[PDF] Top 20 Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
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Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... to enhanced antiviral function in vitro, CD8 T cells from high Gag responders displayed an overall more polyfunctional cytokine profile upon stimulation with HIV peptide pools, with ... See full document
10
Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells
... which Gag-specific CD8 ⫹ T-cell activity, measured by an IFN- ␥ ELISPOT assay, was shown to be associated with a low viral set point (15, 20, 37) and also corroborate a ... See full document
15
Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection
... in CD8 ⴙ T-cell responses between tissues, patient groups, and cell ...tional T-cell subsets, we performed statistical analysis using a multivariate, correlated-errors ... See full document
12
Differential Impact of Magnitude, Polyfunctional Capacity, and Specificity of HIV-Specific CD8+ T Cell Responses on HIV Set Point
... best functional control, such as perforin expression, recently high- FIG 2 Sensitivity and specificity of Gag- and Nef-specific CD8 ⫹ T cell measurements at 6 months ... See full document
6
HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function
... ⫹ T cell frequen- cies between individuals with controlled versus progressive dis- ease, we were interested in whether there is a causative link ...⫹ T cells in HIV-1-infected subjects. (A and ... See full document
9
Vaccination with a Fusion Protein That Introduces HIV-1 Gag Antigen into a Multitrimer CD40L Construct Results in Enhanced CD8+ T Cell Responses and Protection from Viral Challenge by Vaccinia-Gag
... duced CD8 ⴙ T cell ...(SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrimer protein ...for Gag antigen alone (pGag), DNA vaccination ... See full document
10
Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
... antigen-specific T cells by providing them with the first boost of apoptotic ...apoptotic anti- gen-specific T cell responses would represent an epiphe- nomenon of the ... See full document
12
PD1 based DNA vaccine amplifies HIV 1 GAG specific CD8+ T cells in mice
... with HIV-1 GAG p24 ...of GAG-specific, broadly reactive, polyfunctional, long-lived, and cytotoxic CD8 + T cells and robust anti-GAG antibody ...vaccinia GAG ... See full document
15
High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
... and functional avidity ...(11). Functional avidity was determined as described previously ...if cell avail- ability ...background. Functional avidity was calculated by sigmoidal dose ... See full document
12
Induction of Human Immunodeficiency Virus (HIV)-Specific CD8 T-Cell Responses by Listeria monocytogenes and a Hyperattenuated Listeria Strain Engineered To Express HIV Antigens
... of cell-mediated immunity may be essential for an effective AIDS ...elicit T-cell immunity to human immunodeficiency virus (HIV) because it specifically infects monocytes, key ... See full document
7
Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome
... HLA-B*57-restricted Gag epitope TW10, which was previously associated with control of HIV-1 viremia ...54,462 HIV RNA copies/ml) of the HLA-B*57-TW10 CD8 T cell response ... See full document
9
Identification of new HIV 1 Gag specific cytotoxic T lymphocyte responses in BALB/c mice
... blood cell lysis, cells were resuspended in RPMI 1640 supplemented with 10% FBS (Gibco) and immediately used for the analysis of antigen-specific cellular immune responses by cytotoxic- ity or ... See full document
7
HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses
... aviremic HIV- infected individuals remained at higher risk of developing TB than HIV-uninfected in- dividuals, we hypothesized that progression from LTBI to pulmonary TB (PTB) might be due not only to CD4 ... See full document
18
Epitope Mapping of HIV-Specific CD8+ T Cell Responses by Multiple Immunological Readouts Reveals Distinct Specificities Defined by Function
... antiviral CD8 ⫹ T cell responses, expanding our under- standing of protective ...acute CD8 ⫹ T cell responses to smallpox and yellow fever virus vaccinations, ... See full document
12
Magnitude of Functional CD8+ T-Cell Responses to the Gag Protein of Human Immunodeficiency Virus Type 1 Correlates Inversely with Viral Load in Plasma
... the Gag and Pol precursor proteins, respectively ...the HIV-1-specific im- mune ...ELISPOT responses were observed. The breadth of the total HIV-1-specific responses for ... See full document
8
DNA Priming Increases Frequency of T-Cell Responses to a Vesicular Stomatitis Virus HIV Vaccine with Specific Enhancement of CD8+ T-Cell Responses by Interleukin-12 Plasmid DNA
... from Gag, Pol, Env, Nef, and Vif (Bio-Synthesis) at 1 g/ml as previously described (26, ...and anti-CD28/anti-CD49d (each at 1 g/ml; BD ...dead cell stain (Invitrogen) and then fixed, ... See full document
14
HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... ⫹ T cell targeting be- tween our patient groups, we also considered the influence of HLA DRB1 haplotypes, which have been reported to influence clinical outcome ...while CD8 peptides are typically ... See full document
13
Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8+ T-Cell Antiviral Activity and Correlates with Preservation of the CD4+ T-Cell Compartment
... and anti- CD49d antibodies, 1 g/ml; BD Biosciences), monensin (Golgistop, ...of anti-CD107A-fluorescein isothiocyanate (FITC) and anti-CD107B-FITC antibodies (BD Biosci- ences) was added to one of ... See full document
18
Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers
... of T-cell responses in mucosa and ...cific CD8 ⫹ T-cell responses in rectal mucosa and peripheral blood, suggesting broad dissemination of HIV-specific ... See full document
12
Weak anti HIV CD8+ T cell effector activity in HIV primary infection
... positive responses in 84% of subjects with chronic ...elicited responses in only 46% of chroni- cally infected ...elicited responses in 36% of chronically infected sub- ...to HIV peptides ... See full document
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