[PDF] Top 20 Evidence that Productive Human Immunodeficiency Virus Type 1 Assembly Can Occur in an Intracellular Compartment
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Evidence that Productive Human Immunodeficiency Virus Type 1 Assembly Can Occur in an Intracellular Compartment
... Inhibition of the cellular endocytic pathway does not pre- vent accumulation of 29/31KE Gag in a late endosomal com- partment. It is clear from the data presented above and from our previous reports (54) that 29/31KE ... See full document
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Kinesin KIF4 Regulates Intracellular Trafficking and Stability of the Human Immunodeficiency Virus Type 1 Gag Polyprotein
... in assembly is supported by the finding that treatment of T cells with inhibitors of MT polymerization prevents forma- tion of Gag-containing assembly platforms on the plasma membrane and reduces ... See full document
14
Cytosolic Gag p24 as an Index of Productive Entry of Human Immunodeficiency Virus Type 1
... its intracellular distribution, are not reliable indicators of productive HIV ...interactions can take place, 50 to 90% of the intracellular viral material follows the endosomal degradation ... See full document
5
The Late Stage of Human Immunodeficiency Virus Type 1 Assembly Is an Energy-Dependent Process
... of evidence indicate that assembly complexes in ATP-depleted cells are stalled late in the HIV-1 assembly ...late assembly intermediates (42) ...added 1 h into the ... See full document
9
Folding, assembly, and intracellular trafficking of the human immunodeficiency virus type 1 envelope glycoprotein analyzed with monoclonal antibodies recognizing maturational intermediates.
... Although most experiments were carried out with a non- cleavable recombinant gp160, similar pulse-labeling and immu- nofluorescence results were obtained with a cleavable recom- binant protein. Moreover, the ER or Golgi ... See full document
9
Impact of Natural Polymorphism within the gp41 Cytoplasmic Tail of Human Immunodeficiency Virus Type 1 on the Intracellular Distribution of Envelope Glycoproteins and Viral Assembly
... of evidence have been put forward to suggest that Gag and Env ...the intracellular distribution of Env, with at least some Env being retained at the cell ... See full document
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Highly Productive Infection with Pseudotyped Human Immunodeficiency Virus Type 1 (HIV-1) Indicates No Intracellular Restrictions to HIV-1 Replication in Primary Human Astrocytes
... RNA 1 week after pseudotype HIV-1 infection of astrocytes revealed expression of the three major HIV-1 transcripts at similar levels; 2 or 3 weeks after infection, the 9-kb genomic transcript was ... See full document
9
Formation of Virus Assembly Intermediate Complexes in the Cytoplasm by Wild-Type and Assembly-Defective Mutant Human Immunodeficiency Virus Type 1 and Their Association with Membranes
... the intracellular localization of these two viral assembly intermediate complexes was investigated by use of a newly developed method of subcellular ...in assembly domains M and L of the Gag protein ... See full document
9
Productive Human Immunodeficiency Virus Type 1 Assembly Takes Place at the Plasma Membrane
... Gag-mediated assembly mainly occurs at the PM with accumulation of Gag and viral particles in LE/MVB resulting from an internalization process from the cell surface (22, 24, 34, ...of evidence suggest that ... See full document
15
Human Immunodeficiency Virus Type 1 Vif Is Efficiently Packaged into Virions during Productive but Not Chronic Infection
... than virus preparations from chronically infected cells (4 to 6 molecules of Vif per virion), even when virus output was boosted from the chronically infected cells through exogenous ...of ... See full document
10
OX40 Stimulation by gp34/OX40 Ligand Enhances Productive Human Immunodeficiency Virus Type 1 Infection
... FIG. 1. Enhanced expression of HIV-1 by OX40 stimulation from HIV-1 chronically infected ACH-2/OX40 ...5, 1, 0.2, or 0.04 g/ml for 1 h at 37°C and then were added to ACH-2/OX40 ... See full document
10
Productive Infection of Plasmacytoid Dendritic Cells with Human Immunodeficiency Virus Type 1 Is Triggered by CD40 Ligation
... DC/well). When indicated, following the 2-h incubation, soluble CD40L trimer (CD40LT) (gift of Immunex) was added at a final concentration of 500 ng/ml. Cell-free supernatants were collected at 24 h and assessed for ... See full document
9
Assembly Properties of Human Immunodeficiency Virus Type 1 Gag-Leucine Zipper Chimeras: Implications for Retrovirus Assembly
... of virus-like particles in mammalian ...motif can also assemble efficiently in mammalian ...analyzed assembly by chimeric proteins in which nucleocapsid of human immunodeficiency ... See full document
10
CD4-independent, productive human immunodeficiency virus type 1 infection of hepatoma cell lines in vitro.
... 6 CD4-Independent, Productive Human Immunodeficiency Virus Type 1 Infection of Hepatoma Cell Lines In Vitro YUNZHEN CAO,1 ALVIN E.. FRIEDMAN-KIEN,l YAOXING HUANG,' XI LING LI,2 MICHAEL M[r] ... See full document
7
Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression.
... HeLa CD4+ cells transfected with sense or antisense virus were cocultivated with MT4 cells, and virus production was monitored by reverse transcriptase assays of the supernatant medium..[r] ... See full document
10
Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants.
... These include productive infection, with the generation of high virus replication levels; silent infection, with low to undetectable virus replication in monocytes, despite ultimate viru[r] ... See full document
7
Evidence for Frequent Reinfection with Human Immunodeficiency Virus Type 1 of a Different Subtype
... current human immunodeficiency virus type 1 (HIV-1) vaccine approaches is that preexisting HIV-1-specific immunity will block or reduce ...second virus emerged ⬃ ... See full document
8
Kinetic Analysis of Human Immunodeficiency Virus Type 1 Assembly Reveals the Presence of Sequential Intermediates
... M 1-10 (28) (a kind gift from George Pavlakis, National Institutes of Health [NIH]), a Rev-independent form of Pr55gag, by PCR with oligonucleo- tide primers adding flanking KpnI and XbaI ... See full document
11
Analysis of the Assembly Function of the Human Immunodeficiency Virus Type 1 Gag Protein Nucleocapsid Domain
... pol frame at the HindII site at nt 2498 (21, 40). NC deletion mutants TARK, TAM, and ApoTE have translation terminators in the gag gene, causing the gag ORF to terminate 11 residues after (TARK), precisely at (TAM), or 5 ... See full document
8
Complementation of Human Immunodeficiency Virus Type 1 Replication by Intracellular Selection of Escherichia coli Supplied in trans
... The conversion of the single-stranded RNA genome of ret- roviruses into a double-stranded DNA intermediate prior to integration in the host cell chromosome requires a virally en- coded enzyme, reverse transcriptase, and ... See full document
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