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[PDF] Top 20 Effects of cellular origin on differentiation of human induced pluripotent stem cell–derived endothelial cells

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Effects of cellular origin on differentiation of human induced pluripotent stem cell–derived endothelial cells

Effects of cellular origin on differentiation of human induced pluripotent stem cell–derived endothelial cells

... EC differentiation efficiency, we assumed EC-iPSCs might retain EC marker gene expression in ...donor cellderived iPSCs before and after differentiation, using fetal primary ECs as a ... See full document

13

Differentiation of primordial germ cells from premature ovarian insufficiency-derived induced pluripotent stem cells

Differentiation of primordial germ cells from premature ovarian insufficiency-derived induced pluripotent stem cells

... that human iPSCs can differentiate into ...the induced differenti- ation of PGCs from iPSCs in ...induction differentiation from iPSCs in ...the cell level, it is a disorder of oocyte ... See full document

11

Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury

Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury

... Mesenchymal stem cells (MSC) are special cells with multi-lineage differentiation abilities ...for cell-based medical therapies because of their multi-lineage differentiation ... See full document

15

Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

... the differentiation and development of many cell ...extra cellular matrix, stabilization of the contractile structure due to increase in myofibril length, and lateral coupling of multiple myofibrils ... See full document

17

Establishment of porcine and human expanded potential stem cells

Establishment of porcine and human expanded potential stem cells

... recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their differentiation 1 ...germ ... See full document

56

Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

... with cells of the neurovascular unit (NVU), maintain CNS homeostasis ...Primary cell culture of animal and human BMECs has been employed (30–33); however, after removing BMECs from the brain ... See full document

12

Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis

Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis

... Stem cells are known to have the ability to promote ...of stem cells can enhance the growth and invasion of vessels from surrounding tissues by promoting tube formation by endothelial ... See full document

13

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis

... of cell – material interactions and the resulting effects following implantation of these combined ...combined effects of iPSC-ECs and their engraftment platforms will more readily lead to the ... See full document

15

Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells

Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells

... Induced pluripotent stem cell maintenance and differ- entiation procedures are rapidly evolving towards fully defined compositions ...BBB differentiation [30], with no discernible ... See full document

13

3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders

3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders

... ZIKV induced cell death in neuroepithelial progenitors, attenuated the proliferation of progenitor cells, and increased the size of lumen within ventricular ...ZIKV-infected human fetal brain ... See full document

12

Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells

Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells

... singularized- cell seeding approach reported here allowed H9-gener- ated BMECs to achieve high TEER using the standard 2-day EC media ...new stem cell lines, centered around 30,000 cells/cm 2 ... See full document

12

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

... appendage- derived MSCs are an attractive source of transplantable stem cells for wound repair because they have no risk to donors, easy accessibility, and a low incidence of graft- versus-host ... See full document

18

Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

... mesoderm differentiation, cardiac progenitor cell for- mation, and cardiac ...of pluripotent stem cell-derived CMs mimic the cardiomyogenic lineage commitment in ...cardiac ... See full document

20

Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes

Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes

... While conventional methods such as the manual patch clamp provide detailed information of the electrical activity of cardiomyocytes, the complexity of such tech- nique necessitates the professional training of the elec- ... See full document

7

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

... potential cell source of ...with cell fate. Cell lineage identity is necessary for homeostasis of most adult tissue and even subtle shifts in cell identity can severely impact tissues as they ... See full document

13

Modulating the biochemical and biophysical culture environment to enhance osteogenic differentiation and maturation of human pluripotent stem cell-derived mesenchymal progenitors

Modulating the biochemical and biophysical culture environment to enhance osteogenic differentiation and maturation of human pluripotent stem cell-derived mesenchymal progenitors

... designing stem cell culture environments in micro-bioreactor formats) ...cultured cells and tissues, allowing high-throughput studies with increased numbers of ex- perimental conditions and ... See full document

11

Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions

Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions

... assess cell migration, in vitro wound closing assays were performed over a period of 24 ...different endothelial phenotypes of hESC origin still needs to be ...hESC- derived ECs, we used ... See full document

17

Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells

Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells

... the differentiation of functional eNOS competent endothe- lial cells from human ...biological effects, including cell differentiation, survival, and angiogenesis ...Platelet ... See full document

10

Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector

Robust and highly efficient hiPSC generation from patient non-mobilized peripheral blood-derived CD34+ cells using the auto-erasable Sendai virus vector

... lines, derived from 15 patients affected by 8 different diseases, which in- cluded autoimmune diseases such as SLE and PD, im- mune deficiencies exemplified by X-CGD, and other diseases such as MD and KCS2 (Table ... See full document

16

Electrospinning of poly (ester amide) fibres for mesenchymal progenitor cell differentiation

Electrospinning of poly (ester amide) fibres for mesenchymal progenitor cell differentiation

... In 2001, this research group began to use autologous bone marrow mononuclear cells (BM- MNC) from the anterior superior spine, which were available on the day of surgery. TEVGs were implanted in 25 pediatric ... See full document

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