[PDF] Top 20 Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets
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Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets
... broadly cross-reactive antibody response to anti- genically distinct viruses within a subtype is an important consideration in the selection of a pandemic influenza vac- cine ... See full document
8
Evaluation of Three Live Attenuated H2 Pandemic Influenza Vaccine Candidates in Mice and Ferrets
... H2 influenza viruses have not circulated in humans since 1968, and therefore a significant portion of the population would be susceptible to infection should H2 influenza viruses ... See full document
10
Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets
... that cross-reacted with heterologous viruses less well than with the homologous ...of mice with the H6 wt virus ...protected mice and ferrets from pulmonary replication of these ... See full document
8
Evaluation of Replication and Pathogenicity of Avian Influenza A H7 Subtype Viruses in a Mouse Model
... H7 viruses in mammalian species, such as ferrets and mice, that currently are used for preclinical studies of pandemic influenza ...vaccines. Ferrets are considered the best available ... See full document
9
Avian Influenza H6 Viruses Productively Infect and Cause Illness in Mice and Ferrets
... predict cross-protection in mice; we saw evidence of cross- protection in the absence of cross-reactive neutralizing anti- ...three viruses administered to mice each ... See full document
10
Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses
... vaccine viruses among animal influenza A viruses of different subtypes, including H2, H3, H6, and H7 ...both mice and ferrets and the observation that the antisera cross-reacted ... See full document
13
Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses.
... In the experiments described below, we used sera obtained from mice after primary influenza virus infection with A/PR/8/34 A/PR; H1N1, A/Japan/305/57 A/Japan; H2N2, or A/Port Chalmers/1/[r] ... See full document
6
Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses
... of cross-protection between viruses from different clusters was confirmed in HPAI H5 vaccine studies (13, ...H5 viruses can be separated into at least 10 different clades based on phylogeny and ... See full document
19
Seasonal Influenza Vaccination Is the Strongest Correlate of Cross Reactive Antibody Responses in Migratory Bird Handlers
... in cross-protection against novel viruses (30– 32), and development of a universal vaccine targeting conserved HA stem regions, particularly those that span group 1 and group 2 HAs, is an appealing approach ... See full document
10
Replication and Immunogenicity of Swine, Equine, and Avian H3 Subtype Influenza Viruses in Mice and Ferrets
... future influenza pandemic strains is difficult; therefore, the best way to prepare for pandemics is to develop and evaluate the safety and immunogenicity of vaccines for different subtypes in preclinical and ... See full document
10
Antibody Responses toward the Major Antigenic Sites of Influenza B Virus Hemagglutinin in Mice, Ferrets, and Humans
... of cross-reactive antibodies targeting noncanonical sites presumably face a higher risk of influenza B virus infection than older ...HI antibody responses as well as total IgG responses ... See full document
11
Cross reactive human B cell and T cell epitopes between influenza A and B viruses
... [6-11]. Influenza A and B viruses have eight negative sense RNA segments as a genome, while influenza C viruses have seven ...between influenza A and B viruses [12,13]. The ... See full document
10
Evaluation of the Biological Properties and Cross-Reactive Antibody Response to H10 Influenza Viruses in Ferrets
... H10 viruses can spread between mammals and cause se- vere disease in ...H10 viruses to cross the species barrier and to identify a candidate vaccine strain, we evaluated the in vitro and in vivo ... See full document
18
The Receptor Binding Specificity of the Live Attenuated Influenza H2 and H6 Vaccine Viruses Contributes to Vaccine Immunogenicity and Protection in Ferrets
... for influenza pandemics that may be caused by the H2 and H6 subtype influenza viruses, live attenuated influenza virus (LAIV) H2 and H6 vaccines are being developed and ... See full document
7
Pathogenesis of Avian Influenza (H7) Virus Infection in Mice and Ferrets: Enhanced Virulence of Eurasian H7N7 Viruses Isolated from Humans
... H7 viruses studied here, which all possess identical HA cleavage sites that contain five basic amino acids (12), the North American H7 viruses exam- ined display far more ...occurring viruses found ... See full document
9
Comparative Pathology in Ferrets Infected with H1N1 Influenza A Viruses Isolated from Different Hosts
... H1N1 influenza virus and the pathology associated with this subtype of virus in ferrets had not been extensively studied outside the context of vaccine ...H1N1 influenza viruses or ... See full document
10
Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004
... H5N1/04 viruses in fer- rets. We inoculated ferrets with 13 different H5N1 influenza viruses isolated from humans in Vietnam and Thailand and with viruses isolated during fatal ... See full document
9
Ocular Infection of Mice with Influenza A (H7) Viruses: a Site of Primary Replication and Spread to the Respiratory Tract
... avian influenza viruses with this binding specificity would be well suited to infect this tissue and cause ocular ...of influenza viruses to bind to or replicate in ocular tissue cannot be ex- ... See full document
10
Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets
... H7N9 influenza viruses differing by four amino ac- ids, including the host determinant PB2 residue ...both viruses transmitted effi- ciently among chickens via direct contact but inefficiently via ... See full document
13
Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells
... efficient replication in all ocular cell types of HPAI viruses bearing a lysine at position 627 in PB2 suggests that this residue confers a replication advantage in both respiratory and ocular cells, ... See full document
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