[PDF] Top 20 Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 Is Regulated by Phosphorylation at a Specific Site

... all capsid proteins of HSV-1 have previously been reported to be phosphorylated in infected cells, as described above, the biological significance of HSV-1 capsid phosphoryla- tion, as well as ... See full document

... the phosphorylation of UL51 in HSV-1 ...of phosphorylation at UL51 Ser-184 and gE-null mutation synergistically reduced HSV-1 cell-cell spread in HaCaT ...UL51 function for the ... See full document

... The herpes simplex virus 1 (HSV-1) UL12 protein (pUL12) is a nuclease that is critical for viral replication in vitro and neuro- virulence in ...pUL12 phosphorylation ... See full document

... incoming herpes simplex virus type 1 (HSV-1) capsids along microtubules (MT) to the MT-organizing center ...The small capsid protein VP26 can interact with ... See full document

... of VP26 clearly eliminates the possibility that accessibility of the binding site is controlling ...horn-shaped VP26 densities on the top of each ... See full document

... ABSTRACT VP26 is a herpes simplex virus 1 (HSV-1) small capsomere-interacting ...the function of VP26 in HSV-1-infected cells with the following ... See full document

... and protein kinase A have been implicated in their subcellular localization, and putative phosphorylation sites for these cellular kinases have been identified in region III of ...the phosphorylation ... See full document

... be regulated by phosphorylation; however, the role of phosphorylation in OBP function has been difficult to assess due to the low level of OBP expression in HSV-infected ...and ... See full document

... a protein mass of ⬃100 kDa when the partial specific volume of protein is taken into ...T36 capsid isolated at 4°C; (C) T36 capsid isolated at ...T36 capsid are ... See full document

... The small size of the density seen on AR⌬UL36 and K⌬UL36 capsids indicates that pUL17 and pUL25 alone do not account for the published struc- tures and generates uncertainty over the relative positions and ... See full document

... the phosphorylation sites of ICP27 in vivo by using frameshift mutant N6R, we were surprised to find that this mutant, which encodes ICP27 from amino acids 1 to 163, was phosphorylated as efficiently as the ... See full document

... Suz12 colocalized to CTCF insulators flanking the IE regions of HSV-1 during latency. In mammalian genomes, it was demonstrated that CTCF interacted with the protein Suz12 in the PRC2 complex, leading to ... See full document

... near capsid pentonic vertices, compared to occupancy of CVSC ...to virus replication because pU L 31 and pU L 34 must disassociate from the capsid before capsids are released into the cytosol, while ... See full document

... 2009 Herpes simplex virus 1 (HSV-1) protein ICP27 is a multifunctional regulatory protein that is posttransla- tionally modified by phosphorylation during viral ... See full document

... the capsid exterior around penton vertices, from where packaged viral DNA is presum- ably ...this site where the DNA enters the capsid and likely their activity in packaging and maintaining the ... See full document

... the site of reenvelopment, al- though we cannot rule out that the in vitro assay inefficiently re- produces this tegumentation step due to, for example, a lower protein concentration in vitro (1 ... See full document

... of protein tyrosine phosphatases ...in protein tyrosine phosphorylation in HSV- inactivated lymphocytes in order to gain further insight into the mechanism of ...rosine-phosphorylated protein, ... See full document

... for function both in the yeast two-hybrid assay for interaction with VP19C and in a genetic complementation assay for the ability to support the replication of a VP23 null mutant ...VP23 function. ... See full document

... bound VP26 or whether VP26 is recruited following shell ...expressed VP26 and by direct visualization of a transiently expressed VP26-green fluorescent protein fusion, we show that ... See full document

... the virus particle and for monitoring the virus nucleocapsid during replication and transport in cell culture and in ...the VP26 polypeptide, which is located on the outer surface of the ... See full document