[PDF] Top 20 Experimental and computational analysis of the structure and dynamics of intrinsically disordered proteins

... sequence analysis illustrates that, compared to NRF2 site 1, PALB2 has considerably less hydrophobic content in its binding region, which may allow for more conformational ... See full document

... and dynamics characteristic of self-associating polymers and thus are expected to undergo liquid-liquid phase ...the experimental observations made on FG domains so far and suggested that both 'brush-like' ... See full document

... and experimental difficulties hindering their studies, it is important to develop computational techniques that would permit greater insight into the behav- iour of this class of ...protein structure ... See full document

... Introduction Intrinsically disordered proteins (IDPs) have attracted a lot of attention in recent years based on the discovery of their impor- tance in eukaryotic life and their central role in ... See full document

... small proteins or peptides (in all but two cases smaller than 60 residues) and they often require a starting experimental structure as ...the disordered behaviour of proteins, although ... See full document

... Low-throughput experimental studies that reveal PPIs are not only expensive and labour-intensive, but also suffer from bias in favour of well-studied ...rigorous experimental testing or eliminate those less ... See full document

... 15. Dunker AK, Obradovic Z, Romero P, Garner EC, & Brown CJ (2000) Intrinsic Protein Disorder in Complete Genomes. Genome Inform Ser Workshop Genome Inform, 11:161-171. 16. Ward JJ, Sodhi JS, McGuffin LJ, Buxton BF, ... See full document

... for intrinsically disordered proteins (IDPs) that are involved in cellular signaling and ...recent computational and experimental study of cell-cycle regulator p27 (Ganguly et ... See full document

... (Non-globular proteins: From sequence to structure, function and application in molecular physiopathology), a sci- entific cooperation funded in 2015 under a Horizon 2020 EU Framework ...of ... See full document

... the structure and function of IDPs has highlighted the need to exploit text-mining approaches in order to eventually lever- age automatic annotation from the ...coordinated experimental and ... See full document

... Previous analysis of existing Bcl-xL structures and atomistic molecular dynamics (MD) simulations have suggested that substantial intrinsic structure heterogeneity exists at the BH3-only protein ... See full document

... tertiary structure. The view that protein sequence defines the 3D structure, which determines function, has been widely ...functional proteins. It turns out that for some proteins, termed as ... See full document

... Intrinsically disordered proteins (IDPs) are ubiquitously involved in cellular processes and often implicated in human pathological ...these proteins, despite not adopting a well-defined fold, ... See full document

... of proteins in the yeast ribosome were compared to the ribosome structure to determine whether regions predicted to be involved in bind- ing of proteins and RNa actually perform these ...13 ... See full document

... condensate-specific environment. Demonstrating the functional relevance of this postulate has been challenging; the best example to date is from Nott et al., who showed that the inte- rior of the Ddx4 droplet ... See full document

... of intrinsically disordered proteins involved in ...secondary structure, the model generates conformational ensembles conforming to structural predictions from atomistic ...of ... See full document

... fast experimental one only if the model allowed for non- native contacts to occur, leading to a broad distribution of encounter complexes productive for binding ( De Sancho and Best, 2012 ...ordered ... See full document

... the dynamics of each intrinsically disordered ...is disordered. Furthermore, a disordered region with conformational bias can be detected by this method, which is particularly ... See full document

... Intrinsically disordered proteins (IDPs) are involved in metabolic regulation, signalization, controlling pathways and in various types of biotic and abiotic ...globular proteins, and IDPs ... See full document

... Chapter 1. Introduction 3 facilitate promoter-enhancer interactions associated with segmentation and other developmental processes. In vertebrates, the involvement of Ldb1 in looping has focussed on the β-globin locus. ... See full document