[PDF] Top 20 Functionally Heterogeneous CD8+ T-Cell Memory Is Induced by Sendai Virus Infection of Mice
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Functionally Heterogeneous CD8+ T-Cell Memory Is Induced by Sendai Virus Infection of Mice
... peripheral virus challenge (4, 24). In contrast, resting memory cells are sufficient to protect from systemic viral chal- lenge but appear to lack the ability to recirculate into periph- eral ...eliminate ... See full document
9
Protracted Course of Lymphocytic Choriomeningitis Virus WE Infection in Early Life: Induction but Limited Expansion of CD8+ Effector T Cells and Absence of Memory CD8+ T Cells
... LCMV-specific CD8 ⫹ T cells elicited in 2-week-old mice fail to expand during the second week after infection? The expansion of a specific T-cell clone depends on the fre- quency ... See full document
13
Reduced Protection from Simian Immunodeficiency Virus SIVmac251 Infection Afforded by Memory CD8+ T Cells Induced by Vaccination during CD4+ T-Cell Deficiency
... adaptive T-cell responses (1). HIV is able to spread from cell to cell, integrate into the host chromosomes, and become ...⫹ T cells that populate the gastrointestinal tract and causes ... See full document
10
Vaccine-Induced, Pseudorabies Virus-Specific, Extrathymic CD4+CD8+ Memory T-Helper Cells in Swine
... vaccinia virus recombinants leads to a significant protection of pigs from PRV-infection (30, ...PRV infection induces a signif- icant amount of MHC class I-restricted and gC-specific cyto- toxic ... See full document
8
Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses
... in CD8 T-cell numbers flank- ing the peak of the LCMV-specific T-cell ...after infection on days 2 to 4 ...of CD8 T cells corresponds to the peak of the NK ... See full document
12
HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses
... immunodeficiency virus (HIV) infection is the major risk factor predisposing for Mycobacterium tuberculosis progression from latent tuberculosis in- fection (LTBI) to tuberculosis disease ...CD4 ... See full document
18
Persistent Enteric Murine Norovirus Infection Is Associated with Functionally Suboptimal Virus-Specific CD8 T Cell Responses
... NV infection has allowed the use of animal studies to dissect viral pathogenesis and immu- ...that infection is lethal in mice deficient in type I and II interferon (IFN) signaling or STAT1, while ... See full document
17
Virus-Specific CD4+ and CD8+ Cytotoxic T-Cell Responses and Long-Term T-Cell Memory in Individuals Vaccinated against Polio
... and CD8 T cells (17, 21, 23, 26). As normal mice lack the human poliovirus receptor (PVR) and are not, therefore, susceptible to poliovi- rus infection, the role of the PV-specific T ... See full document
8
Protective antifungal memory CD8+ T cells are maintained in the absence of CD4+ T cell help and cognate antigen in mice
... + T cells, are at increased risk for opportunistic fungal ...+ T cells play a dominant role in resistance to many pathogenic fungal infections, we have previously shown that vaccination can induce ... See full document
14
Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection
... Respiratory virus infections in the elderly result in increased rates of hospitalization and ...syncytial virus (RSV) is a leading cause of severe virus-induced respiratory disease in ... See full document
7
Sustained CD8+ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans
... especially CD8 ⫹ T-cell responses, has revealed an important role for such cells in a range of viral ...with mice, most work on acute infection has been focused on influenza and ... See full document
5
Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice
... in memory induction by different ImmuPatch ...influenza virus respiratory challenge ...systemic cell mediated immunity against liver-stage malaria as the protective mechanism ...systemic ... See full document
13
Neuropilin-1 Regulates the Secondary CD8 T Cell Response to Virus Infection
... in mice infected with the nonpersistent FS73 ...potent CD8 T cell response is induced after infection with either the FS73 or FS73R strain of MHV-68 ...latent infection in ... See full document
12
Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice
... viral infection or clearing a persistent viral infection with adoptive ...after infection with LCMV WE (37). After im- munization of B2/2 mice with LCMV Traub (45) or WE (37), initial ... See full document
9
Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8+ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection
... Virus-specific CD8 ⴙ T cells play a central role in the outcome of several viral infections, including hepatitis B virus (HBV) ...of virus-specific CD8 ⴙ T cells is the ... See full document
9
Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells
... reduced CD8 ⫹ T cell function, we treated mice with antibody against PD-L1 during infection to block the PD-1/ PD-1L ...in virus titers at day 10 in mice with high-path ... See full document
16
Epitope-Specific Regulatory CD4 T Cells Reduce Virus-Induced Illness while Preserving CD8 T-Cell Effector Function at the Site of Infection
... exhausted virus-specific CD8 T cells (3, 8) and could negatively regulate regulatory T cells by controlling STAT-5 phosphorylation ...CD4 T cells were reported to be defective in ... See full document
9
Characteristics and functions of Sendai virus-specific T-cell clones.
... The intravenous inoculation of T-cell clones, such as 2H3.B8, 2H3.E8, or 2H3.A5 106 cells per mouse, into mice which had received intranasally a lethal dose of SV 24 h earlier augmented [r] ... See full document
7
CD8+ T Cell Recognition of Cryptic Epitopes Is a Ubiquitous Feature of AIDS Virus Infection
... FIG. 2. Magnitude of cryptic epitope-specific T cell responses and locations of the epitopes. (A) An IFN- ␥ ELISPOT assay was used to measure the magnitude of cryptic epitope-specific responses. Each square ... See full document
7
Conditional CD8+ T Cell Escape during Acute Simian Immunodeficiency Virus Infection
... from CD8 ⫹ T cell responses is a hallmark of human immunodeficiency virus (HIV)/simian immunodeficiency vi- rus (SIV) infection (6, 16, ...detectable CD8 ⫹ T cell ... See full document
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