[PDF] Top 20 Essential Role of Cyclization Sequences in Flavivirus RNA Replication
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Essential Role of Cyclization Sequences in Flavivirus RNA Replication
... possible role in RNA replication for interactions between conserved complementary (cyclization) se- quences in the 5 ⴕ - and 3 ⴕ -terminal regions of Flavivirus RNA was ... See full document
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The 5′ and 3′ Downstream AUG Region Elements Are Required for Mosquito-Borne Flavivirus RNA Replication
... 11-kb-long RNA ge- nome of positive polarity (see reference 10). The viral RNA encodes one open reading frame (ORF), and the resulting polyprotein is cleaved co- and posttranslationally into 3 struc- tural ... See full document
6
Regulation of RNA Synthesis by the Genomic Termini of Vesicular Stomatitis Virus: Identification of Distinct Sequences Essential for Transcription but Not Replication
... The RNA-dependent RNA polymerase of vesicular stomatitis virus (VSV), a nonsegmented negative-strand RNA virus, directs two discrete RNA synthetic processes, transcription and ...contain ... See full document
10
The Host Factor AUF1 p45 Supports Flavivirus Propagation by Triggering the RNA Switch Required for Viral Genome Cyclization
... most RNA viruses encode only a small number of proteins; accordingly, viral replication often requires the additional activity of cellular ...Several RNA-binding proteins (RBPs) have been implicated ... See full document
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Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly
... not essential for genotype 2 RNA replication, which is in contrast to what was found with genotype 1 replicons (10, ...11). Replication of mutants SL-IIz ⬘ - 56-59, SL-IIz ⬘ -78-82, and SL-IIz ... See full document
7
Fine Mapping of a cis-Acting Sequence Element in Yellow Fever Virus RNA That Is Required for RNA Replication and Cyclization
... in RNA viruses. A number of RNA viruses, both plus and minus stranded, have been shown to have genomic RNAs that cyclize or that may potentially ...to flavivirus cyclization, is that of ... See full document
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Translation of the Flavivirus Kunjin NS3 Gene in cis but Not Its RNA Sequence or Secondary Structure Is Essential for Efficient RNA Packaging
... in RNA packaging is determined by the secondary RNA structure of the NS3 gene or by the essential role of the translated NS3 gene ...stable RNA structures in the NS3 coding region of ... See full document
10
Inhibition of Flavivirus Infections by Antisense Oligomers Specifically Suppressing Viral Translation and RNA Replication
... is essential for WN viral RNA synthesis (25). (ii) The flavivirus-conserved pentanucleotide in the 3 ⬘ stem-loop of the genome ...for RNA synthesis ...that RNA elements within the ... See full document
11
Overlapping Local and Long-Range RNA-RNA Interactions Modulate Dengue Virus Genome Cyclization and Replication
... local RNA elements at each end of the ...these RNA sequences disassembles the hairpin and dumbbell ...functional RNA structures is a common fea- ture in the flavivirus ...are ... See full document
8
Specific Binding of Tombusvirus Replication Protein p33 to an Internal Replication Element in the Viral RNA Is Essential for Replication
... the essential role of the C · C mismatch for specific interaction with p33 comes from in vivo studies that demonstrated the lack of replication of DI-72 RNA in yeast and the TBSV gRNA in ... See full document
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AUF1 p45 Promotes West Nile Virus Replication by an RNA Chaperone Activity That Supports Cyclization of the Viral Genome
... The flavivirus genome is a long, dynamic RNA molecule that adopts different functional conformations during the course of the viral life ...viral RNA replication process, the initiation of ... See full document
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The Topology of Bulges in the Long Stem of the Flavivirus 3′ Stem-Loop Is a Major Determinant of RNA Replication Competence
... the replication phenotypes of resultant WN vi- ruses. A mutant WN virus RNA containing a substitution of the WN 3 ⬘ SL nucleotide sequence by the DEN2 3 ⬘ SL nucleo- tide sequence failed to initiate ... See full document
16
Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication
... Sequence and structure of BocaSR. Previous studies revealed a remarkable feature of the 3= NCR of primate bocaparvoviruses: those of HBoV1, HBoV2, and HBoV3 fold into almost identical secondary structures (45, 46). This ... See full document
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Tertiary Structural and Functional Analyses of a Viroid RNA Motif by Isostericity Matrix and Mutagenesis Reveal Its Essential Role in Replication
... the inoculated protoplasts is due to defects in nuclear import, we injected fluorescently labeled plus-strand in vitro tran- scripts into the cytoplasm of leaf cells. Both single mutants, like the wild type, appeared in ... See full document
16
Novel cis-Acting Element within the Capsid-Coding Region Enhances Flavivirus Viral-RNA Replication by Regulating Genome Cyclization
... primary sequences of the stem 2-loop 3 hairpin are not conserved among flaviviruses, sug- gesting that the secondary structure is crucial in determining the function of the stem 2-loop 3 ...their ... See full document
15
trans-Complementation Analysis of the Flavivirus Kunjin ns5 Gene Reveals an Essential Role for Translation of Its N-Terminal Half in RNA Replication
... FIG. 1. KUN ns5 deletion mutants. (A) Fragments of pBS-based intermedi- ate plasmids representing ns5 and 3⬘UTR regions. ns5His3⬘ represents part of the pBSns5His3⬘UTR sequence that codes for KUN NS5 comprising 905 amino ... See full document
9
cis- and trans-Acting Elements in Flavivirus RNA Replication
... was essential for the replication of defective (NS5-deleted) RNA in repBHK cells ...the flavivirus RC ...conserved sequences in the N-terminal half of NS5 during their transla- ...the ... See full document
11
Template Role of Double-Stranded RNA in Tombusvirus Replication
... viral RNA using Tomato bushy stunt virus (TBSV), a tombusvirus that infects plants and is capable of replication in a yeast (Saccha- romyces cerevisiae) surrogate host (24, ...TBSV replication in ... See full document
14
A hepatitis C virus cis acting replication element forms a long range RNA RNA interaction with upstream RNA sequences in NS5B
... a role in HCV, and the previously demonstrated positional independence of SL9266 would argue strongly against any such ...the RNA structure forming SL9266, together with interactions of the 590 ... See full document
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A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... SL9266 sequences with the upstream region were important for ...upstream sequences rendered the chimera ...still replication competent, the distribution of substitu- tions within the replaced ... See full document
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