[PDF] Top 20 An epigenetic clock for gestational age at birth based on blood methylation data
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An epigenetic clock for gestational age at birth based on blood methylation data
... To train the DNAm GA predictor, six independent cohorts were selected to sample a wide range of GAs and ances- tries. Consistent with the approach described by Horvath [13], elastic net regression was used to select a ... See full document
11
Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth
... lower birth weight ...at birth [21]. Another recent study, which used the DNAm age predictors of Horvath and Hannum on cord blood methylation data, also con- cluded that prenatal ... See full document
14
DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936
... of methylation at one CpG methylation site (cg18314882 on chromosome 8 in the MAF1 gene) dif- fered between people who were physically frail and those who were not ...the blood, brain, omentum; see ... See full document
8
Novel regional age associated DNA methylation changes within human common disease associated loci
... novel epigenetic changes that were more likely to be functional and, due to their co-location, would enable direct integra- tion into future locus-specific common disease investiga- ...As age impacts on the ... See full document
14
Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy
... minutes. Data processing was carried out in triplicate using the median methylation level at specific CpG ...Raw data obtained from MassArray EpiTYP- ING were cleaned systematically using an R-script ... See full document
12
Elevated diastolic blood pressure until mid gestation is associated with preeclampsia and small for gestational age birth: a population based register study
... gave birth to a singleton from 2008 to 2014 in Stockholm or Gotland counties ...this data, and therefore only primiparous women were ...or blood pressure medication at the first antenatal visit, ... See full document
8
Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood
... and gestational age <34 weeks, we used DNA methylation assays from 476 venous umbilical cord blood samples and a subset of 235 who additionally had peripheral blood samples available ... See full document
12
Systematic underestimation of the epigenetic clock and age acceleration in older subjects
... DNA methylation (DNAm) age was assessed for all sam- ples of the London and Mt Sinai datasets on the R statis- tical environment (R Development Core Team, 2015) using the script provided by Horvath [8] as ... See full document
10
Racial differences in IGF1 methylation and birth weight
... following: gestational age (based on clinical estimate and the date of last menstrual period), infant birth weight, infant gender, pregnancy complications, vitamin use, presence of ... See full document
7
Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics
... This epigenetic clock for GA at delivery uses 96 CpG sites to predict GA from cord blood ...was based on LMP or ultrasound but as updating GA based on ultrasound was not common practice ... See full document
9
Epigenetic signatures of gestational diabetes mellitus on cord blood methylation
... reduces epigenetic effects due to adverse intra- uterine ...to epigenetic effects of insulin itself or, more likely, to a more severe phenotype in women requiring insulin ...whereas gestational ... See full document
11
The epigenetic clock and objectively measured sedentary and walking behavior in older adults: the Lothian Birth Cohort 1936
... these blood-based measures of epigenetic age ...immune blood cell types changes with age [12, 13]. These two epigenetic age measures were originally designed to ... See full document
6
Failure to Diagnose Congenital Heart Disease in Infancy
... 1981 through 1989, a population-based study of con- genital heart disease in Maryland, the District of Columbia, and northern Virginia enrolled 4390 cases of CCVMs. This study offers a unique opportunity to ... See full document
7
A Treatment Profile of Neonatal Hyper-Bilirubinemia in a Tertiary Health Care Hospital
... The data collected for the study includes gestational age, gender, birth weight, birth order, mode of delivery, peak serum bilirubin level and the treatment ...the blood sample ... See full document
5
Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?
... DNA methylation status can be induced: (1) ROS gener- ated by air pollution-induced oxidative stress can react with DNA, resulting into different DNA lesions, including base modifications, strand breaks, and ... See full document
14
Impact of managed clinical networks on neonatal care in England : a population based study
... of birth could have been delayed more commonly in epoch one than in epoch two, an effect that again would lead to overestimation of the impact of ...“multiple birth sets separated by transfer” the ... See full document
16
Birth weight centiles by gestational age for twins born in south India
... was based on labour room records and med- ical records maintained by the Department of Obstetrics and Gynaecology at the Christian Medical College, Vel- ... See full document
6
Gestational Age and Risk of Venous Thromboembolism From Birth Through Young Adulthood
... paternal age was also examined but not retained in the fi nal model because of its collinearity with maternal age); maternal marital status (married/ cohabiting, never married, divorced/ widowed), maternal ... See full document
10
Epigenetic supersimilarity of monozygotic twin pairs
... DNA methylation data at the CpG probe level were obtained. These data sets are publicly available ...Since methylation was measured in peripheral blood DNA, cell type compos- ition ... See full document
20
DNA methylation patterns associated with oxidative stress in an ageing population
... per methylation probe in each round of ...genotype data (10,000 permuta- ...GWAS data from the CARDIoGRAM consortium for CHD [20] and the DIAGRAM consortium for T2D ... See full document
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