[PDF] Top 20 Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice
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Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice
... ICR mice aged four weeks were obtained from Japan SLC, ...four mice were housed in each cage under controlled conditions of temperature and ...light. Mice in hyperthyroid group (n = 7) were ... See full document
6
Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells
... papillary thyroid carcinomas ...a sodium/iodine symporter (NIS), and subsequent radioiodide-refractory (RAI) metastatic ...restore NIS expression and Iodide uptake by ... See full document
6
HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells
... Background: Sodium/iodide symporter (NIS)-mediated iodide uptake plays an important physiological role in regulating thyroid gland function, as well as in diagnosing and treating ... See full document
15
Codon-optimized Human Sodium Iodide Symporter (opt-hNIS) as a Sensitive Reporter and Efficient Therapeutic Gene
... the thyroid, stomach, and urinary ...cell-specific NIS expression, and did not find any sig- nificant injury or adverse effects on cardiac function, suggesting that exogenous NIS is safe in ... See full document
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Klutz, Kathrin (2010): Molecularly targeted imaging and radionuclide therapy of non-thyroidal tumors following viral and non-viral sodium iodide symporter (NIS) gene delivery. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... viral gene expression ...targeted gene delivery, as they can be produced in high titers (10 10 to 10 11 infectious units per ml), they can infect nondividing cells, and gene expression ... See full document
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Schug, Christina (2018): Advanced mesenchymal stem cell-mediated gene delivery of the theranostic sodium iodide symporter (NIS) in non-thyroidal tumors. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... reporter gene NIS, to invade experimental ...inflamed tissues, utilizing a cascade of events driven by cytokines, chemokines, integrins and ... See full document
139
Overcoming the lack of expression of the sodium iodide symporter protein in anaplastic thyroid cancer stem cells by targeting the phosphatidyl inositol 3 kinase signaling pathway
... est sodium-iodide symporter (NIS) ...for iodide accumulation in ...two sodium molecules along with one iodide molecule from the bloodstream into these cells to facilitate ... See full document
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Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas
... of NIS protein, well-differ- entiated thyroid carcinoma does not accumulate radioiodine to the same extent as normal thyroid tissue in vivo, suggesting that NIS is inactive in patients with ... See full document
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Sodium Iodide Symporter for Nuclear Molecular Imaging and Gene Therapy: From Bedside to Bench and Back
... the thyroid peroxidase gene was intro- duced, however, results were conflicting and not very effective ...thyroglobulin gene was also suggested to increase retention time ...the thyroid gland ... See full document
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Urnauer, Sarah (2017): Improved synthetic gene delivery vehicles for advanced bioimaging-guided tumor-targeted application of the sodium iodide symporter (NIS) as theranostic gene. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... differentiated thyroid cancer using the ionizing radiation of 131 I to induce toxic effects in cancer cells represents an efficient strategy with high response rates, which are mirrored by the low mortality of ... See full document
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Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer.
... of gene expression – measured by GFP imaging and radioiodide uptake assay (Fig ...of iodide in any organs other than perhaps the thyroid, which as previously mentioned has not caused adverse ... See full document
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Original Article Identification of risk factors for thyroid cancer in Urumqi, China
... (BRAF) gene are caused and the transcrip- tion and expression of NIS are suppressed, resulting in further impairment of thyroid iodine intake capacity and thyroid cancer ...roid ... See full document
7
Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus
... reporter gene chosen for insertion into GLV- 1h153 was based on the already successful PET and SPECT imaging characteristics of the human sodium iodide symporter (hNIS) and carrier-free ... See full document
14
Conserved charged amino acid residues in the extracellular region of sodium/iodide symporter are critical for iodide transport activity
... of NIS homologs. Amino acid sequences of NIS from mouse, rat, and pig were aligned with those of human by ClustalW ...all NIS homologs are indicated by ...human NIS. Amino acid sequences of ... See full document
9
A novel oncolytic viral therapy and imaging technique for gastric cancer using a genetically engineered vaccinia virus carrying the human sodium iodide symporter
... All animal experiments were performed under approved protocols and in accordance with ethical guidelines of the Institutional Animal Care and Use Committee (IACUC) at Memorial Sloan-Kettering Cancer Center (MSKCC). ... See full document
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Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism
... normal-sized thyroid gland, suggesting that dyshormonogenic etiologies may be more important than previously anticipated ...(2). Thyroid hormonogenesis requires sufficient iodide substrate, in ... See full document
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Immunotoxic Effect of Sodium Fluoride and the Mitigating Effect of Selenium and Curcumin in Male Mice
... the expression of adhesion molecules by endothelial cells, TNF is selectively cytotoxic for some transformed cell lines and can exert cytotoxic effects against certain solid ... See full document
7
Hypoxia-targeted 131 I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery
... of NIS as a theranostic gene [13, 28– ...as gene delivery vehicles for NIS under the control of the constitutively active cytomegalovirus (CMV) ...Using NIS both as reporter and therapy ... See full document
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Original Article Improved radioiodine-131 imaging of prostatic carcinoma using the sodium iodide symporter gene under control of the survivin promoter
... tumor-specific gene expression for tumor-tar- geted gene imaging and therapy ...the NIS gene driven by the survivin promoter (Ad-Sur-NIS) in liver cancer cells and ... See full document
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IODINE CONTAINING COMPOUNDS OF EXTRATHYROIDAL TISSUES
... labeled diet of known total iodine content is described for the quantitative estimation of total iodine and iodine-containing compounds in body tissues, plasma, and excreta of the rat.. [r] ... See full document
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