[PDF] Top 20 ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
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ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
... That herpes simplex virus type 1 (HSV-1) induces apoptosis but then prevents its killing of infected cells is ...temperature-sensitive virus at its nonpermissive temper- ... See full document
12
Deletion of the Herpes Simplex Virus VP22-Encoding Gene (UL49) Alters the Expression, Localization, and Virion Incorporation of ICP0
... the herpes simplex virus tegument protein VP22 is not yet ...a virus in which the entire VP22 open reading frame has been ...for virus growth but that virus lacking VP22 ( ⌬ 22) ... See full document
11
Origin of Expression of the Herpes Simplex Virus Type 1 Protein US1.5
... 1.5 expression is conserved among many strains of HSV and is not an artifact of genome rearrangement specific to strain ...mutant virus d22:GFP, in which the ICP22 gene is re- placed by a GFP ...and ... See full document
12
Impact of the Interaction between Herpes Simplex Virus Type 1 Regulatory Protein ICP0 and Ubiquitin-Specific Protease USP7 on Activation of Adeno-Associated Virus Type 2 rep Gene Expression
... rep gene expression by ICP0 in transfected and infected ...selected ICP0 mutants to activate rep gene expression in trans- fected cells and to activate HSV-1 early ... See full document
5
Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner
... viral gene expression by ICP0 is closely associated with its capacity to disrupt nuclear domain 10 (ND10) structures (also known as protein promyelocytic leukemia [PML] nuclear bodies) (37, ... See full document
10
Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100
... stimulate ICP0-null mutant HSV-1 plaque formation in either human fibroblasts or HepaRG cells, although it did increase plaque numbers in Vero cells ...increase ICP0-null mutant HSV-1 repli- ... See full document
12
Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells.
... To examine the role of ICPO in the regulation of viral gene expression during productive infection, we characterized the wild-type virus, an ICPO null mutant 7134, and several ICPO nonse[r] ... See full document
12
Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice
... adult ICP0--galactosidase transgenic mice (Tg3180) contained moderate numbers of -galactosidase-positive neurons ...transgene: ICP0--galactosidase (Tg6825), ICP27--galactosidase (Tg3058 and Tg6818), and ... See full document
11
Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication
... resistance gene (36), to produce ...FIG 1 Schematic of the genome structure of wild-type HSV-1(F) and the recombinant viruses used in this ...Line 1, wild-type HSV-1(F) ... See full document
14
PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0
... leukemia virus gag/pol) together with pVSV-G and a pSIREN-RetroQ ...stomatitis virus coat protein and including the shRNA transcription unit and a puromycin resistance ... See full document
11
Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro
... enous gene encoding the cell surface marker CD44 served as a positive control, since CD44 is known to be regulated by BRM and Brg-1 in these cells (64, ...mRNA expression was induced in both SW13 and ... See full document
14
Activities of ICP0 Involved in the Reversal of Silencing of Quiescent Herpes Simplex Virus 1
... latent herpes simplex virus 1 ...of ICP0 contribute its activity, the most prominent of which appears to be the RING finger, which confers E3 ubiquitin ligase ...of ICP0 has also ... See full document
10
Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0
... lower expression of the HA-ICP0 bait, as few peptides of these interactors were observed in the HA-RFm ...for ICP0 in this ...of ICP0’s known substrate USP7, we did not observe an increase in ... See full document
10
Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon
... of ICP0 coding sequences, while n212 is truncated by an amber codon following residue ...the ICP0 gene. ICP0 mutants display impaired expression of IE, early, and late genes during ... See full document
5
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... Herpes Simplex Virus (HSV) type I causes cold sores but is also associated with severe outcomes such as encephalitis and ...latent virus persists in neurons, from which it can ... See full document
353
Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression.
... Fifteen to fifty percent of wild-type levels of viral DNA are synthesized at the nonpermissive temperature in ts48- and ts303-infected cells, indicating that immediate-early and early ge[r] ... See full document
10
Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells.
... antiapoptosis gene, we examined the effect of phospho- noacetic acid (PAA) on the expression of this ...of expression (Fig. 3A) as well as the fact that expression was not affected by the ... See full document
5
Structure and expression of the herpes simplex virus type 2 glycoprotein gB gene.
... Anatomy of the herpes simplex virus type 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants.. [r] ... See full document
10
Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.
... Regulation of the herpes simplex virus type 1 late gamma2 glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation [r] ... See full document
7
Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture
... neurons. ICP0 RNA could be detected by in situ hybridization in a small number of infected neurons ...(Fig. 1, inset) despite the absence of ICP0 protein ...GFP expression, than expressed ... See full document
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