[PDF] Top 20 Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function
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Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function
... of Tax protein ex- pression using a panel of Tax antibodies including four Tax monoclonals (Tab 169, 170, 171, and 172) from our laboratory, three antibodies (IF7, 4C5, and 9F11) from ...in ... See full document
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Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain
... certain cell types, increased expression of this protein correlates with activation and proliferation in normal T cells ...Thus Tax deregulates the normal cell cycle control in T cells ... See full document
9
Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells
... the ability of the p53 activation domain to interact with ...of p53 has been shown to interact with subunits of TFIID (TBP, human TAF32, and human TAF70), TFIIH (p62), CBP/p300, and ... See full document
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Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model
... protein p53 plays a critical role in cell cycle regulation, DNA repair, and ...damage, p53 activates a number of genes involved in cell cycle arrest or apoptosis, such as p21 (WAF1) and bax ... See full document
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PCR-in situ hybridization detection of human T-cell lymphotropic virus type 1 (HTLV-1) tax proviral DNA in peripheral blood lymphocytes of patients with HTLV-1-associated neurologic disease.
... contain HTLV-1 tax ...contained HTLV-1 tax DNA. When estimates of HTLV-1 proviral load in HAM/TSP PBL are performed by PCR on solution-phase samples, it is assumed ... See full document
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Characterization and Sequencing of Prototypic Human T-Lymphotropic Virus Type 1 (HTLV-1) from an HTLV-1/2 Seroindeterminate Patient
... these cell lines ...the HTLV-1 tax gene, a crucial factor for transactivation and tran- scription of other HTLV-1 genes, we performed RT-PCR for HTLV-1 ...B ... See full document
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Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.
... within HTLV-1 gp46 were isolated. The epitope recognized by HMAb PRH-1 is located between amino acids 260 and 294 of HTLV-1 ...of HTLV-1-infected cells, this antibody had ... See full document
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Oncogenic Human T-Cell Lymphotropic Virus Type 1 Tax Suppression of Primary Innate Immune Signaling Pathways
... that Tax binds to the ID domain of RIP1 to prevent down- stream NF- B-independent innate immune signaling ...whether Tax prevented RIP1 binding to required signaling partners to disrupt innateosome ... See full document
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Functional analysis of human T lymphotropic virus type 2 Tax proteins
... though Tax 1 and Tax 2 share approximately 70% homology, previous studies comparing the activities of Tax 1 and Tax 2 proteins have shown that functional dif- ... See full document
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Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein
... Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent for adult T-cell ...leukemia. HTLV-1 transforms ... See full document
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Human T-Cell Lymphotropic Virus Type 3 (HTLV-3)- and HTLV-4-Derived Antisense Transcripts Encode Proteins with Similar Tax-Inhibiting Functions but Distinct Subcellular Localization
... The HTLV-1 LTR has previously been shown to be acti- vated by Tax3 ...could inhibit Tax1- and Tax3-mediated HTLV-1 LTR and HTLV-3 LTR ...for Tax inhibition by HBZ (15). ... See full document
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Serological, Epidemiological, and Molecular Differences between Human T Cell Lymphotropic Virus Type 1 (HTLV 1) Seropositive Healthy Carriers and Persons with HTLV I Gag Indeterminate Western Blot Patterns from the Caribbean
... detect HTLV-1 proviral sequences, even by the use of highly con- served HTLV-1 and HTLV-2 primers on fresh or cultured PBMCs of those individuals presenting an HTLV ... See full document
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Distinct Transformation Tropism Exhibited by Human T Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Is the Result of Postinfection T Cell Clonal Expansion
... by HTLV-1 (12). The late activation of the CD8 ⫹ T cells and the late expression of HSPGs on their surface result in the late proviral load peak (weeks 4 to 8) in these cells compared to CD4 ⫹ ... See full document
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Tuberculosis incidence in a cohort of individuals infected with human T lymphotropic virus type 1 (HTLV 1) in Salvador, Brazil
... both HTLV-1 infected or uninfected groups) were under antiretroviral ...that HTLV-1-infected patients were more prone to develop TB as a result of these comorbidi- ...to HTLV-1 ... See full document
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Immunopathological mechanisms of human T cell lymphotropic virus type 1 (HTLV I) uveitis Detection of HTLV I infected T cells in the eye and their constitutive cytokine production
... stimuli. HTLV-I-infected TCC from the ocular lesion also constitutively produced high amounts of IL-1 alpha (12,699 pg/ml), IL-2 (61 pg/ml), IL-3 (428 pg/ml), IL-8 (1,268 pg/ml), IL-10 (28 pg/ml), ... See full document
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Prevalence and risk factors for Human T-Lymphotropic Virus Type 1 (HTLV-1) among maintenance hemodialysis patients
... Student’s t-test for independent samples; categorical variables were compared using the chi square (with con- tinuity correction) or Fischer’s exact ...with HTLV-1 seropositivity charac- terized by a ... See full document
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Analysis of Functional Conservation in the Surface and Transmembrane Glycoprotein Subunits of Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2
... the HTLV-1 and HTLV-2 SU glycopro- teins contain homologous neutralizing determinants which are type specific ...in HTLV-1), in which mutations only slightly diminished ... See full document
6
Human T-cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation mediated by vascular cell adhesion molecule-1: evidence for involvement of cell adhesion molecules in HTLV-1 biology.
... mediates HTLV-1-in- duced syncytium ...mediate HTLV-1 syncytium formation, since fusion seen in the case of transfected cells might result from factors such as overexpres- sion of the adhesion ... See full document
8
Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry
... the HTLV-1 Env to form a ternary complex. FIG. 4. NRP1 and HTLV-1 Env interact at the cell ...control cell sonicate (white peaks) or a cell sonicate containing SU-rFc ... See full document
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The Receptor Complex Associated with Human T-Cell Lymphotropic Virus Type 3 (HTLV-3) Env-Mediated Binding and Entry Is Distinct from, but Overlaps with, the Receptor Complexes of HTLV-1 and HTLV-2
... FIG. 2. HTLV-3 SU binds to CD4 ⫹ and CD8 ⫹ T cells, dendritic cells, and B ...(A) HTLV-3 SU binding to CD4 ⫹ T ...the HTLV-3 SU protein fused to rabbit IgG (HTSU3-IgG/pCMV-Env) ... See full document
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