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[PDF] Top 20 Engineering microbial chemical factories using metabolic models

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Engineering microbial chemical factories using metabolic models

Engineering microbial chemical factories using metabolic models

... Metabolic engineering has been used for the analysis, design, and optimization of metabolic pathways with sig- nificant successes [13, 14, ...cussed metabolic engineering tools ... See full document

11

Engineering redox homeostasis to develop efficient alcohol-producing microbial cell factories

Engineering redox homeostasis to develop efficient alcohol-producing microbial cell factories

... systems metabolic engineering still await more exciting developments for controlling the metabolic fluxes and energy/redox requirements in the context of maximiz- ing product titer, yield and ... See full document

11

Development of bio-based fine chemical
            production through synthetic bioengineering

Development of bio-based fine chemical production through synthetic bioengineering

... controlling metabolic pathways to supply the optimal sub- strate ...productive microbial fer- mentation systems for producing fine chemicals, the genes encoding the required enzymes are introduced into an ... See full document

19

Development of Computational Tools for Metabolic Engineering

Development of Computational Tools for Metabolic Engineering

... ABSTRACT: Metabolic engineering involves construction and optimization of biosynthetic pathways to maximize yields of desired products for various biochemical ...fundamental engineering principles in ... See full document

10

Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production

Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production

... cerevisiae using the GAL promoter also increased the metabolic flux ...the metabolic flux from IPP to ergosterol, which in turn pushed the conversion of IPP toward artemisinic acid ... See full document

9

In silico characterization of microbial electrosynthesis for metabolic engineering of biochemicals

In silico characterization of microbial electrosynthesis for metabolic engineering of biochemicals

... as microbial electrosynthesis or bioelectrosynth- esis ...bioelectro- chemical systems where electron transfer has occurred between the cell membrane and the cathode ...central metabolic pathways of ... See full document

14

Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas

Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas

... The continued use of fossil fuels is no longer tenable. A finite resource, their extraction, processing and exploita- tion is wreaking havoc with the environment through pollution and global warming. The challenge facing ... See full document

8

Metabolic engineering of microbial cell factories for production of nutraceuticals

Metabolic engineering of microbial cell factories for production of nutraceuticals

... in DXP pathway resulted in 433 mg/L of astaxanthin (equivalent to 7.12 mg/g DCW) with a high productiv- ity (9.62 mg/L/h) in glycerol fed-batch fermentation [68]. Despite the use of an industrially-limiting inducer, ... See full document

11

Metabolic engineering of microorganisms for production of aromatic compounds

Metabolic engineering of microorganisms for production of aromatic compounds

... platform chemical used in food, pharma- ceutical and polymer ...acid) using tannese ...on microbial production of pyro- ...respectively. Using this engineered ... See full document

29

Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering

Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering

... sugar-derived chemical building blocks by the ...and chemical industries ...and chemical synthesis [4]. Of those, microbial fermentation is the more cost-effective approach owing to the low ... See full document

11

Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine

Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine

... The stabilizing and function-preserving effects of ectoines have spurred considerable interests in these compounds and have led to the development of a variety of practical applications [7,13,14]. As a consequence, ... See full document

16

A Survey of the Usage of Personal Protective Devices in Industrial Workers in Yazd, Iran, in 2011

A Survey of the Usage of Personal Protective Devices in Industrial Workers in Yazd, Iran, in 2011

... Data were analyzed by SPSS for Windows (version 19, SPSS Inc., Chicago, IL, USA) using chi-square test. The level of significance was set at P < 0.050. An informed consent was obtained from all subjects. This ... See full document

7

Identification and physiological characterization of phosphatidic acid phosphatase enzymes involved in triacylglycerol biosynthesis in Streptomyces coelicolor

Identification and physiological characterization of phosphatidic acid phosphatase enzymes involved in triacylglycerol biosynthesis in Streptomyces coelicolor

... were grown to mid-log phase and then cultivated for 16 h at 23 C after induction with L-arabinose. Immunoblot ana- lysis of the corresponding E. coli soluble homogenates showed that each His-tagged protein migrated ... See full document

12

Comparison of microbial communities from different Jinhua ham factories

Comparison of microbial communities from different Jinhua ham factories

... the microbial diversity and community structure markedly changed in different aged workshops which corresponded to the strong flavoring characteris- tics of Jinhua ... See full document

8

Microbial Metabolic Networks at the Mucus Layer Lead to Diet Independent Butyrate and Vitamin B12 Production by Intestinal Symbionts

Microbial Metabolic Networks at the Mucus Layer Lead to Diet Independent Butyrate and Vitamin B12 Production by Intestinal Symbionts

... and metabolic stimulation, further emphasizes the importance of having the right bacteria at the right ...beneficial metabolic gene regulation in human cell types (36, ...other microbial species ... See full document

14

Enhanced heterologous protein productivity by genome reduction in Lactococcus lactis NZ9000

Enhanced heterologous protein productivity by genome reduction in Lactococcus lactis NZ9000

... deleted using the Cre-loxP deletion system as the first steps toward a minimized genome in this ...as microbial cell factories for heterologous protein production (intracellular and secretory ... See full document

13

Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design

Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design

... GEM crossm Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Insti[r] ... See full document

6

Yeast cell factories for fine chemical and API production

Yeast cell factories for fine chemical and API production

... Yeast alcohol oxidases were shown to be responsible for the oxidation of methanol and other primary alcohols [83-85]. However, they did not oxidize secondary alcohols. In general, reports on oxidation reactions performed ... See full document

36

A class of dynamic models describing microbial flocculant with nutrient competition and metabolic products in wastewater treatment

A class of dynamic models describing microbial flocculant with nutrient competition and metabolic products in wastewater treatment

... In the research of microbial flocculants, flocculant-producing bacteria have received ex- tensive attention. As early as 1935, Butterfield successfully isolated flocculant-producing bacteria from activated sludge. ... See full document

14

Use of titanium dioxide nanoparticles biosynthesized by Bacillus mycoides in quantum dot sensitized solar cells

Use of titanium dioxide nanoparticles biosynthesized by Bacillus mycoides in quantum dot sensitized solar cells

... As shown in Figure 5a, almost no toxicity was deter- mined in chemical and biological nanoparticles. E. coli cultures were able to reestablish their growth after NPs exposure. To confirm our results, growth ... See full document

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