[PDF] Top 20 Function and membrane targeting of the multidrug resistance associated protein 2
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Function and membrane targeting of the multidrug resistance associated protein 2
... Analysis of expression of cMOAT MRP2, MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene MRPl, in human cancer cell lines.. Expression of human MRP6, a [r] ... See full document
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ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
... Table 2. Especially, the ABC transport- ers have shown to function as an efflux pump for lipid, multiple drugs, natural products and ...the membrane bilayer to the exterior, driven by the energy of ... See full document
13
miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1
... predicted targeting region for miR-145 binding (nt 1728-1734, ACUGGA), was mutated (Figure 3A, labeled as mt ABCC1 ...conserved targeting region (UCC) was specifically mutated (Figure 3C, labeled as ... See full document
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Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei
... Membrane transporters, such as the Plasmodium falciparum chloroquine resistant transporter (pfcrt) and the Plasmo- dium falciparum mdr1, which is a member of the ABC superfamily, have been identified as key ... See full document
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INFLUENCE OF MULTIDRUG RESISTANCE PROTEIN-2 GENETIC POLYMORPHISM ON THE PHARMACOKINETICS OF MYCOPHENOLATE MOFETIL IN THAI KIDNEY TRANSPLANT PATIENTS
... SNPs leading to altered MRP-2 activity might influence this process and therefore affect MPA exposure. [10,11] The most extensive study was a SNP that involved a C to T transition at position -24 on promoter ... See full document
6
Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein
... the function of wild-type (WT) MtrD and construct a set of isogenic ...of resistance would be solely due to manipulation of ...NorM multidrug efflux pump would have provided in the assessment of MtrD ... See full document
14
Targeting multidrug resistance in cancer by natural chemosensitizers
... Major ABC transporters involved in MDR of cancer The assembly of different ABC efflux transporters across cell membrane is similar. It is composed of transmem- brane domains (TMDs) each contains a number of ... See full document
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Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug resistance-associated Protein 2 without Affecting Xenobiotic-metabolizing Enzymes in Rat Liver
... increased protein expressions of Mrp2/3 and p-glycoprotein also play a role in detoxification ...These membrane proteins can be induced and protect normal tissues from endogenous and exogenous toxic ... See full document
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The cloning and characterisation of a multidrug resistance associated protein (MRP) from wheat
... may function as a GS-X pump, and therefore play a role in xenobiotic ...vacuolar membrane (Martinoia, et ah, ...vacuolar membrane could not be confirmed ... See full document
204
Lapatinib Antagonizes Multidrug Resistance-Associated Protein 1-Mediated Multidrug Resistance by Inhibiting Its Transport Function
... receptor 2 (HER2). Lapatinib can modulate the function of ATP-binding cassette (ABC) transporters (ABCB1 and ABCG2), which are the major mechanism responsible for multidrug resistance (MDR) in ... See full document
10
Pattern of ABCC Transporter Gene Expression in Pediatric Patients with Relapsed Acute Lymphoblastic Leukemia
... the multidrug resistance related protein (MRP1) and the lung resistance protein (LRP) in de novo and relapsed childhood acute lymphoblastic ...The multidrug ... See full document
10
ISOLATION AND ANTIBIOGRAM PROFILE OF MULTIPLE DRUGS RESISTANCE PSEUDOMONAS AERUGINOSA FROM BURN WOUND INFECTION IN WESTERN NEPAL
... The purpose of the present study was to describe the isolation and identification of Pseudomonas aeruginosa in burn patients and to study antibiotic susceptibility patterning of Pseudomonas aeruginosa. Out of 184 sample, ... See full document
5
The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
... P-gp confers resistance to cytotoxicity by chemotherapy drugs, cytokine TNF-alpha, and ultraviolet light [21]. Fag- gad et al. [22] found that MRP1 expression was as an inde- pendent negative prognostic factor for ... See full document
6
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... androgen-induced protein; P-gp=P-glycoprotein; KO= knockout; WT=wild-type; BCRP=breast cancer resistance protein; MRP1=multidrug resistance-associated protein ... See full document
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Expression of Multidrug Resistance ATP Binding Cassette (ABC) Transporters in Canine Mammary Tumors
... 2000 Increased Expression of an ATP-Binding Cassette Superfamily Transporter, Multidrug Resistance Protein 2, in Human Colorectal Carcinomas.. and Gerlach, J.H.[r] ... See full document
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<p>Research Progress Evaluating the Function and Mechanism of Anti-Tumor Peptides</p>
... whole protein and small molecule, and it has high targeting ability, high penetrability, low immunogenicity, and is convenient to synthesize and easy to ... See full document
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Expression of multidrug resistance proteins is localized principally to the Malpighian tubules in larvae of the cabbage looper moth, Trichoplusia ni
... in resistance to heavy metals through efflux of their glutathione conjugates (Broeks et ...in resistance to some ...the multidrug resistance proteins TrnMRP1 and TrnMRP4 expressed in the ... See full document
8
Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter
... Targeted therapy currently is one of the major strategies for cancer therapy, which suppresses the growth of cancer cells by inhibiting specific molecular targets required for cancer growth. Small molecular agent is the ... See full document
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Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine
... Dulbeccos' Modified Eagles' Medium (DMEM), NAC, BSO, geneticin, Feotal Bovine Serum (FBS), and other chemicals were purchased from Sigma-Aldrich Corp. St. Louis, MO, USA. Vincristine was obtained from Oncology Department ... See full document
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In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin
... artemisinin resistance markers mainly targeting the implicated genes Pfk13, Pfmdr1 and Pfubcth associated with reduction in drug efficacy should be ... See full document
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