interactions within the ... See full document
12
Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication
... chemical study with PV has provided in vitro evidence to suggest that 3D cannot assemble into the replication complex alone but is initially assembled as part of a larger precursor, which is subse- quently ... See full document
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Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication
... genome replication derived from work with PV require a noncovalent interaction between the 5= and 3= UTRs involving host cell and viral proteins in a ribonu- cleoprotein complex to facilitate efficient translation ... See full document
20
Pathogenesis of virulent and attenuated foot and mouth disease virus in cattle
... mutant virus was capable of establishing infection at similar primary sites as the parental virus; however, infection with the mutant was arrested at the primary infection sites by incompletely elucidated ... See full document
15
Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis
... of RNA viruses, based on their replication through complex mutant spectra that poise the viral systems close to an extinction threshold ...viral RNA during chain elongation (13, 14, ...FMDV ... See full document
17
Foot-and-mouth disease virus and poliovirus particles contain proteins of the replication complex.
... recent study we provided further evidence that 3D is a component of FMDV particles by showing that these particles react with antibody against the Escherichia coli-expressed en- zyme ...the RNA, when it was ... See full document
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Establishment of persistent infection with foot and mouth disease virus in BHK 21 cells
... Virus replication is harmful or pathological for interfering host cell functions [1], but some viruses can reside persis- tently in their host cells without causing any obvious pathological changes, and ... See full document
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Foot-and-Mouth Disease Virus Nonstructural Protein 2C Interacts with Beclin1, Modulating Virus Replication
... Reverse genetics were used to assess the effect of 2C mutations identified as critical in mediating the interaction between 2C and Beclin1. Infectious clones of FMDV O1C (5) contained areas of 2C harboring the same ... See full document
11
Biological function of Foot and mouth disease virus non structural proteins and non coding elements
... Foot-and-mouth disease virus (FMDV) represses host translation machinery, blocks protein secretion, and cleaves cellular proteins associated with signal transduction and the innate immune ... See full document
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Identification of RNA Helicase A as a New Host Factor in the Replication Cycle of Foot-and-Mouth Disease Virus
... Foot-and-mouth disease virus (FMDV), as with other RNA viruses, recruits various host cell factors to assist in the translation and replication of the virus ...this ... See full document
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Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.
... to replication and that the molecules were not affecting translation by 39UTR or 59UTR binding, we performed translation assays with bicistronic ...C virus, human rhinovirus), with similar results (data not ... See full document
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Inhibition of foot and mouth disease virus replication in vitro and in vivo by small interfering RNA
... active RNA-silencing machinery [6], besides a nonspecific, interferon mediated antiviral response mediated by dsRNA [7,8], especially by viral long (35-nt) dsRNA ...the RNA silencing machin- ery is ... See full document
6
Synthesis of new adjuvants and carriers for foot and mouth disease virus (fmdv)
... one______________________________________ Foot and mouth disease virus immunization in mice, 90% o f a ...induce virus-specific CTLs via in vivo ...influenza virus peptides ... See full document
237
The pH stability of foot and mouth disease virus
... In FMDV-infected cells, acidification in the endosomes firstly sensed by pH sensors in the FMDV capsid con- trols the switches of capsid from metastable state to the precise structure rearrangement for initiating the ... See full document
10
The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.
... picornavirus replication, since rhinoviruses and enteroviruses utilize a different proteinase (2A) to cleave ...FMDV replication, we generated synthetic FMDV genomes lacking the L gene and tested their ... See full document
7
Challenges and prospects for the control of foot-and-mouth disease: an African perspective
... the virus (A, O, SAT1, and SAT2), and maybe even five (SAT3), each with multiple subtypes in the region (Figure ...the disease is common, and SAT1 and/or SAT2 outbreaks in Mozambique, Malawi, and Zambia ... See full document
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Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.
... as disease security officer and the staff of the Synchrotron Radiation Source, Daresbury ...during virus maturation is shown as a ball-and-stick model in the color of the capsid protein in which they ... See full document
10
Modifications to the Foot-and-Mouth Disease Virus 2A Peptide: Influence on Polyprotein Processing and Virus Replication
... of virus from full-length cDNA ...FMDV RNA was introduced into BHK cells by electroporation (as described previously ...viral RNA was extracted (RNeasy minikit; Qiagen) and converted to cDNA using ... See full document
16
Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids.
... ELISA. A capture ELISA method was adopted to analyze the effects of pH treatment. In this method a rabbit anti-FMDV antiserum was used to capture antigen which was then detected by using a guinea pig anti-FMDV serum. ... See full document
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