[PDF] Top 20 The functions of long noncoding RNAs in development and stem cells

... Constitutive LOF via genome engineering. Genome engineering can be performed using both traditional recombination-based techniques and TALEN/CRISPR technologies to target lncRNA genes. Small insertions or deletions ... See full document

... cancer development such as progression, invasion and metastasis ...MHCC97L cells, a positive correlation between the expression of lncRNA UCA1 and EMT markers such as Snail2 and Vimentin was identified, as ... See full document

... development, differentiation, activation and effector functions. As a relatively new subject, several lncRNAs, mechanisms of action and functions have not yet been elucidated. However, advances in ... See full document

... Long noncoding RNAs (lncRNAs) are operationally defined as RNA transcripts longer than 200 bp that do not appear to have coding potential ...lated functions as tumor suppressors or oncogenes ... See full document

... drug development. However, the delivery of lncRNAs into cancer cells directly is difficult by conventional RNA interference (RNAi) methods because of the large size and extensive secondary structures of ... See full document

... Abstract: Noncoding RNAs (ncRNAs) can be divided into microRNAs (miRNAs), long noncod- ing RNAs (lncRNAs), circular RNAs (circRNAs), pRNAs, and ... See full document

... of lncRNAs on signaling pathways and found that many ln- cRNAs control CRC properties by targeting different compo- nents thereof. Some components of signaling pathways have become attractive therapeutic targets because ... See full document

... the development of chronic diabetic ...as long ncRNAs (lncRNAs) that can regulate chromosomal function and gene expression ...controlling functions like protein synthesis, RNA maturation and ... See full document

... impeding development of (nc)RNA-based therapeutics, such as the inherent low stability of RNA molecules and tumor-specific delivery and ...tumor cells could be selectively targeted through the cell-surface ... See full document

... Recently, stem cell therapy, introducing mesenchy- mal stem cells (MSCs) or cytokines into target discs, appears as a promising strategy for the IDD treat- ...pulposus cells (NPCs), MSCs could ... See full document

... a long chain non-coding RNA with a transcript length of more than 8000 ...the development of malignant ...CNE-1 cells was significantly down-regulated by MALAT1 over- expression in CNE-1 cells ... See full document

... enhancer RNAs based on the phenomena that RNA polymerase II located to approximately 3000 activated enhancers and that RNAs could be produced from the extragenic enhancer regions of protein-coding genes ... See full document

... post-XCI cells, Xist is capable of trans-silencing autosomal regions where nucleation centers have been ectopically introduced, bypassing the developmental pro- gramming that would normally block these centers in ... See full document

... DLBCL cells, possibly through the PI3K/AKT/NF- κ B ...and functions as a tumor suppressor gene through the inhibition of cell growth via G0/G1 cell cycle arrest by inactivating the MAPK/ERK pathway in DLBCL ... See full document

... Neuroblastomas (NBs) are the third most common tumour affecting infants and young children, after leukemia and brain/central nervous system tumours. Moreover, around 7% of the total tumours observed in children are NBs. ... See full document

... Some nuclear DNA-encoded lncRNA could play a role in mitochondria-mediated apoptosis. ENS- MUST00000136025 is a nearby enhancer-like lncRNA of its neighboring BIM gene; BIM is a pro-apoptotic pro- tein and potentiates ... See full document

... and TUG1 is negatively correlated. Besides, the expression of MALAT1, HOTAIR, HNF1A-AS1, ANRIL, and PVT1 is associated positively with lymph node metastases, whereas the expression of SPRY4-IT1 and BANCR is negatively ... See full document

... This study addresses three distinct merits that are not evident in other studies. First, a panel of TSLNRs was identified via whole transcriptome sequencing and TCGA data analysis, thus providing a more efficient ... See full document

... Transcripts defined by Cuffmerge as unknown, that were also mulit-exonic and longer than 200 nucleotides were considered putative lncRNAs. These putative lncRNAs were then filtered for potential coding ability using ... See full document

... NPC cells through involvement in diverse cellular processes, including migration, invasion, and proliferation, and also indicates a poorer prognosis for DFS and ... See full document