[PDF] Top 20 Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds
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Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds
... coreceptor binding sites of HIV-1 from subtypes A, B, C, D, F, G, and H and circulating recombinant form (CRF) 01, CRF02, and CRF11 elicit high titers of CD4i Abs during natural human infection and ... See full document
11
An Envelope Modification That Renders a Primary, Neutralization-Resistant Clade B Human Immunodeficiency Virus Type 1 Isolate Highly Susceptible to Neutralization by Sera from Other Clades
... the virus susceptibility to neutralization by polyclonal sera collected from patients in- fected with clade B viruses (Table ...to neutralization by sera collected from pa- tients infected with ... See full document
6
Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera.
... recognize epitopes within the V3 and C4 regions, respec- tively. Murine MAb 50.1 (1 mg/ml) was raised against a synthetic peptide derived from the V3 loop of HIV-1 MN and was purchased from Repligen ... See full document
10
Comparative Immunogenicity of Subtype A Human Immunodeficiency Virus Type 1 Envelope Exhibiting Differential Exposure of Conserved Neutralization Epitopes
... sub- type A HIV-1 Envs, with very different neutralization pheno- types to directly address (i) whether HIV-1 Env variants that expose conserved neutralization epitopes can lead ... See full document
12
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.
... g/ml. Neutralization at the 90% level by MAb and CD4-IgG2 concentrations of # 10 m g/ml was less common but was observed in a significant number of cases (Table ...of neutralization shown by 2F5 and ... See full document
9
CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization
... Human immunodeficiency virus type 1 (HIV-1) entry into target cells involves sequential binding of the gp120 exterior envelope glycoprotein to CD4 and to specific ... See full document
10
Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein
... A CD4-independent version of the X4 human immunodeficiency virus type 1 (HIV-1) HXBc2 envelope (Env) protein, termed 8x, mediates infection of CD4-negative, ... See full document
10
Evidence for Similar Recognition of the Conserved Neutralization Epitopes of Human Immunodeficiency Virus Type 1 Envelope gp120 in Humans and Macaques
... several neutralization targets on envelope gp120, among which are the CD4 binding site (CD4BS) (7, 23, 45); the variable V1, V2, and V3 loops; a gp120 structure that is near the chemokine recep- tor ... See full document
10
Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... with CD4 or CCR5, as described in Materials and ...that CD4 was incorpo- rated into virions at much higher levels than CCR5 (data not ...to CD4, to incorporate into MLV particles was reported ... See full document
11
Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds
... the binding of a CD4mc to one Env protomer might expose neutralizing epitopes on adjacent protomers, we tested the ability of the CH23 anti- body to inhibit the infection of Cf2Th-CCR5 cells by viruses with ... See full document
20
Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex.
... the CD4-IgG2 molecule, because although it is not a MAb, it has many properties of one [2, ...MAb-env binding curves for four MAbs shown in ...saturation binding to the monomer was achieved with all ... See full document
7
Enhanced Binding of Antibodies to Neutralization Epitopes following Thermal and Chemical Inactivation of Human Immunodeficiency Virus Type 1
... ization epitopes on viral envelope following treatment with ...of binding to gp120 MAb IgG1b12, as measured by p24 assay of virions after precipitation with ...that binding of gp120 to some of these ... See full document
8
Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate
... the neutralization of DH012 and DH012mu, the V3 peptide DP283 was used in an enzyme- linked immunosorbent assay (ELISA) to measure the bind- ing between the peptide and the antibodies in chimpanzee and guinea pig ... See full document
5
V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.
... occurring isolate may be independent of V3, the marked homogeneity of V3 se- quences among many macrophage-tropic viruses suggests that factors other than macrophage tropism per se may have played a role in their ... See full document
7
Stoichiometry of Antibody Neutralization of Human Immunodeficiency Virus Type 1
... ⫽ 1 neutralization stoichiometry is shared by all nine mono- clonal antibodies studied in this report; these antibodies ex- hibit a range of neutralization potencies and bind distinct el- ements on ... See full document
10
Simian Immunodeficiency Virus Engrafted with Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Epitopes: Replication, Neutralization, and Survey of HIV-1-Positive Plasma
... Larger sample sizes will be required to confirm the absence of such activity from HIV-positive cohorts or, if such specific- ities do arise, to more accurately determine prevalence among HIV-positive individuals. The ... See full document
12
Induction of Antibodies in Guinea Pigs and Rhesus Monkeys against the Human Immunodeficiency Virus Type 1 Envelope: Neutralization of Nonpathogenic and Pathogenic Primary Isolate Simian/Human Immunodeficiency Virus Strains
... HIV neutralization assays. Neutralization activity of guinea pig sera was mea- sured in the MT-2 cell-killing assay (25) with ...in neutralization were prepared in human peripheral blood ... See full document
10
Coreceptor Utilization by Human Immunodeficiency Virus Type 1 Is Not a Primary Determinant of Neutralization Sensitivity
... pro- virus (28) contains a BglII-BglII deletion within the envelope gene and a substitution of the viral nef gene with a cDNA encoding the murine ...simian virus 40 ori was subsequently introduced into the ... See full document
5
Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization.
... The parental MT-CSF infected only PM-1 cells and was markedly resistant to neutralization by sera from HIV-1-infected individuals, rabbit antiserum to recombinant MT-CSF gpl20, and anti-[r] ... See full document
8
Human Immunodeficiency Virus Type 1 Spinoculation Enhances Infection through Virus Binding
... significantly enhanced by spinoculation but that subsequent progression to cDNA accumulation is not further augmented ...sedimentation. Virus-containing supernatants of 100 l were therefore incubated at ... See full document
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