[PDF] Top 20 Effect of Alpha Interferon on the Hepatitis C Virus Replicon
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Effect of Alpha Interferon on the Hepatitis C Virus Replicon
... Hepatitis C virus (HCV) causes persistent infection in ap- proximately 80% of infected adults and variable and severe liver disease in an estimated 70% of those who cannot clear the virus ... See full document
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Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation
... AGA C-3⬘; ISG56 (antisense), 5⬘-TCT TCT ACC ACT GGT TTC ATG C-3⬘; ISG15 (sense), 5 ⬘ -CTC TCG AGC CAT GGG CTG GGA CCT GAC GG-3 ⬘ ; ISG15 (antisense), 5⬘-GCT CTA GAT TAG CTC CGC CCG CCA GGC TCT G-3 ⬘ ; ADAR1 ... See full document
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Antiviral Effect and Virus-Host Interactions in Response to Alpha Interferon, Gamma Interferon, Poly(I)-Poly(C), Tumor Necrosis Factor Alpha, and Ribavirin in Hepatitis C Virus Subgenomic Replicons
... ditis virus (EMCV) IRES drives translation of the HCV non- structural proteins, and the construct terminates with the 3⬘ NCR of ...the replicon RNA can be ...A replicon has been developed from a ... See full document
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Modeling Subgenomic Hepatitis C Virus RNA Kinetics during Treatment with Alpha Interferon
... the replicon system and chronic HCV patients have many similarities, the slope and length of the first phase HCV RNA decline in replicon cells are slower, continu- ing ⬃ 2 to 3 days longer with 100 U/ml ... See full document
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Genetic Heterogeneity of Hypervariable Region 1 of the Hepatitis C Virus (HCV) Genome and Sensitivity of HCV to Alpha Interferon Therapy
... with virus eradication after IFN-␣ ...beneficial effect of combining ribavirin with IFN-␣ to treat HCV infection (7, 34, 47) could be due to the modulation of several immune cell functions, but the ... See full document
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Evolution of the Hepatitis C Virus Second Envelope Protein Hypervariable Region in Chronically Infected Patients Receiving Alpha Interferon Therapy
... spontaneous hepatitis C aggravation was recently estimated at only ...topathic effect of HCV has yet been ...chronic hepatitis C (reviewed in references 32 and 47), could also be ... See full document
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Inhibition of Alpha Interferon Signaling by Hepatitis B Virus
... that hepatitis C virus, a member of the Flaviviridae family, induces the upregulation of PP2Ac in vivo (liver biopsy studies of HCV transgenic mice) and in vitro (tetracycline-regulated HCV protein ... See full document
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Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype
... the virus passage ...the effect was more prominent with IFN- ␣ -resistant populations at ...the virus in ...p100 virus with a history of passages in the presence of IFN- ␣ , but it was similar ... See full document
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Effect of Retreatment with Interferon Alone or Interferon plus Ribavirin on Hepatitis C Virus Quasispecies Diversification in Nonresponder Patients with Chronic Hepatitis C
... Alpha interferon (IFN- ␣ ) treatment is effective on a long-term basis in only 15 to 25% of patients with chronic hepatitis ...the hepatitis C virus (HCV) ... See full document
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Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro
... clear effect on negative-strand HCV RNA production, was ...inhibitory effect of IFN-␣ may have been weaker in these two cultures, permitting low-level viral replication, while negative-strand HCV RNA was ... See full document
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Reduced expression of Jak 1 and Tyk 2 proteins leads to interferon resistance in Hepatitis C virus replicon
... developed interferon resistant cell lines by treating low inducer replicon cells with alpha ...after interferon treat- ...these replicon cells since the cured cells prepared from each ... See full document
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Identification of Alpha Interferon-Induced Envelope Mutations of Hepatitis C Virus In Vitro Associated with Increased Viral Fitness and Interferon Resistance
... domains of E2 was suggested to influence outcome of IFN- ␣ - based therapy in patients (7, 66). Further, regions flanking PePHD showed sequence variation in breakthrough patients (61). NS5A also was suggested to mediate ... See full document
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Bile Acids Promote the Expression of Hepatitis C Virus in Replicon-Harboring Cells
... Hepatitis C virus (HCV) is a cause of chronic liver disease, with more than 170 million persistently infected individuals ...of alpha interferon (IFN- ␣ ) and ribavirin is effective for ... See full document
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Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus
... of virus-specific memory T cells precipitates with chronic HCV ...acute hepatitis C is a cause or effect of an enhanced response to therapy re- mains ...an effect of viral ...the ... See full document
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New Antiviral Pathway That Mediates Hepatitis C Virus Replicon Interferon Sensitivity through ADAR1
... Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide and nearly 3 million in the United States ...pegylated alpha interferon (IFN- ␣ ) with ribavirin is ... See full document
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Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection
... Patients and samples. The study group consisted of 25 randomly selected patients (19 males and 6 females; mean age, 44 ⫾ 10 years; range, 26 to 63 years) with chronic dual HCV and TTV infection. All patients were free ... See full document
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Efficient Virus Assembly, but Not Infectivity, Determines the Magnitude of Hepatitis C Virus-Induced Interferon Alpha Responses of Plasmacytoid Dendritic Cells
... Jc1- and JFH1-infected hepatoma cells induce pDC to mount IFN-␣ responses. To identify viral determinants that crucially FIG 1 pDC stimulated with crude preparations of HCV strain Jc1, but not HCV strain JFH1, mount IFN- ... See full document
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Aplastic anemia associated with interferon alpha 2a in a patient with chronic hepatitis C virus infection: a case report
... with interferon (IFN)-a has also been reported to trigger autoimmune phenom- ena in up to 3% of cases, with AIHA being the most prevalent and most significant phenomena seen in clini- cal practice ... See full document
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Hepatitis C Virus Infection Impairs IRF-7 Translocation and Alpha Interferon Synthesis in Immortalized Human Hepatocytes
... As activation of the ISRE promoter in the presence of HCV has been noted, it is implied that STAT1 and STAT2 het- erodimerization occurs in the presence of IRF-9. Activation of ISRE promoters leads to an increase of ... See full document
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Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA Helicase
... a hepatitis C virus (HCV) Con1 subgenomic replicon to ascertain the role of the helicase in viral ...new replicon lacked two-thirds of the NS3 helicase ( ⌬ hel), and six others ... See full document
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