[PDF] Top 20 Functional Correlates of Insertion Mutations in the Protease Gene of Human Immunodeficiency Virus Type 1 Isolates from Patients
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Functional Correlates of Insertion Mutations in the Protease Gene of Human Immunodeficiency Virus Type 1 Isolates from Patients
... an insertion was confirmed in the four instances where additional patients’ specimens were ...of insertion mutations in the protease gene showed that the nucleic acid ... See full document
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Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.
... in protease acti- vation in those particles which are not ...wild type, but this decrease is likely due to a change in antigenicity of the mature CA since the amount of MA is the same in all of the ... See full document
9
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
... the human immunodeficiency virus type 1 (HIV-1) ...which patients initiated therapy with suboptimal dosages of IDV, we monitored the emergence of viral resistance to the ... See full document
7
Human Immunodeficiency Virus type 1 reverse transcriptase and protease gene mutations: An observational and prediction study on antiretroviral interactions and co-receptor usage.
... drawn from HIV-1 infected individuals who were referred to the clinical virology department for CD4 and/or HIV-1 viral load determination as part of patient management by physicians of the ... See full document
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Genetic and Functional Diversity of Human Immunodeficiency Virus Type 1 Subtype B Nef Primary Isolates
... the functional integrity of seven primary Nef isolates: five from a long-term nonpro- gressing human immunodeficiency virus (HIV)-infected individual and one each from two ... See full document
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The Impact of Individual Human Immunodeficiency Virus Type 1 Protease Mutations on Drug Susceptibility Is Highly Influenced by Complex Interactions with the Background Protease Sequence
... sequences from thousands of virus ...the protease amino acids in existing viruses are feasible only on a small ...mature gene assembly technologies makes the large-scale generation of closely ... See full document
9
Mutation Patterns and Structural Correlates in Human Immunodeficiency Virus Type 1 Protease following Different Protease Inhibitor Treatments
... many human immunodeficiency virus type 1 (HIV-1)-infected persons are treated with multiple protease inhibitors in combination or in succession, mutation patterns of ... See full document
12
Human Immunodeficiency Virus Type 1 Protease Cleavage Site Mutations Associated with Protease Inhibitor Cross-Resistance Selected by Indinavir, Ritonavir, and/or Saquinavir
... The human immunodeficiency virus (HIV) protease must recognize and cleave up to 12 sites, each with a different amino acid sequence, in the Gag and Gag-Pol precursor polypeptides (18) and in ... See full document
6
Monitoring Resistance to Human Immunodeficiency Virus Type 1 Protease Inhibitors by Pyrosequencing
... four patients. The virus harbored by patient 2 had four primary mutations and ap- peared to be resistant to IDV, RTV, and ...characteristic mutations that confer resistance (32), so this ... See full document
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Positive Selection Pressure Introduces Secondary Mutations at Gag Cleavage Sites in Human Immunodeficiency Virus Type 1 Harboring Major Protease Resistance Mutations
... treatment from the Danish HIV Cohort Study, which is described elsewhere ...HIV patients seen in the eight Danish HIV clinics since 1 January ...5,300 patients. HIV sequences were obtained ... See full document
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Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
... observed mutations in Gag cleavage sites that have been selected in response to saquinavir, ritonavir, indi- navir, lopinavir, and other experimental inhibitors (11, 23, 46, ...47). Mutations have been ... See full document
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Polymorphism and Drug Selected Mutations in the Protease Gene of Human Immunodeficiency Virus Type 2 from Patients Living in Southern France
... HIV-2 protease sequences (68 and 32% belonging to subtypes A and B, respectively) and found that all of them harbored at least four positions associated with PI resistance in HIV-1 at amino acids 10, 32, ... See full document
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Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria.
... Using this expression plasmid as a substrate for mutagenesis, we have constructed a panel of linker insertion mutations distributed throughout gag and assayed the effect of these mutatio[r] ... See full document
5
Identification of Biased Amino Acid Substitution Patterns in Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Protease Inhibitors
... NC mutations at position 93 ranked tied 29 to 54 in the empirical distribution (28 random pairings had higher counts, 9,946 had lower counts), giving a conservative tail probability of 54/10,001 5 ...in 1 ... See full document
6
Cleavage of the Murine Leukemia Virus Transmembrane Env Protein by Human Immunodeficiency Virus Type 1 Protease: Transdominant Inhibition by Matrix Mutations
... after virus budding by the viral protease ...anemia virus (56), and Mason- Pfizer monkey virus (M-PMV) (1, 2, 59), has been reported to activate the fusion potential of the Env ... See full document
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Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... Table 1, neither the wild-type virus nor the V32I/V82I mutant showed any decrease in infectivity when the infection was done in the presence of the PR inhibitor at concentrations between ...of ... See full document
5
Expression of active human immunodeficiency virus type 1 protease by noninfectious chimeric virus particles.
... Attempts to detect RT in MoHIV-I and MoHIV-III cell lysates and virion particles by immunoblot analysis were consistently negative under conditions in which the protein was readily detec[r] ... See full document
8
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
... WT virus, but with a delay of 4 days ...modest virus assembly defects in the 293T overexpression system, have even more severe phe- notypes in peripheral blood mononuclear cells or T cells ...tal ... See full document
12
Effect of a Protease Inhibitor-Induced Genetic Bottleneck on Human Immunodeficiency Virus Type 1 env Gene Populations
... released from the vector by digestion with KpnI, and then the reaction mixture was brought up to a final volume of 150 ...of 1 l 10 ⫻ annealing buffer (1 M NaCl, 100 mM Tris-HCl [pH ...EDTA), ... See full document
11
Comprehensive Bioinformatic Analysis of the Specificity of Human Immunodeficiency Virus Type 1 Protease
... It was surprising to find the data set to be linearly separable when sparse orthogonal encoding was used (Fig. 2). The prob- ability that this would happen by chance is so extremely low that it must say something about ... See full document
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