[PDF] Top 20 The Extracellular Domain of Herpes Simplex Virus gE Is Sufficient for Accumulation at Cell Junctions but Not for Cell-to-Cell Spread
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The Extracellular Domain of Herpes Simplex Virus gE Is Sufficient for Accumulation at Cell Junctions but Not for Cell-to-Cell Spread
... Whether gE/gI is directed exclusively to basolateral do- mains, in the case of wild-type HSV-1, or moves to both apical and basolateral surfaces, in the case of F-gE⌬CT, there was obvious ... See full document
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Herpes Simplex Virus gE/gI Expressed in Epithelial Cells Interferes with Cell-to-Cell Spread
... at cell junctions. Given the effects of gE/gI on sorting of virus particles described previ- ously (23), gE⌬CT/gI expression might potentially cause intra- cellular accumulation ... See full document
10
Herpes Simplex Virus gE/gI Must Accumulate in the trans-Golgi Network at Early Times and Then Redistribute to Cell Junctions To Promote Cell-Cell Spread
... 49). gE/gI TGN localization appears to be important for virus assembly and as a first step towards the selective sorting of enveloped particles to cell junctions, which promotes ... See full document
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Herpes Simplex Virus gE/gI Sorts Nascent Virions to Epithelial Cell Junctions, Promoting Virus Spread
... alphaherpesviruses spread effectively from cell to cell in solid tissues are poorly ...Since gE/gI functions selectively in this process, and not in entry of extracellular virus ... See full document
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Herpes Simplex Virus gE/gI Extracellular Domains Promote Axonal Transport and Spread from Neurons to Epithelial Cells
... the gE in HSV-infected cells and virions is bound by gI, and both gE/gI are required for cell-to-cell spread ...HSV gE/gI one protein. gE and gI each contain ⬃ ... See full document
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The Extracellular Domain of Herpes Simplex Virus gE Is Indispensable for Efficient Cell-to-Cell Spread: Evidence for gE/gI Receptors
... how gE/gI promotes cell-to-cell spread has been difficult to unravel, even compared with the complex problem of how HSV enters cells ...HSV gE/gI and those of PRV gE/gI have ... See full document
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Responses of Herpes Simplex Virus Type 1-Infected Cells to the Presence of Extracellular Antibodies: gE-Dependent Glycoprotein Capping and Enhancement in Cell-to-Cell Spread
... viral gE-gI complexes via the Fc domain (data not ...against gE, gB, or gC could not induce a concerted capping of cell surface glyco- proteins, although clustering of the individual proteins ... See full document
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Cytoplasmic Domain of Herpes Simplex Virus gE Causes Accumulation in the trans-Golgi Network, a Site of Virus Envelopment and Sorting of Virions to Cell Junctions
... CT domain was found largely on the apical and lateral cell surfaces, as was wild-type ...CT domain of HSV gI does not, on its own, cause TGN localization in these ...without gE by trans- ... See full document
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Herpes Simplex Virus 1 pUL34 Plays a Critical Role in Cell-to-Cell Spread of Virus in Addition to Its Role in Virus Replication
... of herpes simplex virus (HSV) during recur- rent disease in the host is dependent upon efficient viral rep- lication and on the ability of the virus to spread from cell to ... See full document
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The Herpes Simplex Virus gE-gI Complex Facilitates Cell-to-Cell Spread and Binds to Components of Cell Junctions
... Herpes simplex virus (HSV) replicates in tissues of epithelial origin such as the oral and genital mucosae and corneal epi- ...extensive cell contacts or junctions, and HSV and other ... See full document
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Role of mannose-6-phosphate receptors in herpes simplex virus entry into cells and cell-to-cell transmission.
... for virus entry into cells, promoting virus interactions with a rela- tively restricted set of cell surface receptors at a stage subse- quent to adsorption onto cell surface ...from ... See full document
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Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread
... binding domain could be identified within gB based on analysis of the predicted amino acid sequence of the gB gene ...increase virus infection of cells low in adeno- virus receptor density ... See full document
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Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral Glycoprotein-Glycosaminoglycan Interactions To Inhibit Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread
... for virus binding but prevents entry (41). Using ELISA to detect bound virus on the adherent cells, both tannin compounds were observed to inhibit HSV-1 attachment to the A549 cell surface in a ... See full document
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Analysis of the Role of Autophagy in Replication of Herpes Simplex Virus in Cell Culture
... ICP34.5-deficient virus in culture are due to high levels of phosphorylated eIF2 ␣ and subsequent shutoff of viral protein ...binding domain did not affect the ability of ... See full document
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Redistribution of Cellular and Herpes Simplex Virus Proteins from the Trans-Golgi Network to Cell Junctions without Enveloped Capsids
... whether gE/gI and TGN46 were redistributed to epithelial cell junctions in the absence of cytosolic capsids, HEC-1A cells were infected with ...cells, gE/gI was found in perinuclear vesicles ... See full document
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Role of cell-associated enveloped vaccinia virus in cell-to-cell spread.
... Cell-associated virus A and B, virus released to the medium by trypsin C and D, and extracellular virus E and F were isolated from WR-infected cells A, C, and E or IHD-J infected cells B[r] ... See full document
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Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion
... (ii) Fusion in the absence of receptor. We next attempted to quantify fusion in the absence of receptor using the split luciferase assay. However, this proved to have inconsistent results, presum- ably because ... See full document
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Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell-cell fusion.
... The results of this study reinforce the view that the two processes of fusion of the HSV envelope with a cellular membrane and fusion of an infected cell membrane with its neighbor, whil[r] ... See full document
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Interplay between the Herpes Simplex Virus 1 gB Cytodomain and the gH Cytotail during Cell-Cell Fusion
... gB-mediated cell-cell fusion appears restricted by its intraviral or cytoplasmic domain (cytodomain) because mutations within it result in a hyperfusogenic ...in cell-cell fusion at ... See full document
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Identification of herpes simplex virus type 1 glycoproteins interacting with the cell surface.
... 2491 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To investigate the interaction of herpes simplex virus type 1 HSV-1 with the cell surface, we studied the formation[r] ... See full document
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