[PDF] Top 20 Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1.
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Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1.
... After that step, LA viruses efficiently infect cells even at very low cell surface CD4 concentrations, whereas infectivity of primary isolates is strongly dependent on the level of CD4 e[r] ... See full document
8
Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.
... of human immunodeficiency virus type 1 (HIV-1) used in neutralization experiments had been adapted in the laboratory to growth in immortalized T-cell lines (TCLA ... See full document
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CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1.
... focal infectivity method to quantitatively analyze the CD4, CXCR-4, and CCR-5 dependen- cies for infections by diverse primary patient (PR) and laboratory-adapted (LA) ... See full document
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Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage
... HIV-positive patient obtained from the NIH AIDS Research and Reference Reagent ...HIV-negative human serum specimen was used in the experiments as a negative ...Two human MAbs were used in this ... See full document
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Infection of SK-N-MC cells, a CD4-negative neuroblastoma cell line, with primary human immunodeficiency virus type 1 isolates.
... at CD4-independent infection have used laboratory strains or their respective molec- ular ...whether primary human immunodeficiency virus type 1 isolates ... See full document
5
Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
... primate immunodeficiency viruses into target cells is mediated by the viral envelope glycoproteins, gp120 and gp41, which are organized into trimeric complexes on the virion surface (2, ...the primary ... See full document
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Chemokine Coreceptor Usage by Diverse Primary Isolates of Human Immunodeficiency Virus Type 1
... any primary viruses that used CCR3 as an entry ...for virus entry (3, 5, 46). The discrepancy likely represents differences in the transformed cell lines tested and the cell surface expression levels ... See full document
6
Cytopathicity of Human Immunodeficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status
... (Table 1 and ...in differences between early and late viruses within a given pa- tient or between viruses from patients with different genotypic ...such differences. Each infection yielded moderate ... See full document
6
Increased CCR5 Affinity and Reduced CCR5/CD4 Dependence of a Neurovirulent Primary Human Immunodeficiency Virus Type 1 Isolate
... in primary brain cultures was measured 28 days ...for 1 h at 37°C, washed twice with perm/wash buffer (Pharmingen), and resuspended in 400 l of 1% (wt/vol) ...HIV-1 isolates. (A) MDM ... See full document
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Genetic and Functional Diversity of Human Immunodeficiency Virus Type 1 Subtype B Nef Primary Isolates
... seven primary Nef isolates: five from a long-term nonpro- gressing human immunodeficiency virus (HIV)-infected individual and one each from two patients with ...for CD4 ... See full document
9
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
... of primary T-cell-tropic HIV-1 are directly dependent on CD4 cell surface concentra- tions, whereas laboratory-adapted T-cell-tropic viruses can ef- ficiently infect cells independently ... See full document
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Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
... their primary sequence, the corresponding recep- tors are named accordingly C-C or C-X-C ...from primary non-T-cell-line adapted (also called macrophage-tropic or M-tropic) viruses utilized CCR5 and, ... See full document
10
Antibody Binding and Neutralization of Primary and T-Cell Line-Adapted Isolates of Human Immunodeficiency Virus Type 1
... (Central Laboratory of the Netherlands Red Cross) through the NIBSC AIDS Reagent Project (Herts, United ...the virus population and reca- pitulate coreceptor use and neutralization sensitivity phenotypes ... See full document
12
Presence of Host ICAM-1 in Laboratory and Clinical Strains of Human Immunodeficiency Virus Type 1 Increases Virus Infectivity and CD4+-T-Cell Depletion in Human Lymphoid Tissue, a Major Site of Replication In Vivo
... as primary peripheral blood mononuclear cells, have clearly shown that several virion-anchored host proteins are still func- tional and may thus participate in the pathogenesis of HIV-1 ...the virus ... See full document
11
Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity
... the infectivity of HIV-1 virions by producer cell ...CypA dependence, three different competitive inhibitors of the CA- CypA interaction, and cell lines in which CypA expression was disrupted by two ... See full document
9
UPF1 Is Crucial for the Infectivity of Human Immunodeficiency Virus Type 1 Progeny Virions
... into human immunodeficiency virus type 1 (HIV-1) particles and exhibits potent antiviral activity when overexpressed in virus-producing cells ...ortholog, human ... See full document
9
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... the CD4-independent effect of Nef on HIV-1 infectivity, we made use of a previously described set of mutant HIV-1 pro- viruses that lack most or all of MA but are nevertheless able to ... See full document
6
Induction of Neutralizing Antibodies to T-Cell Line-Adapted and Primary Human Immunodeficiency Virus Type 1 Isolates with a Prime-Boost Vaccine Regimen in Chimpanzees
... heterologous primary isolates BZ167, 92HT593, and ...each virus-serum mixture for ...the virus-serum mixture with culture medium and overnight incubation, the medium was supplemented with PHA ... See full document
8
CXCR4-Dependent Infection of CD8+, but Not CD4+, Lymphocytes by a Primary Human Immunodeficiency Virus Type 1 Isolate
... Purified CD4 ⫹ and CD8 ⫹ cells, as well as CD4 ⫹ CXCR4 ⫹ MT-2 and CEM T-cell lines, were used for infection and inhibition studies (34, ...of primary CD4 ⫹ and CD8 ⫹ lympho- cytes, cells from ... See full document
9
Antibody-Mediated Neutralization of Primary Human Immunodeficiency Virus Type 1 Isolates: Investigation of the Mechanism of Inhibition
... relevant primary isolates (PI) from infected patients are much more refractory to neutralization than TCLA strains (9, 25, ...qualitative differences in the epitopes involved in the neutralization of ... See full document
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