[PDF] Top 20 Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice.

... We draw this conclusion on the basis of our observations that i the HBsAg concentration in serum shows an inverse relationship with the intracellular large envelope polypeptide concent; [r] ... See full document

... 2 Tissue Preferential Expression of the Hepatitis B Virus HBV Surface Antigen Gene in Two Lines of HBV Transgenic Mice ROBERT D.. GEARHART3 Department of Pediatrics and Marion Bessin Liv[r] ... See full document

... 4069 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Two lines of hepatitis B virus HBV transgenic mice, designated G7 and G26, show preferential expression of the 2.1-[r] ... See full document

... While expression of HDAg is not directly cytotoxic to the transgenic mouse hepatocyte in vivo, we tested the possibility that the expression of this antigen could sensitize the hepatocyt[r] ... See full document

... 3, the 160-nucleotide-long HBV-specific protected fragment was selectively reduced in the cytoplasmic compartment 16 h after injection of IL-2, corresponding to the decrease in the 2.1-k[r] ... See full document

... our transgenic mice with those in six chronically infected human ...Developmental expression of viral RNA. The kinetics of hepatic expression of HBV mRNA was examined for lineages ...newborn ... See full document

... single-transgenic mice ( ; 50 ...precore expression vector with a replication-competent plas- mid at a 1:20 ratio significantly reduced HBV replication in HepG2 cells ...expressing large ... See full document

... and antigen-specific immune responses, due in part to the enhanced production of Th1-type ...recombinant hepatitis B surface antigen (HBsAg) to induce Th1 responses in mice that ... See full document

... the expression of the IL-18 receptor as others have shown in T cells (15, ...IFN-␣/␤ expression, and by a 20-, 6-, and 17-fold increase in the number of intrahepatic NK cells, T cells, and macrophages ... See full document

... Although the expression of mouse AAT protein in the transgenic mice remained high throughout the life span of the animals 43, the pattern of transgene expression in the ATX transgenic mi[r] ... See full document

... 12-treated mice results in increased amounts of these ...HBV transgenic mice were injected intraperitoneally either with antibody specific for murine TNF-a (38), IFN-g (36), or IFN-a/b (14) or ... See full document

... DNA virus in the Hepad- naviridae ...polymerase, envelope protein, precore protein (which is pro- cessed to viral capsid), and protein ...HBV envelope, termed the S protein; (ii) a protein with 55 ... See full document

... HBsAg expression and subsequently reduced HBsAg, HBV DNA, and HDV RNA in the media despite the fact that the HBV DNA in nucleocapsids produced by this HBV plas- mid is at a moderate level compared to the remaining ... See full document

... expression of the wild-type L and L.N4, 112Q double mutant in HEK 293T cells, lysates were mock-treated or treated with PNGase F prior to L-specific immunoblot- ting. As shown in Fig. 3, the combined mutation of ... See full document

... Concurrence of Hepatitis B Surface Antigen and Antibody in Acute and Chronic Hepatitis B Cases ORIGINAL ARTICLE Concurrence of Hepatitis B Surface Antigen and Antibody in Acute and Chronic Hepatitis B[.] ... See full document

... to large amounts of viral antigens, as demonstrated for hepatitis B e antigen (HBeAg) [19,20], while the effects of hepatitis B surface antigen (HBsAg) in this ... See full document

... Bispecific antibodies have immense potential for use in clinical applications. In the present study, a bispecific diabody against human red blood cells (RBCs) and hepatitis B virus surface ... See full document

... for insertions in this area is assumed (15). The results achieved in this work also argue for an immunologic importance of amino acids 118 to 123. The deletions found in isolates F2 and F4, as well as amino acid changes ... See full document

... the hepatitis B surface antigen (HBsAg) carrier ...to hepatitis B core antigen (anti-HBc) in cultures containing peripheral blood mononuclear cells from chronic HBsAg ... See full document

... four mice given intraperitoneal injections of 2 m g of recombinant HBsAg with complete Freund’s adjuvant and bled 4 weeks after ...Organization hepatitis B Ig reference preparation and expressed as ... See full document