[PDF] Top 20 Functional Relevance of the N-Terminal Domain of Pseudorabies Virus Envelope Glycoprotein H and Its Interaction with Glycoprotein L
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Functional Relevance of the N-Terminal Domain of Pseudorabies Virus Envelope Glycoprotein H and Its Interaction with Glycoprotein L
... impaired virus entry, penetration studies were carried ...input virus protected from inactivation by low-pH treatment after 15 min at 37°C ...4 h, only 60 to 70% of the infectious particles of ... See full document
16
Functional Relevance of the Transmembrane Domain and Cytoplasmic Tail of the Pseudorabies Virus Glycoprotein H for Membrane Fusion
... fulfill its function and which role the gH cytoplasmic (CD) and transmembrane domains (TMD) play in fusion is ...simplex virus 1 (HSV-1) seems to be suffi- cient to mediate cell-cell fusion in transient ... See full document
14
Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virion localization of glycoprotein H.
... for Virus Diseases of Animals, D-72076 Tu ¨bingen, 2 Germany Received 21 April 1997/Accepted 26 June 1997 Herpesviruses contain a number of envelope glycoproteins which play important roles in the ... See full document
9
Functional Role of N-Linked Glycosylation in Pseudorabies Virus Glycoprotein gH
... viral envelope with cellu- lar membranes, which involves the conserved fusion machinery consisting of gB and the heterodimeric gH/gL ...Viral envelope glycoproteins, such as gH, usually contain ... See full document
18
Structure-Based Functional Analyses of Domains II and III of Pseudorabies Virus Glycoprotein H
... of pseudorabies virus gH, a part of the core fusion machinery of ...in domain IV of PrV gH is important for its ...within domain II that inter- fere with integrity or flexibility of a ... See full document
13
The amino-terminal one-third of pseudorabies virus glycoprotein gIII contains a functional attachment domain, but this domain is not required for the efficient penetration of Vero cells.
... Glycoprotein gIII was found in the virus envelope of strains PRV-Be, PRV523, PRV2, and PRV505, but, because of their deletions, the mutant glycoproteins migrated differently from wild-ty[r] ... See full document
9
Structure-Based Mutational Analysis of the Highly Conserved Domain IV of Glycoprotein H of Pseudorabies Virus
... of Glycoprotein H of Pseudorabies Virus Walter Fuchs, a Marija Backovic, b Barbara ...b Glycoprotein H (gH) is an envelope protein conserved in the ...with ... See full document
12
A Novel Zinc-Binding Domain Is Essential for Formation of the Functional Junín Virus Envelope Glycoprotein Complex
... The envelope glycoprotein of the Junı´n arenavirus (GP-C) mediates entry into target cells through a pH- dependent membrane fusion ...cytoplasmic domain (CTD) of the transmembrane fusion ... See full document
7
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein.
... the functional relevance of this phenomenon remains to be estab- lished, these results suggest that CD4 binding can alter gp120- gp41 ...gp120 glycoprotein, since, in contrast to shedding, it occurs ... See full document
10
Characterization of the Prototype Foamy Virus Envelope Glycoprotein Receptor-Binding Domain
... foamy virus (FV) glycoprotein precursor gp130 Env undergoes a highly unusual biosynthesis, resulting in the generation of three particle-associated, mature subunits, leader peptide (LP), surface (SU), and ... See full document
10
Identification of New Functional Regions in Hepatitis C Virus Envelope Glycoprotein E2
... putative interaction with the membrane ...and its location up- stream of the TM domain of E2 suggest that it is located at the membrane interface, maybe in an in-plane ... See full document
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Internalization of Pseudorabies Virus Glycoprotein B Is Mediated by an Interaction between the YQRL Motif in Its Cytoplasmic Domain and the Clathrin-Associated AP-2 Adaptor Complex
... cytoplasmic domain of pseudorabies virus (PRV) glycoprotein B (gB) contains three putative internal- ization ...efficient interaction between gB and AP-2 required an intact YQRL ... See full document
8
The Carboxy-Terminal Domain of Glycoprotein N of Human Cytomegalovirus Is Required for Virion Morphogenesis
... infectious virus from BAC-UL73 ⌬127 and BAC-UL73cHSV which both contain cysteines 125 and ...for virus replication and perhaps secondary to its interaction with additional pro- ... See full document
13
Identification and characterization of pseudorabies virus glycoprotein H.
... These results show that (i) gH(PrV), as detected by our antisera in purified virion preparations, does indeed constitute a glyco- sylated protein; (ii) approximately S kDa of endo H-sens[r] ... See full document
8
A cellular function is required for pseudorabies virus envelope glycoprotein processing and virus egress.
... infection, there is a second block to export from late Golgi compartments (possible the trans-Golgi network) to the cell surface (indicated by the solid X). In addition, late after infec[r] ... See full document
8
Glycoprotein gIII of pseudorabies virus is multifunctional.
... functions as well, we determined whether replacement of the resident gIl gene of another virus strain (the Bartha strain, which is known to be released inefficiently from RK cells [3, 19[r] ... See full document
7
Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virus.
... mutant virus produced noninfectious progeny and was unable to spread from infected to uninfected cells by cell-cell fusion.. Thus, similar to gH of herpes simplex virus, gH of pseudorabi[r] ... See full document
5
Envelope glycoprotein gp50 of pseudorabies virus is essential for virus entry but is not required for viral spread in mice.
... Surprisingly, virus replication in the brain was limited in animals that were infected with the highly virulent strains NIA-3, R122[+], and M105, whereas extensive virus replication was [r] ... See full document
8
Role of glycoprotein gIII of pseudorabies virus in virulence.
... Deletion mutants of pseudorabies virus unable to express glycoprotein glll, gI, or gp63 or double and triple mutants defective in these glycoproteins were constructed, and their virulenc[r] ... See full document
6
Characterization and mapping of a nonessential pseudorabies virus glycoprotein.
... Antigenic variants of pseudorabies virus (PRV) containing mutations in a viral glycoprotein with a molecular weight of 82,000 (gIll) were isolated by selecting for resistance to a comple[r] ... See full document
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