[PDF] Top 20 Dramatic reduction of mortality in pneumococcal meningitis

... out of the 55 patients were treated with ceftriaxone (dosage 4 g intravenously per day). Three patients were treated with meropenem and vancomycin because the medical history of these patients prompted physicians to ... See full document

... pneumonia, meningitis, and bacteremia in children and adults, including the elderly, and is responsible for high rates of morbidity and mortality ...of pneumococcal meningitis in children less ... See full document

... Our study showed that PM is a disease with high mortality and neurological sequelae in pediatric patients, and complications during the clinical course occur frequently. In pediatric PM patients, age less than 28 ... See full document

... the mortality analysis, variables representing ICU admis- sion, respiratory failure, and abnormal neuroimaging studies could not be fitted in multivariate models be- cause of their essential collinearity with ... See full document

... bacterial meningitis. These studies have demonstrated a possible reduction in mortality that has, however, only been found in open studies performed in populations of patients whose clinical ... See full document

... cal meningitis for both mortality [4] and brain patho- physiology (attenuated CSF pleocytosis [2], increased cerebral perfusion pressure and mean arterial pressure as well as an interrupted cerebral ... See full document

... causing meningitis and contribute to childhood malnutrition, which was associ- ated with worse prognosis in our risk factor ...of mortality and recurrent disease in HIV-infected children with bacterial ... See full document

... develop pneumococcal meningitis, and that the disease is associ- ated with higher mortality in IL-1R −/− mice compared to wild-type ...during pneumococcal meningitis ... See full document

... with pneumococcal meningitis was assessed in a recent study ...significant reduction of mortality and reduced the extent of cortical damage, but only one com- pound combining the properties of ... See full document

... were inoculated into the cisterna magna. The time of treat- ment was selected as the latest time point at which antimi- crobial treatment could realistically lead to recovery. Treatment was initiated by dividing all ... See full document

... bacterial meningitis in infants and children is undergoing a deep ...bacterial meningitis of infants and children was to ...and Pneumococcal vaccine in October, 2012 were introduced in the national ... See full document

... increased mortality nor with degree of immunosuppression, as measured by CD4 cell count, though it should be taken into consideration that the majority of patients in both the deceased and liv- ing groups had CD4 ... See full document

... reported, meningitis in the absence of pleocytosis may ...prognosis. Mortality may be increased with dual infection, fungal infection and immunocompromised ...high mortality associated with bacterial ... See full document

... Our study shows that vascular damage is key in the process of brain damage in pneumococcal meningitis. All patients had medium-large artery inflammation, cerebral haemorrhage, and infarction. Gross changes, ... See full document

... pneumoniae meningitis, as this pathogen is the commonest cause of ABM in children in those areas with a high incidence of HIV ...for pneumococcal meningitis in ... See full document

... Our assays to determine the level of antigen detected by the antibodies under the defined conditions of this study indicate that 107 live or heat-killed pneumococci per ml, 4 ,ug of lysa[r] ... See full document

... and mortality burden have dif- fered both in magnitude and age distribution during the four pandemics that have occurred in the past century, it is difficult to characterize a “typical” ...of pneumococcal ... See full document

... community-acquired pneumococcal men- ingitis in whom autopsy was performed between 1985 and 2016 were identified from two nationwide prospec- tive cohort studies and in the neuropathology database of the Academic ... See full document

... that meningitis-induced brain injury depends on both the host inflammatory response and the direct bacterial toxicity ...The pneumococcal cell wall and pneumolysin initiate immune activation in the CSF by ... See full document

... penicillin is presented. The patient had normal nnmunity and no demonstrable sequestered focus of infection but failed to respond to appropriate doses of intravenous penicillin. Treatmen[r] ... See full document