[PDF] Top 20 Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells.
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Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells.
... By examining the effects of selected targeted mutations of Tat on the abilities of hybrid Tat/Rev proteins to rescue the expression of unspliced mRNA via the TAR, we demonstrated that re[r] ... See full document
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Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells.
... This result indicated that the defect in rodent cells is not due to a protein or proteins that interact with the activation domain of Tat; rather, the defect resides in the RNA-binding d[r] ... See full document
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A human chromosome 12-associated 83-kilodalton cellular protein specifically binds to the loop region of human immunodeficiency virus type 1 trans-activation response element RNA.
... ian virus 40 early ...posttransfection, cells were harvested by incubation in cold phosphate-buffered saline with 2 mM EDTA; one half of each cell culture was taken for analysis of CAT and b ... See full document
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Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.
... HL3T1 cells before and after Tat transactivation, we detected major changes occurring at the Sp1 boxes adjacent to the enhancer region and at the downstream k B box of the ...protein-protein ... See full document
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Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.
... for Tat-mediated trans ...abolished Tat trans activation (4, 46, ...on Tat inducibility (4, 37, 38). In fact, physical interactions be- tween Tat and TATA-binding ... See full document
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Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region
... protein-protein interactions that ultimately alter gene ...the Tat protein of human immunodeficiency virus type 1 (HIV-1) is a substrate for one such enzyme, termed ... See full document
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Interactions between human immunodeficiency virus type 1 and human cytomegalovirus in human term syncytiotrophoblast cells coinfected with both viruses.
... HIV-1 tat gene expression has been reported to enhance HCMV synthesis ...in human osteosarcoma cells genetically engineered to contain an envelope-deficient HIV-1 proviral construct, ... See full document
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Functional Analysis of the Complex trans-Activating Response Element RNA Structure in Simian Immunodeficiency Virus
... quence analysis of the 5 ⬘ ends of the viral transcripts did indeed reveal that transcription of SIV-rtTA- ⌬ TAR fre- quently started downstream of the original ⫹ 1 position (2 or more nt downstream [data ... See full document
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Human GLI-2 Is a Tat Activation Response Element-Independent Tat Cofactor
... and Tat-TBP ...TG-rich element to which GLI- 2/THP binds (not shown) was necessary for GLI-2/THP-Tat synergy, neither Tat nor GLI-2/THP was directly responsible for recruiting the complex to ... See full document
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Potent Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Gene Expression and Virus Production by an HIV-2 Tat Activation-Response RNA Decoy
... either human immunode- ficiency virus type 1 (HIV-1) or ...the cells of the immune system re- sistant to HIV replication (reviewed in references 22 and ...and Tat. Rev and ... See full document
5
Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.
... with Tat leads to increased transcription. The transcriptional activation property of the HIV-1 Tat protein in cell extracts from HeLa cells is dependent on functional Tat ... See full document
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Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells.
... anti-human immunodeficiency virus type 1 (HIV-1) therapy in this ...HIV-1-infected cells, HIV-1 LTR was ...inhibited Tat-mediated transactivation in ... See full document
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Functional Interactions between C/EBP, Sp1, and COUP-TF Regulate Human Immunodeficiency Virus Type 1 Gene Transcription in Human Brain Cells
... cooperation between NF-IL6 and NF-B (49) or through the basal transcriptional machinery ...cell type. In monocytic U937 cells, the basal LTR sites retained half of NF-IL6 responsiveness, while in ... See full document
9
Functional Differences between Human and Bovine Immunodeficiency Virus Tat Transcription Factors
... other Tat proteins can bind to TAR only as part of a CycT1-Tat ...free Tat would not be able to compete with CycT1-Tat complexes for TAR binding, thus preventing any inhibition of transacti- ... See full document
6
Replication of Human Immunodeficiency Viruses Engineered with Heterologous Tat-Transactivation Response Element Interactions
... BIV Tat RNA- binding domain to ...hybrid virus containing HIV-1 TAR and the BIV Tat domain ...BIV Tat binds only weakly to HIV-1 TAR (14, ...which Tat or TAR had been ... See full document
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Inhibition of human immunodeficiency virus type 1 Tat-dependent activation of translation in Xenopus oocytes by the benzodiazepine Ro24-7429 requires trans-activation response element loop sequences.
... 25-33 0022-538X/94/$04.00 + 0 Copyright © 1994, American Society for Microbiology Inhibition of Human Immunodeficiency Virus Type 1 TatDependent Activation of Translation in Xenopus Oocy[r] ... See full document
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Human immunodeficiency virus Tat induces functional unresponsiveness in T cells.
... T cells were isolated by rosetting twice with neuraminidase- treated sheep ...T cells was ...(non-T cells) was used as antigen- presenting cells (APC). CD4 1 and CD8 1 T ... See full document
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Role of tumor necrosis factor alpha in activation and replication of the tat-defective human immunodeficiency virus type 1.
... Whereas in acute HIV-1 infection, Tat is the major transcriptional transactivator, the activation of the HIV-1 LTR and the latent endogenous HIV-1 provirus by different extracellular sti[r] ... See full document
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Single-Molecule Analysis of Human Immunodeficiency Virus Type 1 gp120-Receptor Interactions in Living Cells
... for virus-cell attach- ment remain poorly defined for living cells and at the single- molecule ...binding interactions between HIV-1 and its host ...single-molecule analysis does ... See full document
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Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation.
... DISCUSSION The main conclusion from this analysis is that sequence alterations in TAR which affect its in vivo function, as measured in various transactivation assays, have a similar eff[r] ... See full document
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